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Thomas Gallaudet met Alice Cogswell on May 25, 1814, the nine-year-old deaf daughter of a neighbor, Dr. Mason Cogswell.Template:Sfn Gallaudet had returned to his parents' home in Hartford to recuperate from his seminary studies. On that day, as he observed Alice playing apart from other children, he wanted to teach her. Gallaudet started to teach Alice what different objects were called by writing their names and drawing pictures of them with a stick in the dirt.
Dr. Cogswell was impressed and invited Gallaudet to continue teaching Alice through the summer. While many of his friends became pastors or found mission fields overseas, Gallaudet found his mission field at home.Template:Efn
In 1815 Dr. Cogswell, with several businessmen and clergy, asked Gallaudet to travel to Europe to study methods for teaching deaf students, especially those established by the Braidwood family in Scotland. Gallaudet found Robert Kinniburgh (the head of Braidwood Academy at the time) unwilling to share knowledge of their oral communication method and himself financially limited.<ref>Template:Cite book</ref> At the same time, he also was not satisfied that the oral method produced desirable results.
While still in the United Kingdom, he met Abbé Sicard, head of the Institution Nationale des Sourds-Muets à Paris, and two of its deaf faculty members, Laurent Clerc and Jean Massieu. Sicard invited Gallaudet to Paris to study the school's method of teaching the deaf using manual communication. Impressed with the manual method, Gallaudet studied teaching methodology under Sicard, learning sign language from Massieu and Clerc, who were both highly educated graduates of the school.
Having persuaded Clerc to accompany him, Gallaudet sailed back to America. The two men, with the help of Dr. Cogswell, toured New England and successfully raised private and public funds to fund a school for deaf students in Hartford, which later became known as the American School for the Deaf (ASD), in 1817. Young Alice was one of the first seven students at ASD.
After resigning directorship of his school for the deaf in 1830, Gallaudet wrote educational and religious texts, became the chaplain to the Connecticut Retreat for the Insane in 1838, and taught in Hartford; the young Frederic Edwin Church was a notable pupil during this period.<ref>Template:Cite book</ref>
In 1864, his youngest child Edward Miner Gallaudet (1837–1917) founded the first college for the deaf, which, in 1986, became Gallaudet University. He was president for 46 years. The university also offers education for those in elementary, middle, and high school. The elementary school on the Gallaudet University Campus is named the Kendall Demonstration Elementary School (KDES); the middle and high school is the Model Secondary School for the Deaf (MSSD).
Gallaudet had another son, Thomas Gallaudet, who became an Episcopal priest and also worked for the deaf.
Thomas Hopkins Gallaudet was the eldest of 13 children. His younger siblings were: Edgar (1789–90), Charles (1792–1830), (unnamed twins, 1793), Catherine (1793–1856), James (1796–1878), William Edgar (1797–1821), Ann Watts (1800–1850), Jane (1801–1835), Theodore (1805–1885), Edward (1808–1847), and Wallace (1811–1816).Template:Sfn William Edgar Gallaudet graduated from Yale with a B.A. in 1815.
Gallaudet, Edward Miner. Letter to J.H. McFarlane (undated). Published in Deaf-Mutes' Journal, vol. 51, no. 46 (November 16, 1922), p. 2.
Gallaudet, Thomas Hopkins. 1844. Letter to Horace Mann. Quoted in Heman Humphrey. 1857. The Life and Labors of the Rev. T.H. Gallaudet, LL.D., New York: Robert Carter & Brothers, pp. 209–212.