View source for Oxycodone/paracetamol

{{Short description|Pain medication}}
{{Redirect2|Percocet|Percs|the band|Percocettes|the supercomputer technology|PERCS|the cleaning chemical PERC|tetrachloroethylene|}}
{{Use dmy dates|date=October 2022}}
{{cs1 config |name-list-style=vanc |display-authors=6}}
{{Drugbox
| Verifiedfields     = changed
| Watchedfields      = changed
| verifiedrevid      = 455187452
| type               = combo
| image              = 
| alt                = 
| caption            = 

<!-- Combo data -->
| component1         = Oxycodone
| class1             = [[Opioid|Opioid analgesic]]
| component2         = Acetaminophen
| class2             = [[Anilides|Anilide analgesic]]

<!-- Clinical data -->
| tradename          = Percocet, others
| Drugs.com          = {{ubl
  | {{drugs.com|parent|acetaminophen-and-oxycodone}}
  | {{drugs.com|ppa|oxycodone-and-acetaminophen}}
  }}
| MedlinePlus        = 
| DailyMedID         = Oxycodone hydrochloride and acetaminophen
| pregnancy_AU       = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_category = 
| routes_of_administration = [[Oral administration|By mouth]]
| ATC_prefix         = N02
| ATC_suffix         = AJ17

<!-- Legal status -->
| legal_AU           = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled -->
| legal_AU_comment   = 
| legal_BR           = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F -->
| legal_BR_comment   = 
| legal_CA           = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment   = 
| legal_DE           = <!-- Anlage I, II, III or Unscheduled -->
| legal_DE_comment   = 
| legal_NZ           = <!-- Class A, B, C -->
| legal_NZ_comment   = 
| legal_UK           = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->
| legal_UK_comment   = 
| legal_US           = Schedule II
| legal_US_comment   = <ref name="Percocet FDA label">{{cite web | title=Percocet- oxycodone hydrochloride and acetaminophen tablet | website=DailyMed | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4dd36cf5-8f73-404a-8b1d-3bd53bd90c25 | access-date=17 October 2021}}</ref>
| legal_EU           = 
| legal_EU_comment   = 
| legal_UN           = <!-- N I, II, III, IV / P I, II, III, IV -->
| legal_UN_comment   = 
| legal_status       = <!-- For countries not listed above -->

<!--Identifiers-->
| CAS_number_Ref     = {{cascite|correct|??}}
| CAS_number         = 330988-72-2
| DrugBank           = 
| ChemSpiderID_Ref   = {{chemspidercite|correct|chemspider}}
| ChemSpiderID       = 4881971
| KEGG               = D02153
}}

'''Oxycodone/paracetamol''',<!-- NOTE: DO NOT CHANGE TO ACETAMINOPHEN, per [[WP:TITLE]] --> sold under the brand name '''Percocet''' among others,<ref>{{cite web | title=Oxycodone / Acetaminophen: Uses, Dosage & More | website=Drugs.com | date=5 March 2023 | url=https://www.drugs.com/acetaminophen-and-oxycodone.html | access-date=7 February 2025}}</ref> is a [[fixed-dose combination]] of the opioid [[oxycodone]] with [[paracetamol]] (acetaminophen), used to treat moderate to severe [[pain]].<ref name="Percocet FDA label" />

In 2023, it was the 93rd most commonly prescribed medication in the United States, with more than 7{{nbsp}}million prescriptions.<ref name="Top300Drugs">{{cite web | title=Top 300 of 2023 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=12 August 2025 | archive-date=12 August 2025 | archive-url=https://web.archive.org/web/20250812130026/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Acetaminophen; Oxycodone Drug Usage Statistics, United States, 2013 - 2023 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/AcetaminophenOxycodone | access-date = 18 August 2025 }}</ref>

==History==
The United States [[Food and Drug Administration]] (FDA) first approved oxycodone/paracetamol in 1976, under application ANDA 085106.<ref>{{cite web | title=Percocet: FDA-Approved Drugs | website=U.S. [[Food and Drug Administration]] (FDA) | url=https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=085106 | access-date=17 October 2021}}</ref>

== Society and culture ==
Percocet is often called '''perc''' for short.<ref name="Vulture">{{cite web |last1=Levy |first1=Lauren |title=These Are the Drugs Influencing Pop Culture Now |url=https://www.vulture.com/2018/02/the-drugs-influencing-pop-culture-right-now.html |website=[[Vulture (website)|Vulture]] |access-date=5 June 2025 |archive-url=https://web.archive.org/web/20250204015710/https://www.vulture.com/2018/02/the-drugs-influencing-pop-culture-right-now.html |archive-date=2025-02-04 |language=en |date=6 February 2018 |quote=Also known as: Percs, blue dynamite. [...] Percocet has become a favorite reference in rap music [...] The rapper Future elevated Perc-worship to a new status in the chorus of his hit 'Mask Off' |url-status=live}}</ref><ref>{{cite web |title=Oxycodone |url=https://www.dea.gov/factsheets/oxycodone |website=[[United States Drug Enforcement Administration|US DEA]] |access-date=5 June 2025 |archive-url=https://web.archive.org/web/20250418164125/https://www.dea.gov/factsheets/oxycodone |archive-date=2025-04-18 |language=en |quote=Street Title: Hillbilly Heroin, Kicker, OC, Ox, Roxy, Perc, Oxy}}</ref> Since the early 2010s, the medication has commonly been name-dropped in songs from multiple genres, such as [[Future (rapper)|Future]]'s 2017 song "[[Mask Off]]".<ref name="Vulture" />

=== Implicated in deaths ===
In June 2009, an FDA advisory panel recommended that Percocet, [[Vicodin]], and every other combination of acetaminophen with [[narcotic]] [[analgesics]]<ref>{{cite web|url=http://www.webmd.com/pain-management/news/20090701/fda-may-restrict-acetaminophen|title=FDA May Restrict Acetaminophen|work=WebMD}}</ref> be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to [[acetaminophen overdose]] and associated liver damage.<ref>{{cite news| url=https://www.nytimes.com/2009/07/01/health/01fda.html | work=[[The New York Times]] | title=Ban Is Advised on 2 Top Pills for Pain Relief | first=Gardiner | last=Harris | date=30 June 2009 | access-date=22 May 2010}}</ref>

In December 2009, a study found a fivefold increase in oxycodone-related deaths in [[Ontario, Canada]] (mostly accidental) between 1991 and 2007; this led to a doubling of all opioid-related deaths in Ontario over the same period.<ref>{{cite journal | vauthors = Dhalla IA, Mamdani MM, Sivilotti ML, Kopp A, Qureshi O, Juurlink DN | title = Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone | journal = CMAJ | volume = 181 | issue = 12 | pages = 891–6 | date = December 2009 | pmid = 19969578 | pmc = 2789126 | doi = 10.1503/cmaj.090784 }}</ref><ref>{{cite journal | vauthors = Fischer B, Rehm J | title = Deaths related to the use of prescription opioids | journal = CMAJ | volume = 181 | issue = 12 | pages = 881–2 | date = December 2009 | pmid = 19969577 | pmc = 2789122 | doi = 10.1503/cmaj.091791 }}</ref><ref>{{cite journal|journal=Canadian Medical Association Journal |date=7 December 2009 |title=Deaths from opioid use have doubled; five-fold increase in oxycodone deaths |access-date=31 May 2012 |url=https://www.sciencedaily.com/releases/2009/12/091207123105.htm}}</ref>

== References ==
{{Reflist}}

{{Analgesics}}
{{Anti-inflammatory products}}
{{Opioidergics}}
{{Drug use}}
{{Portal bar | Medicine}}
{{Authority control}}

{{DEFAULTSORT:Oxycodone Paracetamol}}
[[Category:Combination analgesics]]
[[Category:Hepatotoxins]]