View source for Arteriovenous malformation

{{Short description|Abnormal connection between arteries and veins, bypassing the capillaries}}
{{About|the anomaly generally|its occurrence in the brain|Cerebral arteriovenous malformation}}
{{Use mdy dates|date=March 2023}}
{{Infobox medical condition
| name            = Arteriovenous malformation
| synonyms        = AVM
| image           = Arteriovenous malformation - brain - low mag.jpg
| caption         = [[Micrograph]] of an arteriovenous malformation in the brain. [[HPS stain]].
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| field           = [[Neurosurgery]]
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| diagnosis       = CT, MRI, MRA
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An '''arteriovenous malformation''' ('''AVM''') is an abnormal connection between [[arteries]] and [[vein]]s, bypassing the [[capillary]] system. Usually [[congenital]], this [[vascular anomaly]] is widely known because of its occurrence in the [[central nervous system]] (usually as a [[cerebral AVM]]), but can appear anywhere in the body. The symptoms of AVMs can range from none at all to intense pain or bleeding, and they can lead to other serious medical problems.<ref name="NINDS" />

== Signs and symptoms ==
Symptoms of AVMs vary according to their location. Most [[neurological]] AVMs produce few to no symptoms. Often the malformation is discovered as part of an [[autopsy]] or during treatment of an unrelated disorder (an "[[incidental finding]]"); in rare cases, its expansion or a micro-bleed from an AVM in the brain can cause [[epilepsy]], [[neurological deficit]], or pain.<ref>{{cite web|title=Arteriovenous Malformations|url=https://www.hopkinsmedicine.org/health/conditions-and-diseases/arteriovenous-malformations|website=[[Johns Hopkins Medicine]]|access-date=26 October 2022}}</ref>

The most general symptoms of a [[cerebral AVM]] include [[headache]]s and epileptic [[seizure]]s, with more specific symptoms that normally depend on its location and the individual, including:<ref name=NINDS>{{NINDS|Arteriovenous-Malformation|Arteriovenous Malformation Information Page}}<!--An older form of this page can be found at https://web.archive.org/web/20161205043316/http://www.ninds.nih.gov:80/disorders/avms/detail_avms.htm --></ref>
* Difficulties with movement coordination, including [[muscle weakness]] and even [[paralysis]];
* [[Vertigo]] (dizziness);
* Difficulties of speech ([[dysarthria]]) and communication, as found with [[aphasia]];
* Difficulties with everyday activities, as found with [[apraxia]];
* Abnormal sensations (numbness, tingling, or spontaneous pain);
* Memory and thought-related problems, such as [[confusion]], [[dementia]], or [[hallucination]]s.

Cerebral AVMs may present themselves in a number of different ways:{{citation needed|date=March 2023}}
* [[Bleeding]] (45% of cases)
* "[[parkinsonism]]" 4 symptoms in [[Parkinson's disease]].
* Acute onset of severe headache. May be described as the worst headache of the patient's life. Depending on the location of bleeding, may be associated with new fixed neurologic deficit. In unruptured brain AVMs, the risk of spontaneous bleeding may be as low as 1% per year. After a first rupture, the annual bleeding risk may increase to more than 5%.<ref>{{cite journal |last1=Stapf |first1=C. |last2=Mast |first2=H. |last3=Sciacca |first3=R. R. |last4=Choi |first4=J. H. |last5=Khaw |first5=A. V. |author6-link=E. Sander Connolly|last6=Connolly |first6=E. S. |last7=Pile-Spellman |first7=J. |last8=Mohr |first8=J. P. |title=Predictors of hemorrhage in patients with untreated brain arteriovenous malformation |journal=Neurology |volume=66 |issue=9 |pages=1350–5 |year=2006 |pmid=16682666 |doi=10.1212/01.wnl.0000210524.68507.87 |s2cid=22004276 }}</ref>
* Seizure or brain seizure (46%). Depending on the place of the AVM, it can contribute to [[loss of vision]].
* Headache (34%)
* Progressive neurologic deficit (21%)
** May be caused by mass effect or venous dilations. Presence and nature of the deficit depends on location of the lesion and the draining veins.<ref>{{cite journal |last1=Choi |first1=J.H. |last2=Mast |first2=H. |last3=Hartmann |first3=A. |last4=Marshall |first4=R.S. |last5=Pile-Spellman |first5=J. |last6=Mohr |first6=J.P. |last7=Stapf |first7=C. |title=Clinical and morphological determinants of focal neurological deficits in patients with unruptured brain arteriovenous malformation |journal=Journal of the Neurological Sciences |volume=287 |issue=1–2 |pages=126–30 |year=2009 |pmid=19729171 |pmc=2783734 |doi=10.1016/j.jns.2009.08.011 }}</ref>
* Pediatric patients
** [[Heart failure]]
** [[Macrocephaly]]
** Prominent scalp veins

=== Pulmonary arteriovenous malformations ===

Pulmonary arteriovenous malformations are abnormal communications between the veins and arteries of the [[pulmonary circulation]], leading to a right-to-left blood shunt.<ref name="Reichert">{{cite journal |last1=Reichert |first1=M |last2=Kerber |first2=S |last3=Alkoudmani |first3=I |last4=Bodner |first4=J |title=Management of a solitary pulmonary arteriovenous malformation by video-assisted thoracoscopic surgery and anatomic lingula resection: video and review. |journal=Surgical Endoscopy |date=April 2016 |volume=30 |issue=4 |pages=1667–9 |doi=10.1007/s00464-015-4337-0 |pmid=26156615|s2cid=22394114 }}</ref><ref name="Tellapuri">{{cite journal |last1=Tellapuri |first1=S |last2=Park |first2=HS |last3=Kalva |first3=SP |title=Pulmonary arteriovenous malformations. |journal=The International Journal of Cardiovascular Imaging |date=August 2019 |volume=35 |issue=8 |pages=1421–1428 |doi=10.1007/s10554-018-1479-x |pmid=30386957|s2cid=53144651 }}</ref> They have no symptoms in up to 29% of all cases,<ref>{{Cite book | author=Goodenberger DM | title=Fishman's Pulmonary Diseases and Disorders | chapter=Chapter 84 Pulmonary arteriovenous malformations | publisher=McGraw-Hill | year=2008 | page=1470 | edition=4th | isbn=978-0-07-145739-2 }}</ref> however they can give rise to serious complications including [[hemorrhage]], and infection.<ref name="Reichert"/> They are most commonly associated with [[hereditary hemorrhagic telangiectasia]].<ref name="Tellapuri"/>

== Genetics ==
AVMs are usually [[congenital]] and are part of the [[RASopathy]] family of developmental syndromes.
The understanding of the anomaly's [[genetic transmission]] patterns are incomplete, but there are known genetic [[mutation]]s (for instance in the [[epithelial]] line, tumor suppressor [[PTEN gene]]) which can lead to an increased occurrence throughout the body.{{Citation needed|date=March 2023}}

The anomaly can occur due to autosomal dominant diseases, such as [[hereditary hemorrhagic telangiectasia]].<ref>{{Cite web |title=Hereditary hemorrhagic telangiectasia: MedlinePlus Genetics |url=https://medlineplus.gov/genetics/condition/hereditary-hemorrhagic-telangiectasia/ |access-date=2022-07-23 |website=medlineplus.gov |language=en}}</ref>

==Pathophysiology==
In the [[circulatory system]], arteries carry blood away from the heart to the [[lung]]s and the rest of the body, where the blood normally passes through [[capillaries]]—where oxygen is released and waste products like [[carbon dioxide]] ({{CO2}}) absorbed—before veins return blood to the heart.<ref>{{Cite web |date=2021-09-21 |title=Circulatory System: Anatomy and Function |url=https://my.clevelandclinic.org/health/body/21775-circulatory-system |access-date=2023-03-08 |website=[[Cleveland Clinic]] |language=en}}</ref> An AVM interferes with this process by forming a direct connection of the arteries and veins, bypassing the [[capillary bed]].<ref name=":0" /> AVMs can cause intense pain and lead to serious medical problems. Although AVMs are often associated with the brain and spinal cord, they can develop in other parts of the body.<ref name=":0">{{Cite journal |last1=Schimmel |first1=Katharina |last2=Ali |first2=Md Khadem |last3=Tan |first3=Serena Y. |last4=Teng |first4=Joyce |last5=Do |first5=Huy M. |last6=Steinberg |first6=Gary K. |last7=Stevenson |first7=David A. |last8=Spiekerkoetter |first8=Edda |date=2021-08-21 |title=Arteriovenous Malformations—Current Understanding of the Pathogenesis with Implications for Treatment |journal=International Journal of Molecular Sciences |volume=22 |issue=16 |pages=9037 |doi=10.3390/ijms22169037 |issn=1422-0067 |pmc=8396465 |pmid=34445743|doi-access=free }}</ref>

As an AVM lacks the dampening effect of capillaries on the blood flow, the AVM can get progressively larger over time as the amount of blood flowing through it increases, forcing the heart to work harder to keep up with the extra blood flow. It also causes the surrounding area to be deprived of the functions of the capillaries. The resulting tangle of [[blood vessel]]s, often called a ''nidus'' ([[Latin]] for 'nest'), has no capillaries. It can be extremely fragile and prone to bleeding because of the abnormally direct connections between high-pressure arteries and low-pressure veins.<ref>{{Cite journal |last1=Mouchtouris |first1=Nikolaos |last2=Jabbour |first2=Pascal M. |last3=Starke |first3=Robert M. |last4=Hasan |first4=David M. |last5=Zanaty |first5=Mario |last6=Theofanis |first6=Thana |last7=Ding |first7=Dale |last8=Tjoumakaris |first8=Stavropoula I. |last9=Dumont |first9=Aaron S. |last10=Ghobrial |first10=George M. |last11=Kung |first11=David |date=February 2015 |title=Biology of cerebral arteriovenous malformations with a focus on inflammation |journal=Journal of Cerebral Blood Flow and Metabolism|volume=35 |issue=2 |pages=167–175 |doi=10.1038/jcbfm.2014.179 |pmc=4426734 |pmid=25407267}}</ref> One indicator is a pulsing 'whoosh' sound caused by rapid blood flow through arteries and veins, which has been given the term ''bruit'' ([[French language|French]] for 'noise'). If the AVM is severe, this may produce an audible symptom which can interfere with hearing and sleep as well as cause psychological distress.<ref name="NINDS" />

==Diagnosis==
[[File:PleftkidneyAVM1.png|thumb|An arterial venous malformation of the left kidney and a simple cyst of the right kidney]]
[[File:PleftkidneyAVM2.png|thumb|An arterial venous malformation of the left kidney leading to [[aneurysm]]al dilatation of the left [[renal vein]] and [[inferior vena cava]]]]

AVMs are diagnosed primarily by the following [[Medical imaging|imaging]] methods:<ref>{{cite journal |last1=Mokin |first1=Maxim |title=Novel Multimodality Imaging Techniques for Diagnosis and Evaluation of Arteriovenous Malformations |journal=Neurologic Clinics |date=February 2014 |volume=32 |issue=1 |pages=225–236 |doi=10.1016/j.ncl.2013.07.006 |pmid=24287392 |url=https://www.sciencedirect.com/science/article/pii/S0733861913000893 |access-date=February 11, 2023|url-access=subscription }}</ref>
* [[Computed tomography]] (CT) scan is a noninvasive X-ray to view the anatomical structures within the brain to detect blood in or around the brain. A newer technology called [[CT angiography]] involves the injection of [[Radiocontrast agent|contrast]] into the blood stream to view the arteries of the brain. This type of test provides the best pictures of blood vessels through angiography and soft tissues through CT.
* [[Magnetic resonance imaging]] (MRI) scan is a noninvasive test, which uses a magnetic field and radio-frequency waves to give a detailed view of the soft tissues of the brain.
* [[Magnetic resonance angiography]] (MRA) – scans created using magnetic resonance imaging to specifically image the blood vessels and structures of the brain. A magnetic resonance angiogram can be an invasive procedure, involving the introduction of contrast dyes (e.g., [[gadolinium]] MR [[contrast agent]]s) into the vasculature (circulatory system) of a patient using a [[catheter]] inserted into an artery and passed through the blood vessels to the brain. Once the catheter is in place, the contrast dye is injected into the bloodstream and the MR images are taken. Additionally or alternatively, flow-dependent or other contrast-free magnetic resonance imaging techniques can be used to determine the location and other properties of the vasculature.

AVMs can occur in various parts of the body:
* [[human brain|brain]] ([[Cerebral arteriovenous malformation|cerebral AV malformation]])
* [[spleen]]<ref name="pmid17145440">{{cite journal |last1=Agrawal |first1=Aditya |last2=Whitehouse |first2=Richard |last3=Johnson |first3=Robert W. |last4=Augustine |first4=Titus |title=Giant splenic artery aneurysm associated with arteriovenous malformation |journal=Journal of Vascular Surgery |volume=44 |issue=6 |pages=1345–9 |year=2006 |pmid=17145440 |doi=10.1016/j.jvs.2006.06.049 |doi-access=free }}</ref>
* [[human lung|lung]]<ref name="pmid18294908">{{cite journal |last1=Chowdhury |first1=Ujjwal K. |last2=Kothari |first2=Shyam S. |last3=Bishnoi |first3=Arvind K. |last4=Gupta |first4=Ruchika |last5=Mittal |first5=Chander M. |last6=Reddy |first6=Srikrishna |title=Successful Lobectomy for Pulmonary Arteriovenous Malformation Causing Recurrent Massive Haemoptysis |journal=Heart, Lung and Circulation |volume=18 |issue=2 |pages=135–9 |year=2009 |pmid=18294908 |doi=10.1016/j.hlc.2007.11.142 }}</ref><ref name="dupeRef1">{{Cite journal|last1=Cusumano|first1=Lucas R.|last2=Duckwiler|first2=Gary R.|last3=Roberts|first3=Dustin G.|last4=McWilliams|first4=Justin P.|date=2019-08-30|title=Treatment of Recurrent Pulmonary Arteriovenous Malformations: Comparison of Proximal Versus Distal Embolization Technique|journal=CardioVascular and Interventional Radiology|volume=43|issue=1|pages=29–36|doi=10.1007/s00270-019-02328-0|issn=1432-086X|pmid=31471718|s2cid=201675132}}</ref>
* [[kidney]]<ref name="pmid16794894">{{cite journal |last1=Barley |first1=Fay L. |last2=Kessel |first2=David |last3=Nicholson |first3=Tony |last4=Robertson |first4=Iain |title=Selective Embolization of Large Symptomatic Iatrogenic Renal Transplant Arteriovenous Fistula |journal=CardioVascular and Interventional Radiology |volume=29 |issue=6 |pages=1084–7 |year=2006 |pmid=16794894 |doi=10.1007/s00270-005-0265-z |s2cid=9335750 }}</ref>
* [[spinal cord]]<ref name="pmid15730991">{{cite journal |last1=Kishi |first1=K |last2=Shirai |first2=S |last3=Sonomura |first3=T |last4=Sato |first4=M |title=Selective conformal radiotherapy for arteriovenous malformation involving the spinal cord |journal=The British Journal of Radiology |volume=78 |issue=927 |pages=252–4 |year=2005 |pmid=15730991 |doi=10.1259/bjr/50653404 }}</ref>
* [[liver]]<ref name="pmid7650340">{{cite journal |last1=Bauer |first1=Tilman |last2=Britton |first2=Peter |last3=Lomas |first3=David |last4=Wight |first4=Derek G.D. |last5=Friend |first5=Peter J. |last6=Alexander |first6=Graeme J.M. |title=Liver transplantation for hepatic arteriovenous malformation in hereditary haemorrhagic telangiectasia |journal=Journal of Hepatology |volume=22 |issue=5 |pages=586–90 |year=1995 |pmid=7650340 |doi=10.1016/0168-8278(95)80455-2 }}</ref>
* [[intercostal space]]<ref name="pmid17056881">{{cite journal |last1=Rivera |first1=Peter P. |last2=Kole |first2=Max K. |last3=Pelz |first3=David M. |last4=Gulka |first4=Irene B. |last5=McKenzie |first5=F. Neil |last6=Lownie |first6=Stephen P. |title=Congenital Intercostal Arteriovenous Malformation |journal=American Journal of Roentgenology |volume=187 |issue=5 |pages=W503–6 |year=2006 |pmid=17056881 |doi=10.2214/AJR.05.0367 }}</ref>
* [[Iris (anatomy)|iris]]<ref name="pmid16534057">{{cite journal |last1=Shields |first1=Jerry A. |last2=Streicher |first2=Theodor F. E. |last3=Spirkova |first3=Jane H. J. |last4=Stubna |first4=Michal |last5=Shields |first5=Carol L. |title=Arteriovenous Malformation of the Iris in 14 Cases |journal=Archives of Ophthalmology |volume=124 |issue=3 |pages=370–5 |year=2006 |pmid=16534057 |doi=10.1001/archopht.124.3.370 |doi-access= }}</ref>
* [[spermatic cord]]<ref name="pmid17939869">{{cite journal |last1=Sountoulides |first1=Petros |last2=Bantis |first2=Athanasios |last3=Asouhidou |first3=Irene |last4=Aggelonidou |first4=Hellen |title=Arteriovenous malformation of the spermatic cord as the cause of acute scrotal pain: a case report |journal=Journal of Medical Case Reports |volume=1 |pages=110 |year=2007 |pmid=17939869 |pmc=2194703 |doi=10.1186/1752-1947-1-110 |doi-access=free }}</ref>
* extremities – arm, shoulder, etc.

AVMs may occur in isolation or as a part of another disease (for example, [[Sturge-Weber syndrome]] or [[hereditary hemorrhagic telangiectasia]]).<ref name="National Institute of Neurological Disorders and Stroke 2024 s064">{{cite web | title=Arteriovenous Malformations (AVMs) | website=National Institute of Neurological Disorders and Stroke, [[NIH]] | date=February 22, 2024 | url=https://www.ninds.nih.gov/health-information/disorders/arteriovenous-malformations-avms | access-date=March 30, 2024}}</ref>

AVMs have been shown to be associated with [[aortic stenosis]].<ref>{{cite journal |last1=Batur |first1=Pelin |last2=Stewart |first2=William J. |last3=Isaacson |first3=J. Harry |title=Increased Prevalence of Aortic Stenosis in Patients With Arteriovenous Malformations of the Gastrointestinal Tract in Heyde Syndrome |journal=Archives of Internal Medicine |volume=163 |issue=15 |pages=1821–4 |year=2003 |pmid=12912718 |doi=10.1001/archinte.163.15.1821 |doi-access= }}</ref>

Bleeding from an AVM can be relatively mild or devastating. It can cause severe and less often fatal [[stroke]]s.<ref name="NINDS" />

== Treatment ==
[[Cerebral arteriovenous malformation#Treatment|Treatment for AVMs in the brain]] can be symptomatic, and patients should be followed by a neurologist for any seizures, headaches, or focal neurologic deficits. AVM-specific treatment may also involve [[Interventional neuroradiology|endovascular embolization]], neurosurgery or radiosurgery.<ref name=NINDS/>
Embolization, that is, cutting off the blood supply to the AVM with coils, particles, acrylates, or polymers introduced by a radiographically guided catheter, may be used in addition to neurosurgery or radiosurgery, but is rarely successful in isolation except in smaller AVMs.<ref>{{Cite journal|last1=Jafar|first1=Jafar J.|last2=Davis|first2=Adam J.|last3=Berenstein|first3=Alejandro|last4=Choi|first4=In Sup|last5=Kupersmith|first5=Mark J.|date=1993-01-01|title=The effect of embolization with N-butyl cyanoacrylate prior to surgical resection of cerebral arteriovenous malformations|journal=Journal of Neurosurgery|volume=78|issue=1|pages=60–69|doi=10.3171/jns.1993.78.1.0060|pmid=8416244|issn=0022-3085}}</ref> A [[gamma knife]] may also be used.<ref>{{cite web |url=http://www.muh.org.au/ServicesSpecialties/GammaKnife/ForPatients/ConditionsWeTreat.aspx |archive-url=https://web.archive.org/web/20130613164614/http://www.muh.org.au/ServicesSpecialties/GammaKnife/ForPatients/ConditionsWeTreat.aspx |archive-date=2013-06-13 |title=Conditions We Treat |publisher=Macquarie University Hospital }}</ref>

If a cerebral AVM is detected before a stroke occurs, usually the arteries feeding blood into the nidus can be closed off to avert the danger.<ref>{{Cite web |title=Arteriovenous Malformations |url=https://lsom.uthscsa.edu/neurosurgery/clinical-practice/arteriovenous-malformations/ |access-date=2023-06-26 |website=Neurosurgery |language=en-US}}</ref> Interventional therapy may be relatively risky in the short term.<ref name="aruba02">{{cite web |date=January 29, 2014 |title=A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) |url=http://www.ninds.nih.gov/news_and_events/news_articles/ARUBA_trial_results.htm |archive-url=https://web.archive.org/web/20160704222521/http://www.ninds.nih.gov/news_and_events/news_articles/ARUBA_trial_results.htm |archive-date=2016-07-04 |access-date=2023-03-06 |website=[[National Institute of Neurological Disorders and Stroke]]}}</ref>

Treatment of lung AVMs is typically performed with endovascular embolization alone, which is considered the standard of care.<ref name="dupeRef1" />

== Epidemiology ==
The estimated detection rate of AVM in the US general population is 1.4/100,000 per year.<ref>{{cite journal |last1=Stapf |first1=C. |last2=Mast |first2=H. |last3=Sciacca |first3=R.R. |last4=Berenstein |first4=A. |last5=Nelson |first5=P.K. |last6=Gobin |first6=Y.P. |last7=Pile-Spellman |first7=J. |last8=Mohr |first8=J.P. |title=The New York Islands AVM Study: Design, Study Progress, and Initial Results |journal=Stroke |volume=34 |issue=5 |pages=e29–33 |year=2003 |pmid=12690217 |doi=10.1161/01.STR.0000068784.36838.19 |doi-access=free }}</ref> This is approximately one-fifth to one-seventh the incidence of [[intracranial aneurysm]]s. An estimated 300,000 Americans have AVMs, of whom 12% (approximately 36,000) will exhibit symptoms of greatly varying severity.<ref name=NINDS/>

==History==
[[Hubert von Luschka]] (1820–1875) and [[Rudolf Virchow]] (1821–1902) first described arteriovenous malformations in the mid-1800s. [[Herbert Olivecrona]] (1891–1980) performed the first surgical excision of an intracranial AVM in 1932.

==Society and culture==
=== Notable cases ===
* Actor [[Ricardo Montalbán]] was born with spinal AVM.<ref>[https://www.youtube.com/watch?v=x39-hR5rGlc "Ricardo Montalban tribute"] YouTube, acceptance speech video of Easter Seals Lifetime Achievement Award</ref> During the filming of the 1951 film ''[[Across the Wide Missouri (film)|Across the Wide Missouri]]'', Montalbán was thrown from his horse, knocked unconscious, and trampled by another horse which aggravated his AVM and resulted in a painful back injury that never healed. The pain increased as he aged, and in 1993, Montalbán underwent {{frac|9|1|2}} hours of spinal surgery which left him paralyzed below the waist and using a wheelchair.<ref>{{cite web |title=Inside |url=http://www.mahalo.com/Ricardo_Montalban |access-date=17 March 2018 |website=mahalo.com}}</ref>
* Composer and lyricist [[William Finn]] was diagnosed with AVM and underwent gamma knife surgery in September 1992, soon after he won the 1992 [[Tony Award]] for best musical, awarded to ''[[Falsettos]]''.<ref>{{cite news |last=Pall |first=Ellen |date=14 June 1998 |title=The Long-Running Musical of William Finn's Life |newspaper=The New York Times |url=https://www.nytimes.com/1998/06/14/magazine/the-long-running-musical-of-william-finn-s-life.html |access-date=17 March 2018}}</ref> Finn wrote the 1998 Off-Broadway musical ''[[A New Brain]]'' about the experience.
* [[Phoenix Suns]] NBA basketball point guard [[AJ Price]] nearly died from AVM in 2004 while a student at the [[University of Connecticut]].
* On December 13, 2006, US Senator [[Tim Johnson (South Dakota politician)|Tim Johnson]] of South Dakota was diagnosed with AVM and treated at [[George Washington University Hospital]].<ref>{{cite news |title=Sen. Johnson recovering after brain surgery |agency=AP |date=December 14, 2006 |url=https://www.nbcnews.com/id/wbna16199440}}</ref>
* Actor/comedian [[T. J. Miller]] was diagnosed with AVM in 2010; Miller had a seizure and was unable to sleep for a period. He successfully underwent surgery that had a mortality rate of 10%.<ref>{{cite podcast |host=[[Pete Holmes|Holmes, Pete]] |title=You Made It Weird with Pete Holmes |website=[[You Made It Weird]] #2: TJ Miller |publisher=Nerdist Industries |date=October 27, 2011 |url=http://www.nerdist.com/2011/10/you-made-it-weird-2-tj-miller/ |time=37:45 |access-date=December 5, 2012 |archive-url=https://web.archive.org/web/20130212035323/http://www.nerdist.com/2011/10/you-made-it-weird-2-tj-miller/ |archive-date=February 12, 2013 |url-status=dead}}</ref>
* On August 3, 2011, [[Mike Patterson (American football)|Mike Patterson]] of the [[Philadelphia Eagles]] collapsed on the field and had a seizure during a practice, leading to him being diagnosed with AVM.<ref>{{cite web |date=2011-08-04 |title=Mike Patterson's Collapse Reportedly Related To Brain AVM |url=https://www.sbnation.com/2011/8/4/2343821/mike-patterson-collapse-eagles-practice |access-date=17 March 2018 |website=sbnation.com}}</ref>
* Former Florida Gators and Oakland Raiders linebacker [[Neiron Ball]] was diagnosed with AVM in 2011 while playing for [[University of Florida Gators football|Florida]], but recovered and was cleared to play. On September 16, 2018, Ball was placed in a medically induced coma due to complications of the disease, which lasted until his death on September 10, 2019.<ref>{{cite news |date=September 26, 2018 |title=Neiron Ball, former Raiders LB, in medically induced coma after aneurysm |work=ESPN |url=https://www.espn.com/nfl/story/_/id/24796861/neiron-ball-former-oakland-raiders-lb-medically-induced-coma-aneurysm}}</ref>
* Indonesian actress {{illm|Egidia Savitri|id}} died from complications of AVM on November 29, 2013.<ref>{{cite news |last1=Suhendra |first1=Ichsan |title=Pesinetron Egidia Savitri Telah Pergi |language=id |work=KOMPAS.com |agency=Kompas Cyber Media |url=https://entertainment.kompas.com/read/2013/11/29/1920142/Pesinetron.Egidia.Savitri.Telah.Pergi |access-date=15 May 2019}}</ref>
* Jazz guitarist [[Pat Martino]] experienced an AVM and subsequently developed [[amnesia]] and [[manic depression]]. He eventually re-learned to play the guitar by listening to his own recordings from before the [[aneurysm]].<ref>Vida, Vendela. ''Confidence, or the Appearance of Confidence: The Best of the Believer Music Interviews''. No ed. San Francisco, CA: Believer, a Tiny Division of McSweeney's Which Is Also Tiny, 2014. Print.</ref>
* YouTube vlogger [[Nikki Lilly]] (Nikki Christou), winner of the [[Junior Bake Off (series 4)|2016 season]] of ''[[Junior Bake Off]]'' was born with AVM, which has resulted in some facial disfigurement.<ref>{{cite news|title = Junior Bake Off 2016 Winner announced|date = 25 November 2016|access-date = 9 April 2017|url = https://www.bbc.co.uk/mediacentre/latestnews/2016/junior-bake-off-winner|publisher = [[BBC Online]]|website = [[BBC Media Centre]]}}</ref>
* Country music singer [[Drake White]] was diagnosed with AVM in January 2019, and is undergoing treatment.
* Model [[Lucy Markovic]] died in April 2025 at age 27 shortly after undergoing surgery to treat AVM.<ref>{{Cite web |last=Holland |first=Oscar |date=2025-04-11 |title=Lucy Markovic, star of ‘Australia’s Next Top Model,’ dies age 27 |url=https://www.cnn.com/2025/04/11/style/lucy-markovic-australia-model-death-hnk-intl/index.html#openweb-convo |access-date=2025-04-12 |website=CNN |language=en}}</ref>

==See also==
* [[Foix–Alajouanine syndrome]]
* [[Haemangioma]]
* [[Klippel–Trénaunay syndrome]]
* [[Parkes Weber syndrome]]

==References==
{{Reflist}}

{{Medical resources
|  DiseasesDB     = 15235
|  ICD11          = {{ICD11|LA90.3}}, {{ICD11|8B22.40}}, {{ICD11|BD52.1}}, {{ICD11|BA82}}
|  ICD10          = {{ICD10|Q27.3}}, {{ICD10|Q28.0}}, {{ICD10|Q28.2}}, {{ICD10|I77.0}}, {{ICD10|I25.4}}
|  ICD9           = {{ICD9|747.6}}, {{ICD9|747.81}}
|  ICDO           = 
|  OMIM           = 
|  MedlinePlus    = 000779
|  eMedicineSubj  = search
|  eMedicineTopic = Arteriovenous%20Malformation
|  MeshID         = D001165
}}
{{Vascular anomalies}}
{{Congenital vascular defects}}
{{Vascular diseases}}

{{DEFAULTSORT:Arteriovenous Malformation}}
[[Category:Angiogenesis]]
[[Category:Congenital vascular defects]]
[[Category:Gross pathology]]
[[Category:RASopathies]]
[[Category:Vascular anomalies]]