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'''Ruffini''' is an Italian surname. Notable people with the surname include:

*[[Angelo Ruffini]] (1864–1929), Italian histologist and embryologist
*[[Attilio Ruffini]] (1924–2011), Italian politician
*[[Ernesto Ruffini]] (1888–1967), Archbishop of Palermo
*[[Frederick Ernst Ruffini]] (1851-1885), American architect
*[[Giovanni Ruffini]] (1807–1881), Italian poet and librettist
*[[Giulano Ruffini]] (born 1945), French art collector
*Giuseppe or [[Joseph Ruffini]] (1690–1749), Italian-Austrian painter
*[[Luca Ruffini]] (born 1997), Italian footballer
*[[Oscar Ruffini]] (1858-1957), American architect
*[[Paolo Ruffini (mathematician)]] (1765–1822), Italian mathematician and philosopher
*[[Paolo Ruffini (actor)]] (born 1978), Italian actor and presenter
*[[Patrick Ruffini]], political pollster and strategist
*[[Sandro Ruffini]] (1889–1954), Italian actor and voice actor
*[[Remo Ruffini]] (born 1942), Italian astrophysicist
*[[Remo Ruffini (businessman)]] (born 1961), Italian billionaire businessman
*[[Silvia Ruffini]] (1475–1561), Italian noble woman and mistress of Cardinal Alessandro Farnese
*[[Simone Ruffini]] (born 1989), Italian swimmer
*[[Stefano Ruffini]] (1963–2006), Italian singer and voice actor

==See also==
*[[Eugen Ruffínyi]] (1846–1924), Slovak mining engineer and amateur speleologist; the original family name was probably "Ruffini"

{{surname|Ruffini}}

[[Category:Italian-language surnames]]