James B. Sumner

Template:Short description Template:More citations needed Template:Infobox scientist James Batcheller Sumner (November 19, 1887 – August 12, 1955) was an American biochemist. He discovered that enzymes can be crystallized, for which he shared the Nobel Prize in Chemistry in 1946 with John Howard Northrop and Wendell Meredith Stanley.<ref>Template:Cite web</ref> He was also the first to prove that enzymes are proteins.

Biography

Sumner was born on November 19, 1887, in Canton, Massachusetts.<ref name=Carey>Template:Cite book</ref>

While hunting at age 17, Sumner was accidentally shot by a companion and as a result his left arm had to be amputated just below the elbow. He had been left-handed before the accident, after which he had to learn to do things with his right hand.<ref name=Nobelbio/>

Sumner graduated from Harvard University with a bachelor's degree in 1910<ref name=Carey /> where he was acquainted with prominent chemists Roger Adams, Farrington Daniels, Frank C. Whitmore, James Bryant Conant and Charles Loring Jackson.Template:Citation needed After a short period of working in the cotton knitting factory owned by his uncle, he accepted a teaching position at Mount Allison University in Sackville, New Brunswick, Canada. For the year 1911-12 he worked as a teaching assistantship in chemistry at Worcester Polytechnic Institute.<ref name="Nobelbio"/>

In 1912, he went to study biochemistry in Harvard Medical School and obtained his Ph.D. degree in 1914 with Otto Folin. He then worked as assistant professor of biochemistry at Cornell Medical School in Ithaca, NY.<ref name="Nobelbio">Template:Cite web</ref>

Sumner married Cid Ricketts (born Bertha Louise Ricketts in Brookhaven, Mississippi) when she attended medical school at Cornell. They married on July 10, 1915, and had four children.<ref>"Cid Ricketts Sumner" Template:Webarchive, Mississippi Artists and Musicians website. Retrieved July 22, 2012.</ref> They were divorced in 1930, but she kept her married name. Cid Ricketts Sumner went on to become an author, writing books that included Tammy Tell Me True, which was made into the movie Tammy and the Bachelor, and Quality, which became the movie Pinky. Cid Ricketts Sumner was murdered by their grandson, John R. Cutler, in 1970.

In 1931 Sumner married Agnes Lundkvist. In 1943 they divorced; later that year he married Mary Beyer, with whom he had two children.<ref name=Carey />

Research

It was in 1917 at Cornell where Sumner began his research into isolating enzymes in pure form; a feat which had never been achieved before.<ref name=Carey /> The enzyme he worked with was urease, which he isolated from jack beans. Sumner's work was unsuccessful for many years and many of his colleagues were doubtful, believing that what he was trying to achieve was impossible, but in 1926 he demonstrated that urease could be isolated and crystallized. He accomplished this by mixing purified urease with acetone and then chilling it; the chilled solution produced crystallized urease.<ref name=Carey /> He was also able to show by chemical tests that his pure urease was a protein.<ref>The chemical nature of enzymes (Nobel lecture) See p.117: "It gave tests for protein and possessed a very high urease activity."</ref> This was the first experimental proof that an enzyme is a protein, a controversial question at the time.

His successful research brought him to full professorship at Cornell in 1929. From 1924 on his laboratory was located on the second floor of the new dairy science building, Stocking Hall (today home to Food Science), at Cornell where he did his Nobel Prize–winning research. In 1937 he succeeded in isolating and crystallizing a second enzyme, catalase. By this time, John Howard Northrop of the Rockefeller Institute had obtained other crystalline enzymes by similar methods, starting with pepsin in 1929. It had become clear that Sumner had devised a general crystallization method for enzymes, and also that all enzymes are proteins.

Honors and awards

In 1937, he was given a Guggenheim Fellowship and he spent five months in Sweden working with Professor Theodor Svedberg. Also that year, he was awarded the Scheele Award in Stockholm.

Both Sumner and Northrop, along with Wendell M Stanley, shared the Nobel Prize in 1946 for crystallization of enzymes.<ref name=Carey /> In 1947 Sumner became the director of Cornell's enzyme chemistry laboratory.<ref name=Carey /> Sumner was elected to the National Academy of Sciences in 1948.<ref name=Carey /> In 1949, he was elected a Fellow of the American Academy of Arts and Sciences.<ref name=AAAS>Template:Cite web</ref>

Death

Sumner died at age 67 of cancer in Buffalo, New York on August 12, 1955.

Further reading

• Template:Nobelprize including the Nobel Lecture, December 12, 1946 The Chemical Nature of Enzymes
• Template:Cite journal
• Template:Cite journal

External links

• Sumner's Nobel Lecture The Chemical Nature of Enzymes
• Sumner's Speech at the Nobel banquet