File:Structure and function of the nuclear lamina.jpg
Jump to navigation
Jump to search
Size of this preview: 800 × 395 pixels. Other resolutions: 320 × 158 pixels | 640 × 316 pixels | 1,200 × 593 pixels.
Original file (1,200 × 593 pixels, file size: 133 KB, MIME type: image/jpeg)
| Description |
English: Structure and function of the nuclear lamina. The nuclear lamina lies on the inner surface of the inner nuclear membrane (INM), where it serves to maintain nuclear stability, organize chromatin and bind nuclear pore complexes (NPCs) and a steadily growing list of nuclear envelope proteins (purple) and transcription factors (pink). Nuclear envelope proteins that are bound to the lamina include nesprin, emerin, lamina-associated proteins 1 and 2 (LAP1 and LAP2), the lamin B receptor (LBR) and MAN1. Transcription factors that bind to the lamina include the retinoblastoma transcriptional regulator (RB), germ cell-less (GCL), sterol response element binding protein (SREBP1), FOS and MOK2. Barrier to autointegration factor (BAF) is a chromatin-associated protein that also binds to the nuclear lamina and several of the aforementioned nuclear envelope proteins. Heterochromatin protein 1 (HP1) binds both chromatin and the LBR. ONM, outer nuclear membrane [9]. Coutinho et al. Immunity & Ageing 2009 6:4 doi:10.1186/1742-4933-6-4 Русский: "Структура и функции ядерной ламины". Ядерная ламина прилегает к внутренней поверхности внутренней ядерной мембраны (INM) и помогает поддерживать ядро в стабильном состоянии, участвует в организации хроматина, связывает ядерные поры. Также ядерная ламина взаимодействует с белками ядерной оболочки, число которых в последнее время постоянно растёт благодаря новым открытиям. Белки отмечены пурпурным цветом. Среди белков оболочки, связывающихся с мембраной - такие белки, как несприн, эмерин, LAP1, LAP2, рецептор ламина B и MAN1. Также к ламине присоединяются факторы транскрипции, такие как retinoblastoma transcriptional regulator (RB), germ cell-less (GCL), sterol response element binding protein (SREBP1), FOS and MOK2. |
| Date | |
| Source | Molecular ageing in progeroid syndromes: Hutchinson-Gilford progeria syndrome as a model (Review) |
| Author | Henrique Douglas M Coutinho , Vivyanne S Falcão-Silva, Gregório Fernandes Gonçalves and Raphael Batista da Nóbrega |
| Permission (Reusing this file) |
© 2009 Coutinho et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
This file is licensed under the Creative Commons Attribution 2.0 Generic license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 10:52, 3 January 2010 | | 1,200 × 593 (133 KB) | wikimediacommons>CopperKettle | {{Information |Description={{en|1=Structure and function of the nuclear lamina. The nuclear lamina lies on the inner surface of the inner nuclear membrane (INM), where it serves to maintain nuclear stability, organize chromatin and bind nuclear pore compl |
File usage
The following page uses this file:
