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{{short description|Toxic chemical leak in Italy in 1976}}
[[File:SEVESO-1976.jpg|275px|thumb|A [[Carabinieri|Carabiniere]] in a biohazard suit installs signs warning of the presence of toxic chemicals.]]
The '''Seveso disaster''' was an [[industrial accident]] that occurred around 12:37 on 10 July 1976, in a small [[Chemical plant|chemical manufacturing plant]] approximately {{convert|20|km|mi|0}} north of [[Milan]] in the [[Lombardy]] region of [[Italy]]. It resulted in the highest known exposure to [[2,3,7,8-tetrachlorodibenzo-p-dioxin]] (TCDD) in residential populations,<ref>{{cite journal|title=Relationship of Serum TCDD Concentrations and Age at Exposure of Female Residents of Seveso, Italy|journal=Environmental Health Perspectives|first1=Brenda |last1=Eskenazi |first2=Paolo |last2=Mocarelli |first3=Marcella |last3=Warner |first4=Larry |last4=Needham |first5=Donald G. Jr. |last5=Patterson |first6=Steven |last6=Samuels |first7=Wayman |last7=Turner |first8=Pier Mario |last8=Gerthoux |first9=Paolo |last9=Brambilla |volume=112|issue=1|pmc=1241792|pmid=14698926|date=January 2004|pages=22–7|doi=10.1289/ehp.6573}}</ref> which gave rise to numerous scientific studies and standardized industrial [[safety regulations]], including the [[European Union]]'s [[Directive 2012/18/EU|Seveso III Directive]]. This accident was ranked eighth in a list of the worst man-made [[environmental disaster]]s by [[Time (magazine)|''Time'']] magazine in 2010.<ref>{{cite web|url=https://content.time.com/time/specials/packages/completelist/0,29569,1986457,00.html|title=Top 10 Environmental Disasters}}</ref>

==Location of disaster==
The Seveso disaster was named after [[Seveso]], the community most affected, which had a population of 17,000 in 1976. Other affected neighbouring communities were [[Meda, Lombardy|Meda]] (19,000), [[Desio]] (33,000), [[Cesano Maderno]] (34,000) and to a lesser extent [[Barlassina]] (6,000) and [[Bovisio-Masciago]] (11,000).<ref>{{cite web|url=http://archive.unu.edu/unupress/unupbooks/uu21le/uu21le09.htm|title=4 Seveso: A paradoxical classic disaster|publisher=[[United Nations University]]|author=B. De Marchi|author2=S. Funtowicz |author3=J. Ravetz }}</ref> The industrial plant, located in Meda, was owned by the company {{lang|it|Industrie Chimiche Meda Società Azionaria|italic=no}} (Meda Chemical Industries [[S.A. (corporation)|S.A.]], or ICMESA), a subsidiary of [[Givaudan]], which in turn was a subsidiary of [[Hoffmann-La Roche]] (Roche Group). The factory building had been built many years earlier and the local population did not perceive it as a potential source of danger. Moreover, although several exposures of populations to [[Dioxins and dioxin-like compounds|dioxins]] had occurred before, mostly in industrial accidents, they were of a more limited scale.

==Chemical events==
The accident occurred in the chemical plant's Building B. The chemical [[2,4,5-trichlorophenol]] ('''2''') was produced there from [[1,2,4,5-tetrachlorobenzene]] ('''1''') by the [[nucleophilic aromatic substitution]] reaction with [[sodium hydroxide]]. The 2,4,5-trichlorophenol was intended as an intermediate for [[hexachlorophene]].<ref name = "Homberger">{{cite journal | last = Homberger | first = E. |author2=Reggiani, G. |author3=Sambeth, J. |author4=Wipf, H. K. | title = The Seveso Accident: Its Nature, Extent and Consequences | journal = Ann. Occup. Hyg. | volume = 22 | issue = 4 | pages = 327–370 | publisher = [[Pergamon Press]] | year = 1979 | doi = 10.1093/annhyg/22.4.327 | pmid = 161954 }}</ref>

:[[File:Seveso reaction.PNG|thumb|left|500px|Overall reaction scheme: conversion of 1,2,4,5-tetrachlorobenzene ('''1''') to 2,4,5-trichlorophenol ('''2'''), with byproduct TCDD ('''3''')]]{{clear-left}}

The reaction temperature was achieved by passing the [[steam]] exhaust from the onsite electricity generation [[turbine]] through an external [[heating coil]] installed on the [[chemical reactor vessel]]. The exhaust steam pressure was normally 12 [[Bar (unit)|bar]] and temperature 190&nbsp;°C, which resulted in a reaction mixture temperature of 158&nbsp;°C, very close to its boiling point of 160&nbsp;°C. Safety testing showed the onset of an [[exothermic reaction|exothermic]] (heat-releasing) [[side reaction]] if the reaction mixture temperature reached 230&nbsp;°C. Crucially, no steam temperature reading was made available to plant operators responsible for the reactor.

The chemical-release accident occurred when a [[Batch production|batch process]] was stopped before the completion of the final step of removal of [[ethylene glycol]] from the reaction mixture by [[distillation]]. The process was stopped due to conformance with an Italian law requiring the shutdown of plant operations over the weekend. Other parts of the site had already started to close down as the processing of other batches finished, which reduced power consumption across the plant, causing a dramatic drop in the load on the turbine and a consequent increase in the temperature of the exhaust steam to around 300&nbsp;°C. This hotter-than-normal steam then heated the portion of the metal wall of the accident reactor above the level of the liquid within it to the same temperature. Not having a steam temperature reading among their instruments, the operators of the reactor were unaware of the presence of this additional heating, and they stopped the batch as they normally would by isolating the steam and turning off the stirrer in the reactor vessel. The abnormally hot upper region of the reactor jacket then heated the adjacent reaction mixture. With the stirrer not running, the heating was highly localised to just the portion of the upper layers of the reaction mixture adjacent to the reactor wall. The local temperature increased to above the critical temperature for the exothermic side reaction seen in testing. Additionally, the critical temperature proved to be only 180&nbsp;°C, 50&nbsp;°C lower than believed. At that lower critical temperature, an exothermic [[Thermal decomposition|decomposition]] began, releasing more heat and leading to the onset of a rapid [[Thermal runaway|runaway reaction]] when the temperature reached 230&nbsp;°C seven hours later.<ref>{{cite book |first=Trevor |last=Kletz |author-link=Trevor Kletz |title=What Went Wrong? Case Histories of Process Plant Disasters |date=1998 |publisher=Gulf |isbn=0-88415-920-5}}</ref><ref name = "Kletz">{{cite book | last = Kletz | first = Trevor A. | author-link = Trevor Kletz |title=Learning from Accidents |edition=3rd |publisher=Gulf Professional | year = 2001 | location = Oxford U.K. | pages = 103–109 |chapter=Ch. 9) | chapter-url = https://books.google.com/books?id=zulmgUi5_aEC&pg=PA103 | isbn = 978-0-7506-4883-7}}</ref>

The reactor [[relief valve]] eventually opened, causing the aerial release of 6 tonnes of chemicals, which settled over {{Convert|18|km2|abbr=on}} of the surrounding area.<ref>{{cite web| url=http://www.siznursing.be/index.php?preaction=joint&id_joint=71790| title=Seveso – 30 Years After, A Chronology of Events| publisher=Roche Group}}</ref> The cloud of substances released contained sodium hydroxide, ethylene glycol, sodium trichlorophenate, and approximately 15 to 30&nbsp;kg of TCDD ('''3''').<ref name=":1">{{Cite journal |last1=Eskenazi |first1=Brenda |last2=Warner |first2=Marcella |last3=Brambilla |first3=Paolo |last4=Signorini |first4=Stefano |last5=Ames |first5=Jennifer |last6=Mocarelli |first6=Paolo |date=2018-12-01 |title=The Seveso accident: A look at 40 years of health research and beyond |journal=Environment International |volume=121 |issue=Pt 1 |pages=71–84 |doi=10.1016/j.envint.2018.08.051 |issn=0160-4120 |pmc=6221983 |pmid=30179766|bibcode=2018EnInt.121...71E }}</ref> At the nominal reaction temperature, TCDD is normally seen only in trace amounts of less than 1 [[Parts per million|ppm]] (parts per million).<ref>{{cite journal | last = Milnes | first = M. H. | title = Formation of 2,3,7,8-Tetrachlorodibenzodioxin by Thermal Decomposition of Sodium 2,4,5-Trichlorophenate | journal = [[Nature (journal)|Nature]] | volume = 232 | pages = 395–396 | publisher = [[Nature Publishing Group]] | date = 6 August 1971 | doi = 10.1038/232395a0 | pmid = 16063057 | issue = 5310| bibcode = 1971Natur.232..395M | s2cid = 4215351 }}</ref>{{clarify|Parts of what per million of what??? Define "ppm" unambigously, otherwise it can be in terms of anything: mass, volume, mole, ...|date=October 2022}} However, in the higher-temperature conditions associated with the runaway reaction, TCDD production reached 166 ppm or more.<ref>{{cite journal | last = Hay | first = Alastair | title = Séveso: the crucial question of reactor safety | journal = [[Nature (journal)|Nature]] | volume = 281 | issue = 5732 | page = 521 | publisher = [[Nature Publishing Group]] | date = 18 October 1979 | doi = 10.1038/281521a0 | bibcode = 1979Natur.281..521H | s2cid = 38191411 | doi-access = free }}</ref>{{clarify|Parts of what per million of what??? Define "ppm" unambigously, otherwise it can be in terms of anything: mass, volume, mole, ...|date=October 2022}}

==Immediate effects==
The affected area was split into zones A, B, and R in decreasing order of surface soil concentrations of TCDD. Zone A was further split into 7 sub-zones. The local population was advised not to touch or eat locally grown [[fruit]]s or [[vegetable]]s.
*Zone A had a TCDD soil concentration of &gt; 50 micrograms per square metre (μg/m<sup>2</sup>); it had between 736<ref name=":1" /><ref name=":2">{{Cite journal |last1=Eskenazi |first1=Brenda |last2=Mocarelli |first2=Paolo |last3=Warner |first3=Marcella |last4=Samuels |first4=Steven |last5=Vercellini |first5=Paolo |last6=Olive |first6=David |last7=Needham |first7=Larry |last8=Patterson |first8=Donald |last9=Brambilla |first9=Paolo |date=2000-05-01 |title=Seveso Women's Health Study: a study of the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive health |url=https://www.sciencedirect.com/science/article/pii/S0045653599003768 |journal=Chemosphere |volume=40 |issue=9 |pages=1247–1253 |doi=10.1016/S0045-6535(99)00376-8 |pmid=10739069 |bibcode=2000Chmsp..40.1247E |issn=0045-6535|url-access=subscription }}</ref> – 753<ref name=":3">{{Cite journal |last1=Assennato |first1=G |last2=Cervino |first2=D |last3=Emmett |first3=EA |last4=Longo |first4=G |last5=Merlo |first5=F |date=January 1, 1989 |title=Follow-up of subjects who developed chloracne following TCDD exposure at Seveso |url=https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajim.4700160203 |journal=American Journal of Industrial Medicine |volume=16 |issue=2 |pages=119–125 |doi=10.1002/ajim.4700160203 |pmid=2773943 |via=Wiley|url-access=subscription }}</ref>  residents.
*Zone B had a TCDD soil concentration of between 5 and 50&nbsp;μg/m<sup>2</sup>; it had 4737 residents.<ref name=":1" />
*Zone R had a negligible concentration of TCDD or up to &lt; 5&nbsp;μg/m<sup>2</sup>; it had 31,800 residents.<ref name=":1" />

The population who lived in the path of the aerosol cloud reportedly developed acute symptoms such as headaches, nausea, and eye irritation. 19 children in the area were hospitalized with skin lesions.<ref name=":3" /> 500 residents in the area were treated for acute skin irritation. The accident also immediately caused 193 individuals to develop [[chloracne]], none of whom were employed at the ICMESA plant.<ref name=":3" />  By the 2nd of August, all residents in Zone A were evacuated and the area was fenced off, however, evacuation only began 15 days after the accident took place.<ref name=":1" /> After evacuation, all residents of Zone A were medically examined and laboratory tests were performed, Ultimately, 640<ref>{{Cite web |last=Roche Group |date=January 1997 |title=Seveso 20 years after |url=https://assets.roche.com/f/176343/a26a708398/seveso_20years_after.pdf |archive-url=https://web.archive.org/web/20231117103254/https://assets.roche.com/f/176343/a26a708398/seveso_20years_after.pdf |archive-date=November 17, 2023 |access-date=November 17, 2023}}</ref> individuals living in the region were affected with chloracne.

An estimated 25% of all animals in Zone A died immediately after exposure to the aerosol cloud,<ref name=":2" /> and by the end of July, 3,300 animals, mostly poultry and rabbits, were found dead.<ref name=":3" /> Emergency slaughtering commenced to prevent TCDD from entering the [[food chain]], and by 1978 over 80,000 animals had been culled.<ref name=":3" />

The residents of Zone B were not evacuated but were given warnings to refrain from eating locally-grown produce and poultry. The residents of Zone B were given medical examinations and clinical laboratory tests. Pregnant women and children under 12 years old were relocated daily.<ref name=":1" />

Residents of Zone R were only warned to not eat locally grown foods.<ref name=":1" />

An advice center was set up for pregnant women, of whom 26{{citation needed|date=October 2020}} opted for an [[teratogenicity|abortion]] (which was [[Abortion in Italy|legal]] in special cases) after consultation. Another 460 women continued their pregnancies without problems, their children not showing any sign of malformation.{{citation needed|date=March 2016}} Herwig von Zwehl (Technical Director of ICMESA) and Paolo Paoletti (director of production at ICMESA) were arrested. Two government commissions were established to develop a plan for [[Quarantine|quarantining]] and [[Decontamination|decontaminating]] the area, for which the Italian government allotted 40 billion lire (US$47.8 million).  This amount was tripled two years later.

==Studies on immediate and long-term health effects==
A 1991 study,<ref>
{{cite journal  | last = Bertazzi  | first = Pier Alberto  | title = Long-term effects of chemical disasters. Lessons and results from Seveso  | journal = The Science of the Total Environment  | volume = 106   | issue = 1–2  | pages = 5–20  | year = 1991  | doi = 10.1016/0048-9697(91)90016-8  | pmid = 1835132 | bibcode = 1991ScTEn.106....5B }}
</ref> fourteen years after the accident, sought to assess the effects on the thousands of persons that had been exposed to dioxin.  The most evident adverse health effect ascertained was [[chloracne]] (193 cases). Other early effects noted were peripheral [[neuropathy]] and [[liver enzyme induction]]. The ascertainment of other, possibly severe [[sequelae]] of dioxin exposure (e.g., birth defects) was hampered by inadequate information; however, generally, no increased risks were evident.

A study published in 1998 concluded that chloracne (nearly 200 cases with a definite exposure dependence) was the only effect established with certainty. Early health investigations including liver function, immune function, neurologic impairment, and reproductive effects yielded inconclusive results.

An [[excess mortality rate]] from cardiovascular and respiratory diseases was uncovered, and an excess of [[diabetes]] cases was also found. Results of [[cancer]] incidence and mortality follow-up showed an increased occurrence of cancer of the [[gastrointestinal]] sites and of the [[Lymphatic tissue|lymphatic]] and [[hematopoietic tissue]]. Results cannot be viewed as final or comprehensive, however, because of various limitations: the lack of individual exposure data, short latency period, and small population size for certain cancer types.

A 2001 study confirmed in victims of the disaster, that dioxin is [[carcinogen]]ic to humans and corroborate its association with [[cardiovascular]]- and [[endocrine]]-related effects. In 2009, an update including 5 more years (up to 1996) found an increase in "lymphatic and hematopoietic tissue neoplasms" and increased [[breast cancer]].<ref>{{Cite journal| last1 = Pesatori | first1 = A.| last2 = Consonni | first2 = D.| last3 = Rubagotti | first3 = M.| last4 = Grillo | first4 = P.| last5 = Bertazzi | first5 = P.| title = Cancer incidence in the population exposed to dioxin after the "Seveso accident": twenty years of follow-up| journal = Environmental Health| volume = 8| issue = 1| page= 39| year = 2009| pmid = 19754930| pmc = 2754980| doi = 10.1186/1476-069X-8-39| bibcode = 2009EnvHe...8...39P| doi-access = free}}[http://www.ehjournal.net/content/8/1/39 Free full-text]</ref>

A 2008 study<ref>{{Cite journal|last1=Baccarelli|first1=Andrea|last2=Giacomini|first2=Sara M.|last3=Corbetta|first3=Carlo|last4=Landi|first4=Maria Teresa|last5=Bonzini|first5=Matteo|last6=Consonni|first6=Dario|last7=Grillo|first7=Paolo|last8=Jr|first8=Donald G. Patterson|last9=Pesatori|first9=Angela C.|last10=Bertazzi|first10=Pier Alberto|date=2008-07-29|title=Neonatal Thyroid Function in Seveso 25 Years after Maternal Exposure to Dioxin|journal=PLOS Medicine|language=en|volume=5|issue=7|pages=e161|doi=10.1371/journal.pmed.0050161|issn=1549-1676|pmc=2488197|pmid=18666825 |doi-access=free }}</ref> evaluated whether maternal exposure is associated with modified neonatal [[thyroid function]] in the highly exposed population in Seveso and concluded that environmental contaminants such as dioxins have a long-lasting capability to modify neonatal thyroid function after the initial exposure.

The male children of mothers who were, during pregnancy of those children, exposed to high levels of toxic dioxins due to the Seveso disaster, have been found to have lower-than-average [[sperm counts]].  This result of the underlying Seveso study has been noted to provide the most pronounced evidence for prenatal exposure to an environmental chemical causing low sperm counts.<ref>{{cite news|url=https://www.independent.co.uk/news/science/out-for-the-count-why-levels-of-sperm-in-men-are-falling-1954149.html|title=Out for the count: Why levels of sperm in men are falling|newspaper=The Independent|date=25 April 2010}}</ref>

==Cleanup operations==
{{unreferenced section|date=July 2012}}
In January 1977, an action plan consisting of scientific analysis, economic aid, medical monitoring and restoration/decontamination was completed. Shortly after ICMESA began to pay the first compensations to those affected. Later that spring decontamination operations were initiated and in June a system for epidemiological health monitoring for 220,000 people was launched. They then used trichlorophenol to make a drug to fight skin infections, which they tested in dogs.

In June 1978, the Italian government raised its special loan from 40 to 115 billion lire. By the end of the year, most individual compensation claims had been settled [[out of court]]. On 5 February 1980, [[Paolo Paoletti]] (the Director of Production at ICMESA) was shot and killed in [[Monza]] by a member of the Italian radical left-wing terrorist organization [[Prima Linea]].<ref>{{cite web| first=F| last=Robbe| url=http://www.itacaedizioni.it/catalogo/seveso-1976/| title=Seveso 1976. Oltre la diossina| publisher=Itaca| date=2016| pages=119–120}}</ref> 
  
On 19 December 1980, representatives of the Region of Lombardy/Italian Republic and Givaudan/ICMESA signed a compensation agreement in the presence of the prime minister of Italy, [[Arnaldo Forlani]]. The total amount would reach 20 billion [[Italian lira|lire]].

===Waste from the cleanup===
The waste from the clean up of the plant was a mixture of [[protective clothing]] and chemical residues from the plant. This waste was packed into waste drums which had been designed for the storage of [[nuclear waste]]. It was agreed that the waste would be disposed of legally.

To this end, in spring 1982, the firm Mannesmann Italiana was contracted to dispose of the contaminated chemicals from Zone A.  Mannesmann Italiana made it a condition that Givaudan would not be notified of the disposal site which prompted Givaudan to insist that a [[notary public]] certify the disposal. On 9 September, 41 barrels of toxic waste left the ICMESA premises. On 13 December, the notary gave a sworn statement that the barrels had been disposed of in an approved way.

However, in February 1983, the programme ''A Bon Entendeur'' on [[Télévision Suisse Romande]], a [[French language]] [[Switzerland|Swiss]] television channel, followed the route of the barrels to [[Saint-Quentin, Aisne|Saint-Quentin]] in northern [[France]] where they disappeared. A public debate ensued in which numerous theories were put forward when it was found that Mannesmann Italiana had hired two subcontractors to dispose of the toxic waste. On 19 May, the 41 barrels were found in an unused [[abattoir]] in [[Anguilcourt-le-Sart]], a village in northern France. From there they were transferred to a French military base near [[Sissonne]]. The Roche Group (parent firm of Givaudan) took it upon itself to properly dispose of the waste. On 25 November, over nine years after the disaster, the Roche Group issued a public statement that the toxic waste consisting of 42 barrels (one was added earlier that year) had all been [[incinerate]]d in [[Switzerland]].  According to ''[[New Scientist]]'', it was thought that the high chlorine content of the waste might cause damage to the high-temperature incinerator used by Roche, but Roche stated that they would burn the waste in the incinerator and repair it afterward if it were damaged. They stated that they wanted to take responsibility for the safe destruction of the waste.

===Criminal court case===
{{Expand section|Explaining what this criminal court case was about: the cleanup operations (it's in a sub-section) or the general disaster?|date=September 2022}}
In September 1983, the Criminal Court of Monza sentenced five former employees of ICMESA or its parent company, [[Givaudan]], to prison sentences ranging from 2.5 years to 5 years. They all appealed.

In May 1985, the Court of Appeal in Milan found three of the five accused not guilty; the two still facing prosecution appealed to the [[Supreme Court of Cassation (Italy)|Supreme Court]] in Rome.

On 23 May 1986, the Supreme Court in Rome confirmed the judgment against the two remaining defendants, even though the prosecuting attorney had called for their acquittal.

==Aftermath==
After the incident, ICMESA initially refused to admit that the dioxin release had occurred. At least a week passed before a public statement was issued that dioxin had been emitted, and another week passed before an evacuation began.  Even then, the government was saddled with the responsibility of determining the boundaries of the evacuation area, and thereafter to organise the evacuation.  This constituted a major imposition on the community as well as on government resources.
   
It was soon recognized that the factory's very rudimentary safety systems had been designed with little more than simple [[explosion]] prevention in mind.  Environmental protection had not been considered.  Nor had any consideration been given to setting up any type of warning system or health-protection protocols for the local community.  As a result, the local population was caught unaware when the accident happened and thus was unprepared to cope with the danger of an invisible poison.
 
<blockquote>In the context of such heightened tensions, Seveso became a microcosm where all the existing conflicts within society (political, institutional, religious, industrial) were reflected. However, within a relatively short time, such conflicts abated and the recovery of the community proceeded. For, in Seveso, the responsible party was known from the outset and soon offered reparation. Moreover, the eventual disappearance of the offending factory itself and the physical exportation of the toxic substances and polluted soil enabled the community to feel cleansed. The resolution of the emotional after-effects of the trauma, so necessary for the recovery of a community, was facilitated by these favourable circumstances."<ref>{{cite web|url=http://archive.unu.edu/unupress/unupbooks/uu21le/uu21le0a.htm|title=Conclusion: "Seveso" – A paradoxical symbol|publisher=United Nations University|author=B. De Marchi|author2=S. Funtowicz |author3=J. Ravetz }}</ref></blockquote>
 
[[Safety case|Industrial safety regulations]] were passed in the [[European Community]] in 1982 called the [[Directive 82/501/EC|Seveso Directive]],<ref>{{cite web|url=http://mahbsrv.jrc.it/downloads-pdf%5CSeveso1-LEG-EN.pdf|title=Original Seveso Directive 82/501/EEC ("Seveso I")|url-status=dead|archive-url=https://web.archive.org/web/20060510001118/http://mahbsrv.jrc.it/downloads-pdf/Seveso1-LEG-EN.pdf|archive-date=2006-05-10}}</ref> which imposed much stronger industrial regulations. The Seveso Directive was updated in 1996, 2008 and 2012 and is currently referred to as the [[Directive 2012/18/EU|Seveso III Directive]] (or [[COMAH Regulations]] in the United Kingdom).
 
[[Treatment of the soil]] in the affected areas is now considered complete since the dioxin levels are now below background. The entire site has been turned into a public park known as [[Seveso Oak Forest Park]]<!-- [[d:Q3895624]] -->.  This area is permanently off-limits to development. There are two artificial hills in the park; today, underneath these hills are the toxic remnants (including destroyed houses, tons of contaminated soil, and animal remains), all protected in a concrete sarcophagus.  Investigations into site conditions have confirmed that the sarcophagus life expectancy of 300 years is expected, appropriate, and required.{{citation needed|date=December 2019}}
 
Several studies have been completed on the health of the population of surrounding communities. While it has been established that people from Seveso exposed to TCDD are more susceptible to certain rare cancers, when all types of cancers are grouped into one category, no statistically significant increase has yet been reported in any specific cancer category. This indicates that more research is needed to determine the true long-term health effects on the affected population.
   
[[Epidemiological monitoring]] programmes were established as follows (with termination dates): abortions (1982); malformations (1982); tumours (1997); deaths (1997). Health monitoring of workers at ICMESA and on decontamination projects, and [[chloracne]] sufferers (1985)<ref name=":0">{{cite web|url=http://www.vn-agentorange.org/brochure.html|title=Vietnam Agent Orange Campaign – Background|url-status=dead|archive-url=https://web.archive.org/web/20060821134649/http://www.vn-agentorange.org/brochure.html|archive-date=2006-08-21}}</ref>

The documentary ''Gambit''<ref>Gambit (2005), German Wikipedia page.  https://de.wikipedia.org/wiki/Gambit_(2005), accessed (in German) on December 28, 2019.</ref><ref>Gambit (August 2005), Sabine Gisiger, Swiss Films Review.  https://www.swissfilms.ch/en/film_search/filmdetails/-/id_film/-1704568495</ref> is about Jörg Sambeth, the technical director of ICMESA, who was sentenced to five years in the first trial, had his sentence reduced to two years and was paroled on appeal.<ref>{{cite news|url=http://www.taz.de/pt/2006/07/10/a0137.1/text.ges,1|title=Ich war absolut dumm|pages=4|language=de|newspaper=Die Tageszeitung: Taz|date=2006-07-10}}</ref>

==See also==
* [[Environmental inequality in Europe]]
*''[[Inochi No Chikyuu: Dioxin No Natsu]]'' (a 2001 film about the incident)
*"Suffocation," the fifth track on the dystopian concept album, ''[[See You Later]]'', by [[Vangelis]], is inspired by the Seveso disaster and features an emergency announcement in Italian to take shelter and a dialog between a man and woman set during the unfolding of the disaster.<ref>{{Cite web|url=https://songmeanings.com/songs/view/3530822107858976964/|title=Original Italian lyrics with English translation|date=June 2019|website=Song Meanings}}</ref>
*"Seveso Directive", one of three [[Directive (European Union)|European Union Directives]] to improve the safety of sites containing large quantities of dangerous substances:
**[[Directive 82/501/EC]], also known as the "Seveso Directive"
**[[Directive 96/82/EC]], also known as the "Seveso II Directive"
**[[Directive 2012/18/EU]], also known as the "Seveso III Directive"

==References==
{{Reflist|30em}}

==Further reading==
*{{cite book|last=Fuller|first=John G.|title=Poison That Fell from the Sky|location=New York|publisher=Berkley Books|year=1979|isbn=0-425-04013-5}}
*{{cite book|last=Robbe|first=Federico|title=Seveso 1976. Oltre la diossina|location=Castel Bolognese|publisher=Itaca Books|year=2016|isbn=978-88-526-0486-7}}

==External links==
* Loss Prevention Bulletin [http://unified.icheme.org/~/media/Documents/icheme/Resources/LPB/LPB%20samples/SevesoDisasterAppraisal.ashx The Seveso Disaster: An appraisal of its causes and circumstances],{{dead link|date=December 2017 |bot=InternetArchiveBot |fix-attempted=yes }} Marshallvagri, V.C., LPB Issue 104, April 1992, [[IChemE]], UK.
* National Pollutant Inventory – [https://web.archive.org/web/20060513063928/http://npi.gov.au/database/substance-info/profiles/73.html Dioxin Fact Sheet]
* [http://www.getipm.com/articles/seveso-italy.htm Dioxin: Seveso disaster testament to effects of dioxin], article by Mick Corliss,  May 6, 1999.
* [http://www.hse.gov.uk/comah/sragtech/caseseveso76.htm Icmesa chemical company, Seveso, Italy. July 9, 1976] British Health & Safety Executive COMAH information page on the Seveso Disaster.
* [https://www.who.int/entity/ipcs/publications/en/exe-sum-final.pdf Assessment of the Health Risks of Dioxins], a 1998 report by the [[World Health Organization]].
* [https://web.archive.org/web/20060908073509/http://www.roche.com/home/company/com_hist/com_hist_1965.htm Roche – 1965–1978] [https://web.archive.org/web/20061231143828/http://www.roche.com/com_his_sev-e.pdf pdf] History timeline at the homepage of Hoffmann-LaRoche.
* {{Skeptoid|id=4921|number=921|title=Reconsidering the Seveso Dioxin Disaster.|date=January 30, 2024}}

{{Toxicology}}

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[[Category:Chemical disasters]]
[[Category:Chemical industry in Italy]]
[[Category:1976 industrial disasters]]
[[Category:1976 in Italy]]
[[Category:Environmental disasters in Europe]]
[[Category:Health disasters in Italy]]
[[Category:Corporate crime]]
[[Category:1976 health disasters]]
[[Category:1976 in the environment]]
[[Category:Waste disposal incidents]]
[[Category:July 1976 in Europe]]
[[Category:1970s disasters in Italy]]