File:Steroidogenesis.png

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

Original file (2,075 × 1,842 pixels, file size: 940 KB, MIME type: image/png)

This file is from Wikimedia Commons and may be used by other projects. The description on its file description page there is shown below.

Summary

Description
English: *Enzymes, their cellular location, substrates and products in human steroidogenesis.
  • Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids.
  • White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see structural formula.
  • Arrows are shown as unidirectional to indicate the usual net directions, but technically all biochemical reactions are considered bidirectional.

HSD: Hydroxysteroid dehydrogenase

References:

  • Boron WF, Boulpaep EL (2003) Medical Physiology: A Cellular And Molecular Approach, Elsevier/Saunders, pp. page 1,300 ISBN: 1-4160-2328-3.
  • For the absence of conversion of corticosterone to cortisol: Steroid hormone biosynthesis Reference pathway (KO). KEGG: Kyoto Encyclopedia of Genes and Genomes. Kyoto University Bioinformatics Center. (1 November 2013).
There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase.

Further reading:

  • Hanukoglu I (1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". The Journal of Steroid Biochemistry and Molecular Biology 43 (8): 779–804. DOI:10.1016/0960-0760(92)90307-5. PMID 22217824.
  • Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocrine Reviews 25 (6): 947–70. DOI:10.1210/er.2003-0030. PMID 15583024.

See also:

Polski: Enzymy biorące udział w steroidogenezie.

Uwagi: W miejscu gdzie stereochemia nie jest wyświetlana, jest taka sama jak dla Cholesterol lub w pokazanej powyżej grupie.

HSD: Dehydrogenaza hydroksysteroidu
Русский: Ферменты, участвующие в стероидогенезе человека, с указанием субстратов и продуктов, а также локализации их активности. Происходящие изменения в структуре молекул отмечены белыми кружочками. По сборнику "Медицинская физиология" (Walter F. Boron, Emile L. Boulpaep, 2003 год).
日本語: この図はヒトのステロイドホルモン生成における酵素と酵素が存在する細胞器官、基質ならびに生成物の全体図である。またこの図は（コレステロールから）プロゲステロン、鉱質コルチコイド、糖質コルチコイド、そしてアンドロゲンおよびエストロゲンに至る主要なステロイドを記述している。

図に示すとおりそれぞれ（生合成の過程で）オーバーラップするものである。 図中、白い円で囲んだところは基質と比較した分子構造の変化した箇所を示す。

なお、HSD は、ヒドロキシステロイドデヒドロゲナーゼを表す。
Date
Source Häggström M, Richfield D (2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine 1 (1). DOI:10.15347/wjm/2014.005. ISSN 20024436.
Author

David Richfield (Slashme) and Mikael Häggström. Derived from previous version by Hoffmeier and Settersr.

In external use, this diagram may be cited as:

Other versions

edit

Original. See also Evolution.
Raster (.png) version is available

Translations

  • 中文
    中文
  • 國語
    國語
  • Русский
    Русский
  • Galego
    Galego
  • العربية
    العربية
  • polski
    polski
  • German
    German
  • 日本語
    日本語
PNG development
InfoField
 This structural formula was created with Inkscape.
 The chemistry symbols of this structural formula are drawn using the path text method.

Evolution

A short flashback of some milestones the evolution of the picture, demonstrating the power of free licensing where anybody can contribute to making things better.

1. (March 2007) Previous image by Stannered.
4. (August 2008) Vector (.svg) version by Slashme.
2. (July 2007) Molecular structures added by Hoffmeier and Settersr.
5. (March 2009) Expansion, grouping, addition of enzyme localization, numbering of cholesterol and coloring by Mikael Häggström.
3. (November 2007) Organization and addition of enzymes by Mikael Häggström.
File:Steroidogenesis.svg is a vector version of this file. It should be used in place of this PNG file when not inferior.
File:Steroidogenesis.png → File:Steroidogenesis.svg
For more information, see Help:SVG.
In other languages
Alemannisch ∙ العربية ∙ беларуская (тарашкевіца) ∙ български ∙ বাংলা ∙ català ∙ нохчийн ∙ čeština ∙ dansk ∙ Deutsch ∙ Ελληνικά ∙ English ∙ British English ∙ Esperanto ∙ español ∙ eesti ∙ euskara ∙ فارسی ∙ suomi ∙ français ∙ Frysk ∙ galego ∙ Alemannisch ∙ עברית ∙ हिन्दी ∙ hrvatski ∙ magyar ∙ հայերեն ∙ Bahasa Indonesia ∙ Ido ∙ italiano ∙ 日本語 ∙ ქართული ∙ 한국어 ∙ lietuvių ∙ македонски ∙ മലയാളം ∙ Bahasa Melayu ∙ မြန်မာဘာသာ ∙ norsk bokmål ∙ Plattdüütsch ∙ Nederlands ∙ norsk nynorsk ∙ norsk ∙ occitan ∙ polski ∙ prūsiskan ∙ português ∙ português do Brasil ∙ română ∙ русский ∙ sicilianu ∙ Scots ∙ slovenčina ∙ slovenščina ∙ српски / srpski ∙ svenska ∙ தமிழ் ∙ ไทย ∙ Türkçe ∙ татарча / tatarça ∙ українська ∙ vèneto ∙ Tiếng Việt ∙ 中文 ∙ 中文（中国大陆） ∙ 中文（简体） ∙ 中文（繁體） ∙ 中文（马来西亚） ∙ 中文（新加坡） ∙ 中文（臺灣） ∙ +/−
New SVG image

Licensing

Creative Commons CC-Zero This file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication.
The person who associated a work with this deed has dedicated the work to the public domain by waiving all of their rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law. You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission.

Captions

Add a one-line explanation of what this file represents

Items portrayed in this file

depicts

inception

28 March 2009

media type

image/png

checksum

f4cf1c2c2e89ee648f60cbf291af32ebf61934da

determination method or standard: SHA-1

data size

962,257 byte

height

1,842 pixel

width

2,075 pixel

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current15:22, 13 March 2013Thumbnail for version as of 15:22, 13 March 20132,075 × 1,842 (940 KB)wikimediacommons>SlashmeRemoved link from corticosterone to cortisol via CYP17A1, which is incorrect (according to http://www.genome.jp/kegg-bin/show_pathway?ko00140+C02140 )

The following page uses this file:

Retrieved from "https://wiki.sarg.dev/index.php/File:Steroidogenesis.png"