File:GKRP Chain A, F6P binding site.png
Jump to navigation
Jump to search
Size of this preview: 646 × 600 pixels. Other resolutions: 259 × 240 pixels | 517 × 480 pixels | 948 × 880 pixels.
Original file (948 × 880 pixels, file size: 196 KB, MIME type: image/png)
Summary
| Description |
English: Fructose-6-phosphate (F6P) is an allosteric activator of GKRP, meaning it binds to GKRP at a site distinct from its active site. F6P induces a conformational change in GKRP which promotes the formation of the glucokinase-GKRP complex, thereby increasing the ability of GKRP to inhibit glucokinase. Residues S110, S179, K514, and T109 within the binding site for F6P were determined to be critical to the ability of F6P to induce this conformational change in GKRP. Mutations of these residues resulted in proteins that were 5-fold (S110), 10-fold (T109), and 50-fold (S179 and K514) less effective inhibitors glucokinase and had significantly reduced affinity for F6P. |
| Date | |
| Source | Own work |
| Author | Eperda |
Licensing
I, the copyright holder of this work, hereby publish it under the following license:
 
|
This file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication. |
| The person who associated a work with this deed has dedicated the work to the public domain by waiving all of their rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law. You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission.
|
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 04:15, 8 February 2025 | | 948 × 880 (196 KB) | wikimediacommons>Eperda | Uploaded own work with UploadWizard |
File usage
The following page uses this file:
