View source for Artificial ventilation

{{Short description|Assisted breathing to support life}}
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{{Infobox medical intervention
| name         = Artificial ventilation
| synonym      =artificial respiration
| image        = Respiratory therapist.jpg
| caption      = Respiratory therapist examining a mechanically ventilated patient on an [[Intensive Care Unit]].
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| specialty    = [[Critical care medicine]]
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'''Artificial ventilation''', also called '''artificial respiration''', is a means of assisting or stimulating [[Respiration (physiology)|respiration]].  Respiration is the overall metabolic process that exchanges gases in the body through pulmonary ventilation, external respiration, and internal respiration.<ref>{{Cite web |title=medilexicon.com, Definition: 'Artificial Ventilation' |url=http://www.medilexicon.com/medicaldictionary.php/?t=98071 |url-status=dead |archive-url=https://web.archive.org/web/20160409091950/http://www.medilexicon.com/medicaldictionary.php/?t=98071 |archive-date=2016-04-09 |access-date=2016-03-30}}</ref><ref>{{cite book |last=Tortora |first=Gerard J |title=Principles of Anatomy and Physiology |author2=Derrickson, Bryan |publisher=John Wiley & Sons Inc. |year=2006}}</ref> Artificial ventilation may take the form of manually providing air for a person who is not [[Breath|breathing]] or is not making sufficient [[respiratory effort]],<ref>{{cite web |title=Artificial Respiration |url=http://www.britannica.com/eb/article-9009713/artificial-respiration |url-status=live |archive-url=https://web.archive.org/web/20070614094502/http://www.britannica.com/eb/article-9009713/artificial-respiration |archive-date=14 June 2007 |access-date=2007-06-15 |publisher=Encyclopædia Britannica}}</ref> or it may take the form of [[mechanical ventilation]] involving the use of a [[Mechanical ventilator|ventilator]] to move air in and out of the lungs when an individual is unable to breathe on their own, such as during [[surgery]] with [[general anesthesia]] or when an individual is in a [[coma]] or [[Major trauma|trauma]].

==Types==
===Manual methods===
{{Further|Mouth-to-mouth resuscitation}}

Pulmonary ventilation is done by manual insufflation of the lungs either by the rescuer blowing into the patient's lungs ([[mouth-to-mouth resuscitation]]), or by using a mechanical device. Mouth-to-mouth resuscitation is also part of [[cardiopulmonary resuscitation]] (CPR) making it an essential skill for [[first aid]]. In some situations, mouth to mouth is also performed separately, for instance in near-[[drowning]] and [[opiate]] overdoses.<ref>{{Cite journal |last1=Newell |first1=Christopher |last2=Grier |first2=Scott |last3=Soar |first3=Jasmeet |date=2018-08-15 |title=Airway and ventilation management during cardiopulmonary resuscitation and after successful resuscitation |journal=Critical Care |language=en |volume=22 |issue=1 |pages=190 |doi=10.1186/s13054-018-2121-y |doi-access=free |issn=1364-8535 |pmc=6092791 |pmid=30111343}}</ref> The performance of mouth to mouth on its own is now limited in most protocols to [[Health professional|health professionals]], whereas lay first aiders are advised to undertake full CPR in any case where the patient is not breathing. This method of insufflation has been proved more effective than methods which involve mechanical manipulation of the patient's chest or arms, such as the [[Silvester method]].<ref>{{cite web|url=http://encarta.msn.com/encyclopedia_761562617/Artificial_Respiration.html |title=Artificial Respiration |publisher=Microsoft Encarta Online Encyclopedia 2007 |access-date=2007-06-15 |archive-url=https://web.archive.org/web/20091030071622/http://encarta.msn.com/encyclopedia_761562617/Artificial_Respiration.html |archive-date=2009-10-30 |url-status=dead }}</ref>

===Mechanical ventilation===
{{Main|Mechanical ventilation}}

Mechanical ventilation is a method to mechanically assist or replace spontaneous [[respiration (physiology)|breathing]].<ref>{{Cite web|url=https://www.nhlbi.nih.gov/health/ventilator|title=What Is a Ventilator? - NHLBI, NIH|website=www.nhlbi.nih.gov|access-date=2016-03-27}}</ref> This involves the use of [[ventilator]] assisted by a [[Nursing|registered nurse]], [[physician]], [[physician assistant]], [[respiratory therapist]], [[paramedic]], or other suitable person compressing a [[bag valve mask]]. Mechanical ventilation is termed "invasive" if it involves any instrument penetrating through the mouth (such as an endo[[tracheal tube]]) or the skin (such as a [[tracheostomy]] tube).<ref>[http://www.hsa.gov.sg/publish/etc/medialib/hsa_library/health_products_regulation/medical_devices/guidance_documents.Par.83962.File.tmp/GN-13-R1%2520Guidance%2520on%2520the%2520Risk%2520Classification%2520of%2520General%2520Medical%2520Devices.pdf GN-13: Guidance on the Risk Classification of General Medical Devices]  {{webarchive|url=https://web.archive.org/web/20140529185327/http://www.hsa.gov.sg/publish/etc/medialib/hsa_library/health_products_regulation/medical_devices/guidance_documents.Par.83962.File.tmp/GN-13-R1%20Guidance%20on%20the%20Risk%20Classification%20of%20General%20Medical%20Devices.pdf |date=May 29, 2014 }}, Revision 1.1. From [[Health Sciences Authority]]. May 2014</ref> There are two main [[modes of mechanical ventilation]] within the two divisions: positive pressure ventilation, where air (or another gas mix) is pushed into the [[Vertebrate trachea|trachea]], and negative pressure ventilation, where air is, in essence, sucked into the lungs.<ref>{{Cite journal |last1=Esteban |first1=Andrés |last2=Ferguson |first2=Niall D. |last3=Meade |first3=Maureen O. |last4=Frutos-Vivar |first4=Fernando |last5=Apezteguia |first5=Carlos |last6=Brochard |first6=Laurent |last7=Raymondos |first7=Konstantinos |last8=Nin |first8=Nicolas |last9=Hurtado |first9=Javier |last10=Tomicic |first10=Vinko |last11=González |first11=Marco |last12=Elizalde |first12=José |last13=Nightingale |first13=Peter |last14=Abroug |first14=Fekri |last15=Pelosi |first15=Paolo |date=2008-01-15 |title=Evolution of Mechanical Ventilation in Response to Clinical Research |url=https://www.atsjournals.org/doi/10.1164/rccm.200706-893OC |journal=American Journal of Respiratory and Critical Care Medicine |language=en |volume=177 |issue=2 |pages=170–177 |doi=10.1164/rccm.200706-893OC |pmid=17962636 |issn=1073-449X|url-access=subscription }}</ref>

[[Tracheal intubation]] is often used for short-term [[mechanical ventilation]]. It's when a tube is inserted through the nose (nasotracheal intubation) or mouth (orotracheal intubation) and advanced into the [[Vertebrate trachea|trachea]]. In most cases tubes with inflatable cuffs are used for protection against leakage and aspiration. Intubation with a cuffed tube is thought to provide the best protection against aspiration. Downside of tracheal tubes is the pain and coughing that follows. Therefore, unless a patient is unconscious or anesthetized, [[sedative]] drugs are usually given to provide tolerance of the tube. Other disadvantages of tracheal intubation include damage to the mucosal lining of the [[nasopharynx]] or [[oropharynx]] and subglottic stenosis.

In an emergency a [[cricothyrotomy]] can be used by health care professionals, where an airway is inserted through a surgical opening in the [[cricothyroid membrane]]. This is similar to a [[tracheostomy]] but a [[cricothyrotomy]] is reserved for emergency access.  This is usually only used when there is a complete blockage of the [[pharynx]] or there is massive maxillofacial injury, preventing other adjuncts being used.<ref name="rsi">{{cite journal |vauthors=Carley SD, Gwinnutt C, Butler J, Sammy I, Driscoll P |title=Rapid sequence induction in the emergency department: a strategy for failure |journal=Emergency Medicine Journal |pmid=11904254 |pmc=1725832 |doi=10.1136/emj.19.2.109 |date=March 2002 |volume=19 |issue=2 |url=http://emj.bmjjournals.com/cgi/content/full/19/2/109 |pages=109–113 |access-date=2007-05-19}}</ref>

===Neurostimulation===
{{Main|Diaphragm pacing}}

A rhythmic pacing of the diaphragm is caused with the help [[Neurostimulation|of electrical impulses]].<ref name="BhimjiDia15">{{cite web |url=http://emedicine.medscape.com/article/1970348-overview#a4 |title=Overview - Indications and Contraindications |work=Medscape - Diaphragm Pacing |author=Bhimji, S. |editor=Mosenifar, Z. |publisher=WebMD LLC |date=16 December 2015 |access-date=19 February 2016}}</ref><ref name="KhannaImp15">{{cite book |chapter-url=https://books.google.com/books?id=lLEvCwAAQBAJ&pg=PA359 |chapter=Chapter 19: Diaphragmatic/Phrenic Nerve Stimulation |title=Implantable Medical Electronics: Prosthetics, Drug Delivery, and Health Monitoring |author=Khanna, V.K. |publisher=Springer International Publishing AG Switzerland |year=2015 |pages=453 |isbn=978-3-319-25448-7 |access-date=19 February 2016}}</ref> Diaphragm pacing is a technique used by persons with spinal cord injuries who are on a mechanical ventilator to aid with breathing, speaking, and overall quality of life. It may be possible to reduce reliance on a mechanical ventilator with diaphragm pacing.<ref>{{Cite journal |last1=Le Pimpec-Barthes |first1=Francoise |last2=Legras |first2=Antoine |last3=Arame |first3=Alex |last4=Pricopi |first4=Ciprian |last5=Boucherie |first5=Jean-Claude |last6=Badia |first6=Alain |last7=Panzini |first7=Capucine Morelot |date=April 2016 |title=Diaphragm pacing: the state of the art |journal=Journal of Thoracic Disease |volume=8 |issue=Suppl 4 |pages=S376–S386 |doi=10.21037/jtd.2016.03.97 |doi-access=free |issn=2072-1439 |pmc=4856845 |pmid=27195135}}</ref> Historically, this has been accomplished through the electrical stimulation of a [[phrenic nerve]] by an implanted receiver/electrode,<ref name="ChenDia05">{{cite journal |title=Diaphragm pacers as a treatment for congenital central hypoventilation syndrome |journal=Expert Review of Medical Devices |author1=Chen, M.L. |author2=Tablizo, M.A. |author3=Kun, S. |author4=Keens, T.G. |volume=2 |issue=5 |pages=577–585 |year=2005 |doi=10.1586/17434440.2.5.577 |pmid=16293069|s2cid=12142444 |url=https://zenodo.org/record/894537 }}</ref> though today an alternative option of attaching [[percutaneous]] wires to the diaphragm exists.<ref name="SynapseUse">{{cite web |url=http://www.synapsebiomedical.com/restricted/PDFs/92-0003-5_A%20Use%20and%20Care%20of%20the%20DPS.pdf |title=Use and Care of the NeuRx Diaphragm Pacing System |publisher=Synapse Biomedical, Inc |access-date=19 February 2016 |archive-date=19 February 2016 |archive-url=https://web.archive.org/web/20160219184729/http://www.synapsebiomedical.com/restricted/PDFs/92-0003-5_A%20Use%20and%20Care%20of%20the%20DPS.pdf |url-status=dead }}</ref>

==History==
The Greek physician [[Galen]] may have been the first to describe artificial ventilation: "If you take a dead animal and blow air through its larynx through a reed, you will fill its bronchi and watch its lungs attain the greatest distention."<ref name=tobin06>{{cite book|last=Colice|first=Gene L|title=Principles & Practice of Mechanical Ventilation|editor=Martin J Tobin|publisher=McGraw-Hill|location=New York|year=2006|edition=2|chapter=Historical Perspective on the Development of Mechanical Ventilation|isbn=978-0-07-144767-6}}</ref> [[Vesalius]] too describes ventilation by inserting a reed or cane into the [[Vertebrate trachea|trachea]] of animals.<ref name="RCP">{{cite journal|author=Chamberlain D |title=Never quite there: a tale of resuscitation medicine |journal=Clin Med |volume=3 |issue=6 |pages=573–7 |year=2003 |pmid=14703040 |pmc=4952587 |doi=10.7861/clinmedicine.3-6-573}}</ref>

It wasn't until 1773, when an English physician [[William Hawes (physician)|William Hawes]] (1736–1808) began publicizing the power of artificial ventilation to resuscitate people who superficially appeared to have drowned. For a year he paid a reward out of his own pocket to any one bringing him a body rescued from the water within a reasonable time of immersion. [[Thomas Cogan]] who was another English physician had become interested in the same subject during a stay at [[Amsterdam]]. 

In the summer of 1774, Hawes and Cogan each brought fifteen friends to a meeting at the Chapter Coffee-house in [[Saint Paul's Cathedral|St Paul's]] Churchyard, where they founded the [[Royal Humane Society]]. Some methods and equipment were similar to methods used today, such as wooden pipes used in the victims nostrils to blow air into the lungs. Or the use of bellows with a flexible tube for blowing tobacco smoke through the anus to revive vestigial life in the victim's intestines, which was discontinued with the eventual further understanding of respiration.<ref>{{Cite web |url=http://exhibits.hsl.virginia.edu/water/ |title=A Watery Grave- Discovering Resuscitation, exhibits.hsl.virginia.edu |website=exhibits.hsl.virginia.edu|access-date=2016-03-30 |archive-date=2017-01-06 |archive-url=https://web.archive.org/web/20170106232354/http://exhibits.hsl.virginia.edu/water/ |url-status=dead }}</ref>

The work of English physician and physiologist [[Marshall Hall (physiologist)|Marshall Hall]] in 1856 suggested against the use of any type of bellows/positive pressure ventilation. These views that were held for several decades. The introduction of a common method of external manual manipulation in 1858, was the "Silvester Method" invented by [[Henry Robert Silvester]]. A method in which a patient is laid on their back and their arms are raised above their head to aid inhalation and then pressed against their chest to aid exhalation. In 1903, another manual technique, the "prone pressure" method, was introduced by Sir [[Edward Sharpey Schafer]].<ref>{{cite encyclopedia|url=https://www.britannica.com/biography/Edward-Albert-Sharpey-Schafer#ref269292|title=Sir Edward Albert Sharpey-Schafer|encyclopedia=Encyclopaedia Britannica|access-date=8 August 2018}}</ref> It involved placing the patient on his stomach and applying pressure to the lower part of the ribs. It was the standard method of artificial respiration taught in Red Cross and similar first aid manuals for decades,<ref name="red">{{cite book|last=American National Red Cross|title=American Red Cross First Aid Text-Book (Revised) |year=1933|publisher=The Blakiston Company|location=Philadelphia|page=108}}</ref> until mouth-to-mouth resuscitation became the preferred technique in mid-century.<ref>{{cite journal|last=Nolte|first=Hans|date=March 1968|title=A New Evaluation of Emergency Methods for Artificial Ventilation|journal=Acta Anaesthesiologica Scandinavica|volume=12|issue=s29|pages=111–25|doi=10.1111/j.1399-6576.1968.tb00729.x|pmid=5674564|s2cid=2547073}}</ref>

The shortcomings of manual manipulation led doctors in the 1880s to come up with improved methods of mechanical ventilation, which included [[George Fell|Dr. George Edward Fell]]'s "Fell method" or "Fell Motor."<ref>[http://buffalostreets.com/tag/fell-alley/ Angela Keppel, Discovering Buffalo, One Street at a Time, Death by Electrocution on Fell Alley?, buffalostreets.com]</ref> It consisted of a bellows and a breathing valve to pass air through a [[tracheotomy]]. He collaborated with Dr. [[Joseph O'Dwyer]] to invent the Fell-O'Dwyer apparatus, which is a bellows instrument for the insertion and extraction of a tube down the patients [[trachea]].<ref>STEVEN J. SOMERSON, MICHAEL R. SICILIA, Historical perspectives on the development and use of mechanical ventilation, AANA Journal February 1992/Vol.60/No.1, page 85</ref><ref>19th century pioneers of intensive therapy in North America. Part 1: George Edward Fell, Crit Care Resusc. 2007 Dec;9(4):377-93 [https://www.ncbi.nlm.nih.gov/pubmed/18052905 abstract]</ref> Such methods were still looked upon as harmful and were not adopted for many years.

In 2020, the supply of mechanical ventilation became a central question for public health officials due to 
[[2019–20 coronavirus pandemic related shortages]].

==See also==
*[[2019–20 coronavirus pandemic related shortages#Mechanical ventilation]]
*[[Cardiopulmonary resuscitation]]
*[[Medical emergency]]
*[[Medical ventilator]]
*[[Two-balloon experiment]]
*[[Charles Hederer]], inventor of the pulmoventilateur
*[[Edward Albert Sharpey-Schafer]]

==References==
{{Reflist}}

==External links==
{{Commons category-inline}}
*[http://www.emedicine.com/med/topic3370.htm e-Medicine], article on mechanical ventilation along with technical information.
*[https://web.archive.org/web/20181005023224/http://www.post-polio.org/ivun/index.html International Ventilator Users Network (IVUN)], Resource of information for users of home mechanical ventilation.
*[https://smhs.gwu.edu/icu/sites/icu/files/Mech%20Vent%20SHort%20PDF.pdf ''Mechanical Ventilation,''] {{Webarchive|url=https://web.archive.org/web/20200727041359/https://smhs.gwu.edu/icu/sites/icu/files/Mech%20Vent%20SHort%20PDF.pdf |date=2020-07-27 }} (detailed slideshow presentation), by Amirali Nader, MD FCCP,  Critical Care Medicine, Suburban Hospital, Johns Hopkins Medicine.

{{Mechanical ventilation}}

{{Intensive care medicine}}
{{Respiratory system procedures}}
{{Authority control}}

[[Category:Mechanical ventilation]]
[[Category:Emergency medicine]]
[[Category:Intensive care medicine]]
[[Category:Emergency medical services]]
[[Category:Respiratory system procedures]]
[[Category:Respiratory therapy]]
[[Category:First aid]]