Jamaica ginger

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Bottles of "Jamaica ginger," also called "Jake."
Tri-ortho cresyl phosphate(TOCP), also called tricresyl phosphate, was the neurotoxin responsible for the paralysis associated with "Jake Walk."
Sampling "Ginger Jake", April 2, 1932

Jamaica ginger extract, known in the United States by the slang name Jake, was a late 19th-century patent medicine that provided a convenient way to obtain alcohol during the era of Prohibition, since it contained approximately 70% to 80% ethanol by weight.<ref name=":0">Template:Cite journal</ref><ref name=":1">Template:Cite journal</ref> In the 1930s, a large number of users of Jamaica ginger were afflicted with a paralysis of the hands and feet that quickly became known as Jamaica ginger paralysis or jake paralysis.<ref name=":0" /><ref name=":1" />

Composition

While Jamaica ginger was essentially an infusion of ginger, the US government required solids to be added with the intention of making it less palatable as a way to obtain alcohol legally. The solids expected to be added were particles of ginger root, which made the "medicine" unpalatable. Manufacturers sought solids which impaired the taste less; tricresyl phosphate was used, which the producers later found to be a potent neurotoxin; adulterated Jake is estimated to have caused 30,000 to 50,000 people to lose function in their limbs. Trust in Jamaica Ginger was lost, and its production was discontinued.<ref>Template:Cite web</ref>

Early use and Prohibition

Since the 1860s, Jamaica ginger had been widely sold at drug stores and roadside stands in Template:Convert bottles.<ref name=":0" /><ref name=":1" /><ref name=":3" /> In small doses, mixed with water, it was used as a remedy for headaches, upper respiratory infections, menstrual disorders, and intestinal gas.<ref name=":0" /><ref name=":1" /> Despite its strong ginger flavour, it was popular as an alcoholic beverage in dry counties in the United States, where it was a convenient and legal method of obtaining alcohol.<ref name=":0" /> It was often mixed with a soft drink to improve the taste.<ref name=":0" />

When Prohibition was enacted in 1920, sale of alcohol became illegal nationwide, prompting consumers to search for substitutes.<ref>Template:Cite web</ref> Patent medicines with a high alcohol percentage, such as Jamaica ginger, became obvious choices, as they were legal and available over the counter without prescriptions. By 1921, the United States government made the original formulation of Jamaica ginger prescription-only.<ref name=":2">Template:Cite book</ref> Only a fluid extract version defined in the United States Pharmacopeia, with a high content of bitter-tasting ginger oleoresin, remained available in stores.<ref name=":0" /><ref name=":2" /> Because of the taste, it was classified as nonpotable, and was therefore legal to sell despite the alcohol content.<ref name=":0" />

United States Department of Agriculture agents audited Jamaica ginger manufacturers by boiling samples and weighing the resulting solids, to make sure their products contained sufficiently high quantities of the bitter-tasting ginger.<ref name=":3" /> To make their products more palatable, manufacturers of Jamaica ginger began to illegally replace the ginger oleoresin with cheaper ingredients like molasses, glycerin, and castor oil, cutting costs and significantly diminishing the unpleasant ginger flavor.<ref name=":0" /><ref name=":3">Template:Cite book</ref>

Victims

Organophosphate-induced delayed neuropathy

When the price of castor oil increased in the latter portion of the 1920s, Harry Gross, president of Hub Products Corporation, sought an alternative additive for his Jamaica ginger formula. He discarded ethylene glycol and diethylene glycol as being too volatile, eventually selecting a mixture containing triorthocresyl phosphate (TOCP), a plasticizer used in lacquers and paint finishing. Gross was advised by the manufacturer of the mixture, Celluloid Corporation, that it was non-toxic.<ref name=":3" />Template:Sfn

TOCP was originally thought to be non-toxic; however, it was later determined to be a neurotoxin that causes axonal damage to the nerve cells in the nervous system of human beings, especially those located in the spinal cord. The resulting type of paralysis is now referred to as organophosphate-induced delayed neuropathy, or OPIDN.Template:Sfn

In 1930, large numbers of Jake users began to find they were unable to use their hands and feet.<ref>Template:Cite news</ref> Some victims could walk, but they had no control over the muscles which would normally have enabled them to point their toes upward. Therefore, they would raise their feet high with the toes flopping downward, which would touch the pavement first followed by their heels. The toe first, heel second pattern made a distinctive "tap-click, tap-click" sound as they walked. This very peculiar gait became known as the jake walk and the jake dance and those afflicted were said<ref>Template:Citation</ref> to have jake leg, jake foot, or jake paralysis. Additionally, the calves of the legs would soften and hang down and the muscles between the thumbs and fingers would atrophy.

Within a few months, the TOCP-adulterated Jake was identified as the cause of the paralysis,<ref name=msu>Template:Cite web</ref> and the contaminated Jake was recovered. But by that time, it was too late for many victims. Some did recover full, or partial, use of their limbs. But for most, the loss was permanent. The total number of victims was never accurately determined, but is frequently quoted as between 30,000 and 50,000. Many victims were immigrants to the United States, and most were poor, with little political or social influence. The victims received very little assistance.Template:Citation needed Harry Gross and his part-owner of Boston-Hub Products, Max Reisman, were ultimately fined $1,000 each and given a two-year suspended jail sentence.<ref name=msu/>

Several blues songs on the subject were recorded in the early 1930s, such as "Jake Walk Papa" by Asa Martin, and "Jake Liquor Blues" by Ishman Bracey.Template:Sfn

Although this incident became well known, later cases of organophosphate poisoning occurred in Germany, Spain, Italy, and, on a large scale, in Morocco in 1959, where cooking oil adulterated with jet engine lubricant from an American airbase led to paralysis in approximately 10,000 victims, and caused an international incident.<ref>Template:Cite journal</ref>

Cultural references

Books

  • In Sara Gruen's 2006 novel Water for Elephants jake paralysis afflicts one character, Camel, after drinking contaminated Jamaica Ginger.
  • In the novel The Black Dahlia, the protagonist reveals early on that his mother went blind and fell to her death after drinking jake, leading to his resentment of his father for purchasing it.
  • In his autobiography On the Move: A Life, Oliver Sacks describes research that he conducted to develop an animal model of jake paralysis. He was able to duplicate the toxic effects of TOCP on myelinated neurons in earthworms and chickens.
  • In Jamie Ford's novel Hotel on the Corner of Bitter and Sweet the two young characters Henry and Keiko are given a prescription for Jamaican Ginger in the 1942 portion of the story. They go to the pharmacy, pick up the bottles, and return to the Black Elks club. Due to war rationing and systemic oppression at the time, the black jazz club is not allowed to have a liquor license, so the proprietor uses Jamaican Ginger to make bathtub gin.

Music

Songs were recorded at the time about "jake" and its effects; in a variety of musical styles, including blues and country. Several have been included on the compilation albums Jake Walk Blues (1977, 14 songs)<ref>Template:Discogs release</ref> and Jake Leg Blues (1994, 16 songs)<ref>Template:Discogs release</ref><ref>Template:AllMusic</ref> There is a marked but unsurprising duplication of songs between those albums. In some cases, different artists used the same title for different songs. The songs on one or both of those albums are, in alphabetic order by title:

Other musical references include:

Film and television

  • Jamaica ginger ("Ginger Jake") is a plot element in two episodes of The Untouchables, an American TV series.<ref name="TV dot com">Staff Writer, "The Jamaica Ginger Story", TV.com, Date Unknown</ref> "The Jamaica Ginger Story" aired in season 2 on February 2, 1961.<ref>Template:Citation</ref> "Jake Dance" aired on January 22, 1963.<ref>Template:Citation</ref>
  • "Ginger Jake" also makes an appearance in the movie Quid Pro Quo, where "wannabes" (people who would like to be disabled) are helped by Ginger Jake to become disabled.

References

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Further reading

  • Baum, Dan, "Jake Leg", The New Yorker September 15, 2003, p. 50-57. (PDF)
  • Blum, Deborah. The Poisoner's Handbook: Murder and the Birth of Forensic Medicine in Jazz Age New York (Penguin Press, February 18, 2010)
  • Burns, Eric. The Spirits of America: A Social History of Alcohol (Philadelphia: Temple University Press, 2003) pp. 221–223
  • Kidd, J. G, and Langworthy, O. R. Jake paralysis. Paralysis following the ingestion of Jamaica ginger extract adulterated with triortho-cresyl phosphate. Bulletin of the Johns Hopkins Hospital, 1933, 52, 39.
  • Gussow, Leon MD. The Jake Walk and Limber Trouble: A Toxicology Epidemic. Emergency Medicine News"". 26(10):48, October 2004. [1]
  • Morgan, John P. and Tulloss, Thomas C. The Jake Walk Blues: A toxicological tragedy mirrored in popular music. JEMF (John Edward s Memorial Foundation) Quarterly, 1977, 122-126.
  • Template:Cite book
  • U.S. Congress, Office of Technology Assessment, Neurotoxicity: Identifying and Controlling Poisons of the Nervous System, OTA-BA-436 (Washington, DC: U.S. Government Printing Office, April 1990).
  • Kearney, Paul W. Our Food and Drug G-Men The Progressive July 10, 1944
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