View source for U.S. Route 49

{{short description|Highway in the United States}}
{{Use American English|date=April 2025}}
{{Use mdy dates|date=September 2019}}
{{Infobox road
| country = USA
| type = US
| route = 49
| map = {{maplink-road|from=U.S. Route 49.map}}
| map_custom = yes
| map_notes = US&nbsp;49 highlighted in red
| length_mi = 516
| length_ref = {{citation needed|date=February 2018}}
| length_round = 0
| established = 1926{{citation needed|date=February 2018}}
| direction_a = South
| direction_b = North
| section1 = Southern section
| terminus_a1 = {{Jct|state=MS|US|90}} at [[Gulfport, Mississippi|Gulfport, MS]]
| junction1 = 
*{{Jct|state=MS|I|10}} at [[Gulfport, Mississippi|Gulfport, MS]]
*{{Jct|state=MS|I|59}} at [[Hattiesburg, Mississippi|Hattiesburg, MS]]
*{{Jct|state=MS|I|20|I|55}} at [[Jackson, Mississippi|Jackson, MS]]
| terminus_b1 = {{Jct|state=MS|US|49E|US|49W}} at [[Yazoo City, Mississippi|Yazoo City, MS]]
| section2 = Northern section
| terminus_a2 = {{Jct|state=MS|US|49E|US|49W}} at [[Tutwiler, Mississippi|Tutwiler, MS]]
| junction2 = 
*{{Jct|state=MS|US|61}} at [[Clarksdale, Mississippi|Clarksdale, MS]]
*{{Jct|state=AR|I|40|US|63}} at [[Brinkley, Arkansas|Brinkley, AR]]
*{{Jct|state=AR|I|555|US|63}} at [[Jonesboro, Arkansas|Jonesboro, AR]]
| terminus_b2 = {{jct|state=AR|US|62|AR|1|AR|139}} at [[Piggott, Arkansas|Piggott, AR]]
| states = [[Mississippi]], [[Arkansas]]
| system1 = {{infobox road/browselinks/USA|state=MS}}
| system2 = {{infobox road/browselinks/USA|state=AR}}
| browse = {{Us browse|previous_type=US|previous_route=48|next_type=US|next_route=50|route=[[List of United States Numbered Highways|US]]}}{{ms browse|previous_type=MS|previous_route=48|route=MS|next_type=US|next_route=49E}}{{ar browse|previous_type=I|previous_route=49|route=AR|next_type=AR|next_route=50}}
| counties = '''MS:''' [[Harrison County, Mississippi|Harrison]], [[Stone County, Mississippi|Stone]], [[Forrest County, Mississippi|Forrest]], [[Covington County, Mississippi|Covington]], [[Simpson County, Mississippi|Simpson]], [[Rankin County, Mississippi|Rankin]], [[Hinds County, Mississippi|Hinds]], [[Madison County, Mississippi|Madison]], [[Yazoo County, Mississippi|Yazoo]]; [[Tallahatchie County, Mississippi|Tallahatchie]], [[Coahoma County, Mississippi|Coahoma]] <br />'''AR:''' [[Phillips County, Arkansas|Phillips]], [[Monroe County, Arkansas|Monroe]], [[Woodruff County, Arkansas|Woodruff]], [[Cross County, Arkansas|Cross]], [[Poinsett County, Arkansas|Poinsett]], [[Craighead County, Arkansas|Craighead]], [[Greene County, Arkansas|Greene]], [[Clay County, Arkansas|Clay]]
}}
'''U.S. Route 49''' ('''US 49''') is a north&ndash;south [[United States Numbered Highways|United States highway]]. The highway's northern terminus is in [[Piggott, Arkansas]], at an intersection with [[U.S. Route 62 in Arkansas|U.S. Route 62]] (US 62).  Its southern terminus is in [[Gulfport, Mississippi]], at an intersection with [[U.S. Route 90|US 90]]. US 49 is approximately 516&nbsp;miles (830&nbsp;km) in length.

It was at the junction of US 49 and [[U.S. Route 61]] that [[blues]] singer [[Robert Johnson (musician)|Robert Johnson]] is said to have sold his soul to the [[Devil]].  The highway is also the subject of songs by  Big Joe Williams and [[Howlin' Wolf]] (Chester Arthur Burnett).

==Route description==
{{lengths table|length_ref=<ref name="AASHTO lengths">{{cite web|publisher=[[American Association of State Highway and Transportation Officials]]|title=U.S. Route Number Database|url=http://nchrp20-7-228.com/USRoute.aspx|edition=Dec 2009 |archive-url=https://web.archive.org/web/20100630161420/http://nchrp20-7-228.com/USRoute.aspx |archive-date=June 30, 2010 |url-status=dead |access-date=February 12, 2022}}</ref>}}
|-
|MS
|{{convert|334|mi|km|disp=table}}
|-
|AR
|{{convert|182|km|disp=table}}
|-
|'''Total'''
|{{convert|516|km|disp=table}}
|}
===Mississippi===
US&nbsp;49 has historically been one of the most important highways in Mississippi. It was the state's first highway to see a significant rural segment four-laned.<ref>{{cite map |author = Traffic and Planning Division |url = http://www.gomdot.com/Divisions/IntermodalPlanning/Resources/Maps/pdf/StateHighwayMapsArchive/HWY%20Map%201960%20Front.pdf |title = Official Road Map |year = 1960 |location = Jackson |publisher = Mississippi State Highway Commission |archive-date=December 3, 2010 |archive-url=https://web.archive.org/web/20101203070957/http://www.gomdot.com/Divisions/IntermodalPlanning/Resources/Maps/pdf/StateHighwayMapsArchive/HWY%20Map%201960%20Front.pdf |url-status=dead |access-date=February 12, 2022}}</ref> Today, it is the only four-laned route directly connecting [[Jackson, Mississippi|Jackson]], the state's capital and largest city, to the [[Mississippi Gulf Coast]].<ref>{{cite map |author = Planning Division |year = 2009 |url=http://www.gomdot.com/Divisions/IntermodalPlanning/Resources/Maps/pdf/StateHighwayMaps/MS_map.pdf |title=Official Highway Map of Mississippi |scale = c. 1:760,320 |location = Jackson |publisher = Mississippi Department of Transportation |archive-date=November 23, 2009 |archive-url=https://web.archive.org/web/20091123060550/http://www.gomdot.com/Divisions/IntermodalPlanning/Resources/Maps/pdf/StateHighwayMaps/MS_map.pdf |url-status=dead |access-date=February 12, 2022}}</ref> Some urban segments along this portion of the route maintain three or more traffic lanes in each direction. US&nbsp;49 serves as a primary hurricane evacuation route for Gulf Coast residents.<ref>{{cite map |author = Planning Division |date = n.d. |url=http://www.gomdot.com/Home/EmergencyPreparedness/pdf/Hurricane%20Evacuation%20Map_11.pdf |title= Mississippi Hurricane Evacuation Map |scale = c. 1:760,320 |location = Jackson |publisher = Mississippi Department of Transportation  |archive-date=August 15, 2011 |archive-url=https://web.archive.org/web/20110815042707/http://www.gomdot.com/Home/EmergencyPreparedness/pdf/Hurricane%20Evacuation%20Map_11.pdf |url-status=dead |access-date=February 12, 2022}}</ref>

[[File:Southern terminus of US 49 at US 90.jpg|thumb|left|Southern terminus of US 49 at US 90 in Gulfport]]
US 49 begins near the Port of [[Gulfport, Mississippi]] at a junction with [[U.S. Route 90|US&nbsp;90]]. It provides a major connection between the port, casinos, beaches and downtown with [[Interstate 10|I-10]] (exits 34A-B), where it has its first major junction being a full service [[cloverleaf interchange]] on the city's north end. The crossing of these two roads is officially recognized by the state of Mississippi as the Castilgia Interchange.<ref>{{cite web|url=https://law.justia.com/codes/mississippi/2013/title-65/chapter-3/special-designations-of-portions-of-highway-system-and-bridges/section-65-3-71.17/|title=2013 Mississippi Code :: Title 65 - HIGHWAYS, BRIDGES AND FERRIES :: Chapter 3 - STATE HIGHWAY SYSTEM :: SPECIAL DESIGNATIONS OF PORTIONS OF HIGHWAY SYSTEM AND BRIDGES :: § 65-3-71.17 - "Castiglia Interchange" designated |archive-url=https://web.archive.org/web/20190608164047/https://law.justia.com/codes/mississippi/2013/title-65/chapter-3/special-designations-of-portions-of-highway-system-and-bridges/section-65-3-71.17/ |archive-date=June 8, 2019 |url-status=live |access-date=February 12, 2022}}</ref> North of I-10, US 49 passes through suburban areas and enters [[De Soto National Forest]]. Various state highway interchanges and junctions are encountered before the route passes near [[Camp Shelby]], then through an interchange with [[U.S. Route 98|US&nbsp;98]] just south of [[Hattiesburg, Mississippi|Hattiesburg]]. At this point, travelers have an option of continuing on US&nbsp;49 through Hattiesburg or using the [[Interstate 59|I-59]]/US&nbsp;98 bypass which reconnects with US&nbsp;49 in the northern part of the city. Continuing on US&nbsp;49 brings one to a cloverleaf interchange at [[U.S. Route 11|US&nbsp;11]], one of very few in the South to lack merging lanes between loop ramps, thus exacerbating the [[traffic weaving|weaving]] patterns which plague many cloverleaf interchanges.

US 49 passes Hattiesburg's primary medical facility, [[Forrest General Hospital]], and the campus of the [[University of Southern Mississippi]] before arriving at another, more standard cloverleaf interchange with I-59. Those who used the aforementioned bypass, wishing to reconnect with US&nbsp;49 North to the state capital, must use exit 67B. It is also at I-59, where [[Mississippi Highway 42]] (MS 42) runs with US&nbsp;49 for a short distance as suburban development is soon encountered as the road returns to rural environs. Eventually, MS 42 departs from the four-laned highway and branches off to the west toward smaller towns, starting with [[Sumrall, Mississippi|Sumrall]]. Interchanges between Hattiesburg and Jackson provide access to various state highways, and one at Collins provides access to [[U.S. Route 84|US&nbsp;84]].

[[File:Highway 49W north of Yazoo City, MS.jpg|thumb|left|US 49W passing through the Mississippi Delta north of Yazoo City]]
At Jackson, US&nbsp;49 upgrades to [[Interstate Highway standards]] before joining [[Interstate 20|I-20]] using a two-lane flyover. About a mile later, I-20/US&nbsp;49 merges with [[Interstate 55|I-55]] at a [[stack interchange]]. I-20/I-55/US&nbsp;49 crosses the Pearl River into Hinds County and bypasses Downtown Jackson, where I-55 departs to the south. US 49/I-20 continue west until US 49 ends its run with I-20 and joins [[Interstate 220 (Mississippi)|I-220]] before turning northwest to [[Yazoo City, Mississippi|Yazoo City]]. A split in the highway, rare in the [[United States Numbered Highway System|U.S. Highway System]], begins here; both routes head into the Mississippi Delta, [[U.S. Route 49W|US 49W]] serving the towns of [[Belzoni, Mississippi|Belzoni]] and [[Indianola, Mississippi|Indianola]], where it junctions with [[U.S. Route 82|US&nbsp;82]] and its four-lane segment ends, while two-laned [[U.S. Route 49E|US&nbsp;49E]] serves [[Tchula, Mississippi|Tchula]] before encountering US 82 at [[Greenwood, Mississippi|Greenwood]]. Both routes continue north from US&nbsp;82 and are linked again at [[Tutwiler, Mississippi|Tutwiler]]. Continuing northwest, the highway passes through an interchange with [[U.S. Route 61|US&nbsp;61]] as it enters [[Clarksdale, Mississippi|Clarksdale]]. It is at Clarksdale that US&nbsp;49 encounters "The Crossroads", the legendary junction with State Street (an old alignment of US 61) where the great blues musician [[Robert Johnson]] is reputed to have sold his soul to the devil.<ref>{{cite web |url=https://www.latimes.com/archives/la-xpm-2011-may-01-la-ca-robert-johnson-20110501-story.html |title=At the crossroads as Robert Johnson centennial nears |website=[[Los Angeles Times]] |archive-date=May 3, 2011 |archive-url=https://web.archive.org/web/20110503200052/http://articles.latimes.com/2011/may/01/entertainment/la-ca-robert-johnson-20110501 |url-status=live |access-date=February 12, 2022}}</ref>

From Clarksdale, US&nbsp;49 continues north and crosses the [[Mississippi River]] using the [[Helena Bridge]] where it enters Arkansas near the town of [[Helena, Arkansas|Helena]].

[[File:ClarksdaleMS Crossroads.jpg|right|thumb|The legendary "Crossroads" at [[Clarksdale, Mississippi|Clarksdale]], the inspiration for the song "[[Cross Road Blues]]"]]
[[File:Highway49TutwilerMS.jpg|thumb|Split of US&nbsp;49 in Tutwiler]]

In May 2005 portions of extant US&nbsp;49E were renamed the "Emmett Till Memorial Highway".<ref>{{cite web |url=http://www.glendorams.com/cultural-heritage-tourism/emmett-till-museum/ |title=Emmett Till Museum |archive-date=July 11, 2011 |archive-url=https://web.archive.org/web/20110711101109/http://www.glendorams.com/cultural-heritage-tourism/emmett-till-museum/ |url-status=dead |access-date=February 12, 2022}}</ref>

The Mississippi section of US 49 and the routes of US 49E and US 49W are defined at Mississippi Code Annotated § 65-3-3.

===Arkansas===
US 49 enters Arkansas near [[Helena-West Helena, Arkansas|Helena-West Helena]] in [[Phillips County, Arkansas|Phillips County]]. [[U.S. Route 49 Business (Helena-West Helena, Arkansas)|US 49 Business]] runs around the north part of the city, with the main route meeting [[Arkansas Highway 242|AR 242]] in the southern portion. US 49 continues west to Walnut Corner where the route meets [[Arkansas Highway 1|AR 1]] (and briefly [[Arkansas Highway 316|AR 316]]). The US 49/AR 1 concurrency ends in [[Marvell, Arkansas|Marvell]] and US 49 enters [[Monroe County, Arkansas|Monroe County]].

Upon entering Monroe County, US 49 turns north to begin a concurrency with [[Arkansas Highway 39|AR 39]]. US 49 also crosses [[U.S. Route 79|US 79]] before meeting [[U.S. Route 70 in Arkansas|US 70]] near [[Brinkley, Arkansas|Brinkley]]. The route crosses [[Interstate 40]] north of Brinkley prior to entering [[Woodruff County, Arkansas|Woodruff County]]. US 49 runs northeast through rural Woodruff County, not crossing of concurring with any important routes before crossing into [[Cross County, Arkansas|Cross County]].

The route meets [[U.S. Route 64|US 64]] in [[Fair Oaks, Arkansas|Fair Oaks]] and meets [[Arkansas Highway 42|AR 42]] in southern [[Hickory Ridge, Arkansas|Hickory Ridge]]. It then enters [[Poinsett County, Arkansas|Poinsett County]], concurring with [[Arkansas Highway 214|AR 214]] from [[Fisher, Arkansas|Fisher]] until [[Waldenburg, Arkansas|Waldenburg]]. The route  crosses [[Arkansas Highway 14|AR 14]] in Waldenburg.

US 49 runs along south [[Jonesboro, Arkansas|Jonesboro]], with [[U.S. Route 49 Business (Jonesboro, Arkansas)|US 49 Business]] formerly running into town. US 49 concurs with [[U.S. Route 63|US 63]] until again joining AR 1. The two routes angle north through downtown Jonesboro, crossing [[U.S. Route 63 Business (Jonesboro, Arkansas)|US 63 Business]] and passing by [[Centennial Bank Stadium|ASU Stadium]] before leaving town. US 49/AR 1 pass around [[Brookland, Arkansas|Brookland]], with [[U.S. Route 49 Business (Brookland, Arkansas)|US 49 Business]] serving the community.

Entering [[Greene County, Arkansas|Greene County]], US 49/AR 1 intersects [[U.S. Route 412|US 412]] and briefly meets [[Arkansas Highway 358|AR 358]] before entering [[Paragould, Arkansas|Paragould]]. The routes cross [[U.S. Route 412B (Paragould, Arkansas)|US 412B]] near [[Kirk Field]] in Paragould, also meeting [[Arkansas Highway 135|AR 135]] north of town. [[U.S. Route 49 Business (Paragould, Arkansas)|US 49B]] also rejoins US 49/AR 1 north of Paragould.

Continuing northeast through rural Greene County, US 49/AR 1 meet [[Arkansas Highway 34|AR 34]] in [[Marmaduke, Arkansas|Marmaduke]] and [[Arkansas Highway 90|AR 90]] in [[Rector, Arkansas|Rector]]. The route turns north to [[Piggott, Arkansas|Piggott]] at Hargrave Corner, terminating at [[U.S. Route 62|US 62]]/[[Arkansas Highway 139|AR 139]]. The Arkansas portion of US 49 is mainly two-lane undivided.

==History==
One of the original US highways, US&nbsp;49 was extended north from [[Clarksdale, Mississippi]] to [[U.S. Route 70 in Arkansas|US&nbsp;70]] in [[Brinkley, Arkansas]] via [[U.S. Route 61]] and [[Mississippi Highway 6|Highway&nbsp;6]] in 1963.<ref>{{cite web |url=http://www.arkansashighways.com/minute_orders/Mo53-69.pdf |title= Minutes of the Meeting |date= March 20, 1963 |publisher=Arkansas State Highway Commission |pages=903–904 |archive-url=https://web.archive.org/web/20100921001026/http://www.arkansashighways.com/minute_orders/Mo53-69.pdf |archive-date=September 21, 2010 |url-status=dead |access-date=February 12, 2022}}</ref> US&nbsp;49 was again extended north in 1978, replacing [[Arkansas Highway 39|Highway&nbsp;39]] between Brinkley and [[Jonesboro, Arkansas|Jonesboro]].<ref name="Mo70-79.pdf">{{cite web |url=http://www.arkansashighways.com/minute_orders/Mo70-79.pdf |title=Minutes of the Meeting |date=April 26, 1978 |publisher=Arkansas State Highway Commission |archive-url=https://web.archive.org/web/20100921003202/http://www.arkansashighways.com/minute_orders/Mo70-79.pdf |archive-date=September 21, 2010 |url-status=dead |access-date=February 12, 2022}}</ref>{{rp|269–270}} [[Arkansas Highway 1|Highway&nbsp;1]] between Jonesboro and [[Piggott, Arkansas|Piggott]] was redesignated as US&nbsp;49 in 1979.<ref name="Mo70-79.pdf" />{{rp|66}}

It is notable that for several years during the 1930s, a second split route existed on US&nbsp;49 in South Mississippi, similar to but shorter than the split that still exists in the Delta region.<ref>{{cite web |url=http://mdot.ms.gov/documents/planning/Maps/State%20Highway%20Maps%20Archive/HWY%20Map%201936%20Road%20Map%20of%20MS.pdf |title=Official Mississippi Highway Map of 1936 |archive-date=May 14, 2014 |archive-url=https://web.archive.org/web/20140514205532/http://mdot.ms.gov/documents/planning/Maps/State%20Highway%20Maps%20Archive/HWY%20Map%201936%20Road%20Map%20of%20MS.pdf |url-status=dead |access-date=February 12, 2022}}</ref> Between Brooklyn and Hattiesburg, travelers had the option of a {{convert|24|mi|km|adj=mid|-long}} direct route via US&nbsp;49W, or a somewhat shorter but broken route on US&nbsp;49E, serving the [[Forrest County Agricultural High School]] and the small community of [[McLaurin, Mississippi]].

==Gallery==
{{gallery|width=213|height=213
|File:Fair Oaks, AR 003.jpg|US 49 in [[Fair Oaks, Arkansas|Fair Oaks, AR]]
|File:Highway 49 north of Brinkley, AR.jpg|US 49 north of [[Brinkley, AR]]

|File:US 49 in Brinkley, AR.jpg|US 49 south of the US 70 junction in south Brinkley
|File:US 49 south of Louisiana Purchase State Park.jpg|US 49 south of Highway 362 junction near [[Louisiana Purchase State Park]]
|File:US 49 and Highway 1 in Marvell, AR.jpg|US 49 and Highway 1 concur in [[Marvell, AR]]
|File:US 49 in Helena-West Helena, AR.jpg|US 49 in [[Helena-West Helena, Arkansas|Helena-West Helena, AR]]
|File:US 49, US 61 and US 278 in Mississippi.jpg|US 49 with U.S. Routes 61 and 278
}}

==Major intersections==
{{jcttop|exit|state_col=State|length_ref=<ref name="db">{{cite web |url=http://www.arkansashighways.com/planning_research/technical_services/databases/Road%20Log%20Database.zip |title=Arkansas Road Log Database |author=Planning and Research Division |year=2010 |publisher=Arkansas State Highway and Transportation Department |format=ZIP |archive-url=https://web.archive.org/web/20110623010127/http://arkansashighways.com/planning_research/technical_services/databases/Road%20Log%20Database.zip |archive-date=June 23, 2011 |url-status=dead |access-date=February 12, 2022}}</ref><ref>{{cite map |author1=Arkansas State Highway and Transportation Department |author1-link=Arkansas Department of Transportation |year=2015 |title=General Highway Map: Greene County, Arkansas |scale=[1:62,500] |url=https://www.arkansashighways.com/maps/Counties/County%20PDFs/GreeneCounty.pdf |archive-url=https://web.archive.org/web/20100922113839/https://www.arkansashighways.com/maps/Counties/County%20PDFs/GreeneCounty.pdf |archive-date=September 22, 2010 |url-status=dead |access-date=February 12, 2022}}</ref>}}
{{MSint|exit
|sspan=68
|county=Harrison|cspan=4
|location=Gulfport|lspan=3
|mile=0.00
|exit=
|espan=38
|road={{jct|state=MS|US|90|city1=Biloxi|city2=Long Beach|location3=[[Ship Island Ferry]]}}
|notes=Southern terminus}}
{{MSint
|mile=4.4
|mile2=4.9
|exit=
|road={{jct|state=MS|I|10|location1=[[New Orleans, LA|New Orleans]]|location2=[[Biloxi, Mississippi|Biloxi]]|location3=[[Mobile, AL|Mobile]]}}
|notes=Exits 34A-B on I-10
}}
{{MSint
|mile=9.4
|road={{jct|state=MS|MS|53|dir1=north|city1=Poplarville|location2=Lyman Fish Hatchery}}
}}
{{MSint
|location=none
|mile=20.0
|mile2=20.6
|road={{jct|state=MS|MS|67|dir1=south|city1=D'Iberville|city2=Biloxi}}
|notes=Interchange
}}
{{MSint
|county=Stone|cspan=3
|location=Wiggins, Stone County|lspan=3
|mile=32.9
|road={{jct|state=MS|MS|149|dir1=north|to2=to|MS|29|city1=Downtown Wiggins|city2=South Wiggins|location3=[[Flint Creek Water Park]]}}
}}
{{MSint
|mile=34.2
|mile2=34.6
|road={{jct|state=MS|MS|26|city1=Poplarville|city2=Lucedale}}
|notes=Interchange
}}
{{MSint
|mile=36.7
|road={{jct|state=MS|MS|149|dir1=south|to2=to|MS|29|city1=Downtown Wiggins|location2=[[Flint Creek Water Park]]}}
}}
{{MSint
|county=Forrest|cspan=9
|mile=41.6
|location=none
|road={{jct|state=MS|MS|13|dir1=north|city1=Lumberton}}
}}
{{MSint
|location=none
|mile=54.6
|road={{jct|state=MS|road|S Lake Drive|location1=[[Paul B. Johnson State Park]]}}
|notes=Access road into park
}}
{{MSint
|location=Hattiesburg|lspan=6
|mile=62.3
|mile2=62.8
|road={{jct|state=MS|US|98|to2=to|I|59|city1=Columbia|city2=Laurel|city3=Lucedale|location4=[[Mobile, AL|Mobile]]}}
|notes=Interchange
}}
{{MSint
|mile=65.1
|road=Edwards Street (MS 969 north)
}}
{{MSint
|mile=67.5
|mile2=67.9
|road={{jct|state=MS|US|11|name1=Broadway Drive|city1=Purvis}}
|notes=Interchange
}}
{{MSint
|mile=69.1
|road={{jct|state=MS|MS|198|dir1=west|name1=Hardy Street|to2=to|I|59<!--southbound only; northbound it's straight-->|US|98|city1=Columbia}}
}}
{{MSint
|mile=70.7
|road=Old Highway 42 - [[Petal, MS|Petal]]
|notes=Former [[MS 42]] east
}}
{{MSint
|type=concur
|mile=71.6
|mile2=72.0
|road={{jct|state=MS|I|59|MS|42|dir2=east|location1=[[New Orleans, LA|New Orleans]]|city2=Gulf Coast|city3=Laurel|extra=airport|location4=[[Hattiesburg-Laurel Regional Airport|Airport]]}}
|notes=Southern end of MS 42 concurrency; exit 67 on I-59
}}
{{MSint
|type=concur
|location=none
|mile=77.5
|road={{jct|state=MS|MS|42|dir1=west|city1=Sumrall|city2=Prentiss}}
|notes=Northern end of MS 42 concurrency
}}
{{MSint
|county=Covington|cspan=8
|location=none
|mile=84.2
|road={{jct|state=MS|MS|598|nolink1=yes|dir1=east|city1=Sanford}}
}}
{{MSint
|location=Seminary<!--per green signs-->|lspan=2<!--probably-->
|mile=88.9
|road={{jct|state=MS|MS|589|dir1=south|city1=Sumrall}}
}}
{{MSint
|mile=89.1
|road={{jct|state=MS|MS|590|dir1=east|city1=Seminary}}
}}
{{MSint
|location=Collins|lspan=2
|mile=95.1
|mile2=95.5
|road={{jct|state=MS|MS|184|city1=Downtown Collins}}
|notes=Interchange
}}
{{MSint
|mile=96.4
|mile2=96.7
|road={{jct|state=MS|US|84|city1=Prentiss|city2=Laurel}}
|notes=Interchange
}}
{{MSint
|location=none
|mile=104.2
|road={{jct|state=MS|MS|149|dir1=north}}
}}
{{MSint
|location=Mount Olive|lspan=2
|mile=104.7
|road={{jct|state=MS|MS|35|city1=Bassfield|city2=Columbia|city3=Mount Olive|city4=Mize}}
}}
{{MSint
|mile=106.6
|road={{jct|state=MS|MS|149|dir1=south|city1=Mount Olive}}
}}
{{MSint
|county=Simpson|cspan=10
|location=Magee|lspan=5
|mile=113.4
|road={{jct|state=MS|MS|149|dir1=north}}
}}
{{MSint
|type=concur
|mile=114.1
|road={{jct|state=MS|MS|28|dir1=east|city1=Mize|city2=Laurel}}
|notes=Southern end of MS 28 concurrency
}}
{{MSint
|type=concur
|mile=114.2
|road={{jct|state=MS|MS|541|dir1=north|city1=Downtown Magee}}
|notes=Southern end of MS 541 concurrency
}}
{{MSint
|type=concur
|mile=114.6
|road={{jct|state=MS|MS|28|dir1=west|MS|541|dir2=south|city1=Georgetown|city2=Hazlehurst}}
|notes=Northern end of MS 28/MS 541 concurrency
}}
{{MSint
|mile=117.0
|road={{jct|state=MS|MS|149|to2=to|MS|545|nolink2=yes|location1=Boswell Regional Center ([[Mississippi Department of Mental Health|Department of Mental Health]])}}|notes=Interchange
}}
{{MSint
|location=none
|mile=119.3
|road={{jct|state=MS|MS|149|dir1=south|city1=Sanatorium}}
|notes=}}
{{MSint
|location=Mendenhall|lspan=3
|mile=123.8
|road={{jct|state=MS|MS|149|dir1=north}}
|notes=}}
{{MSint
|mile=124.1
|road={{jct|state=MS|MS|540}}
}}
{{MSint
|mile=126.1
|mile2=126.4
|road={{jct|state=MS|MS|13|city1=Mendenhall|city2=Prentiss|city3=Puckett}}
|notes=Interchange
}}
{{MSint
|location=none
|mile=134.2
|road={{jct|state=MS|MS|149|dir1=south}}
}}
{{MSint
|county=Rankin|cspan=5
|location=Florence
|mile=145.5
|road={{jct|state=MS|MS|469|city1=Downtown Florence|city2=Brandon}}
}}
{{MSint
|type=incomplete
|location=Richland|lspan=3
|mile=151.8
|road=Old Highway 49
|notes=Proposed [[MS 149]] north; northbound exit and southbound entrance
}}
{{MSint
|mile=152.6
|mile2=152.9
|mspan=2
|type=incomplete
|road=East Frontage Road
|notes=Interchange; northbound exit and entrance
}}
{{MSint
|mile=none
|type=incomplete
|road=West Frontage Road
|notes=Interchange; southbound exit and entrance
}}
{{MSint|exit
|type=concur
|location1=Richland
|location2=Pearl
|mile=153.8
|exit=47
|road={{jct|state=MS|I|20|I|55|dir1=east|dir2=north|city1=Meridian|city2=Grenada|to3=to|US|80|city3=Flowood}}
|notes=Southern end of I-20/I-55 concurrency; exit 94 on I-55
}}
{{MSint|exit
|type=incomplete
|county=Hinds|cspan=11
|location=Jackson|lspan=11
|mile=154.3
|exit=45B
|road={{jct|state=MS|US|51|dir1=north}}
|notes=Southbound exit is exit 45
}}
{{MSint|exit
|type=incomplete
|mile=154.6
|exit=45A
|road=Gallatin Street
|notes=Southbound exit is exit 45
}}
{{MSint|exit
|type=concur
|mile=155.3
|exit=44
|road={{jct|state=MS|I|55|dir1=south|to2=to|US|51|dir2=south|city1=McComb}}, [[New Orleans, Louisiana|New Orleans]]
|notes=Northern end of I-55 concurrency
}}
{{MSint|exit
|mile=155.6
|exit=43
|road=Terry Road / University Boulevard
|notes=Signed as exits 43A (south) and 43B (north)
}}
{{MSint|exit
|mile=156.4
|exit=42
|road=Ellis Avenue
|notes=Signed as exits 42A (south) and 42B (north)
}}
{{MSint|exit
|type=concur
|mile=159.7
|exit=41
|road={{jct|state=MS|I|20|dir1=west|city1=Vicksburg}}<br>{{jct|state=MS|I|220|dir1=begins}}
|notes=Northern end of I-20 concurrency; southern terminus of I-220
}}
{{MSint|exit
|type=
|mile=160
|exit=1
|road={{jct|state=MS|US|80|MS|18|city1=Clinton|city2=Pearl}}
|notes=Signed as exits 1A (east) and 1B (west)
}}
{{MSint|exit
|type=
|mile=161.3
|exit=2
|road=Clinton Boulevard / Capitol Street
|notes=Signed as exits 2A (Capitol Street) and 2B (Clinton Blvd.) northbound
}}
{{MSint|exit
|type=
|mile=162.7
|exit=3
|road=Industrial Drive
|notes=[[Diamond interchange]]
}}
{{MSint|exit
|type=concur
|mile=164.7
|exit=5
|road={{jct|state=MS|I|220|dir1=north|road|Medgar Evers Boulevard}}
|notes=Signed as exits 5A (Medgar Evers) and 5B (I-220); northern end of I-220 concurrency
}}
{{MSint|exit
|mile=167.1
|mile2=167.3
|espan=8
|road={{jct|state=MS|NTP}}
|notes=Interchange
}}
{{MSint
|county=Madison|cspan=1
|location=Flora|lspan=1
|mile=179.0
|road={{jct|state=MS|MS|22|city1=Edwards|city2=Flora|city3=Canton|location4=[[Mississippi Petrified Forest National Natural Landmark]]}}
}}
{{MSint
|county=Yazoo|cspan=6
|location=Bentonia|lspan=3
|mile=186.3
|road={{jct|state=MS|MS|830|dir1=west|city1=Bentonia}}
|notes=Eastern terminus of MS 830
}}
{{MSint
|mile=187.0
|road={{jct|state=MS|MS|433|city1=Satartia|city2=Bentonia}}
}}
{{MSint
|mile=187.7
|road={{jct|state=MS|MS|830|dir1=east|city1=Bentonia}}
|notes=Western terminus of MS 830
}}
{{MSint
|type=concur
|location=none
|mile=200.7
|road={{jct|state=MS|MS|16|dir1=east|city1=Benton|city2=Canton}}
|notes=Southern end of MS 16 concurrency
}}
{{MSint
|type=concur
|location=Yazoo City|lspan=2
|mile=201.0
|road={{jct|state=MS|MS|16|dir1=west|MS|149|dir2=north|city1=Downtown Yazoo City}}
|notes=Northern end of MS 16 concurrency
}}
{{MSint|type=trans
|mile=204.2
|road={{jct|state=MS|US|49E|dir1=north|name1=Jerry Clower Boulevard|US|49W|dir2=north|to3=to|MS|3|dir3=south|name2=Haley Barbour Parkway|city1=Greenwood|city2=Indianola|city3=Vicksburg}}
|notes=Interchange; US 49 north splits into US&nbsp;49E and US 49W
}}
{{jctgap|text=See [[U.S. Route 49E#Major intersections|US 49E]] and [[U.S. Route 49W#Major intersections|US 49W]]}}
{{MSint|exit
|type=trans
|county=Tallahatchie|cspan=3
|location=Tutwiler|lspan=3
|mile=0.0
|exit=
|road={{jct|state=MS|US|49W|dir1=south|name1={{jct|state=MS|MS|3|dir1=south|noshield=yes}}|US|49E|dir2=south|city1=Indianola|city2=Greenwood}}
|notes=Southern end of MS 3 concurrency; US&nbsp;49 south splits into US 49E and US 49W
}}
{{MSint|exit
|type=concur
|mile=0.4
|exit=
|road={{jct|state=MS|MS|3|dir1=north|city1=Marks|city2=Lambert}}
|notes=Northern end of MS 3 concurrency
}}
{{MSint|exit
|mile=0.6
|exit=
|espan=8
|road={{jct|state=MS|MS|726|dir1=west}}
}}
{{MSint
|type=concur
|county=Coahoma|cspan=7
|location=Clarksdale|lspan=3
|mile=12.5
|road={{jct|state=MS|MS|322|dir1=east}}
|notes=Southern end of MS 322 concurrency
}}
{{MSint
|type=concur
|mile=13.0
|road={{jct|state=MS|US|61|dir1=south|US|278|dir2=west|MS|322|dir3=west|name4=[[MS 149]] north<!--not signed here-->
|city1=Clarksdale|city2=Cleveland|city3=Greenville|location4=[[Delta Blues Museum]]}}
|notes=Interchange; northern end of MS 322 concurrency; southern end of US 61/US 278 concurrency
}}
{{MSint
|type=concur
|mile=116.3
|mile2=117.0
|road={{jct|state=MS|US|278|dir1=east|MS|6|city1=Clarksdale|city2=Batesville}}
|notes=Northern end of US 278 concurrency
}}
{{MSint
|location=none
|mile=118.0
|road={{jct|state=MS|MS|161|dir1=south|city1=Lyon|city2=North Clarksdale}}
}}
{{MSint
|location=none
|mile=27.3
|road=Friars Point-Highway 61 / Highway 61-Jonestown<!--these are the street names--> – [[Friars Point, MS|Friars Point]], [[Moon Lake, MS|Moon Lake]]
|notes=Proposed [[Mississippi Highway 316|MS 316]]
}}
{{MSint
|type=concur
|location=none
|mile=31.8
|road={{jct|state=MS|US|61|dir1=north|MS|315|dir2=south|name2=Lula-Rich|city1=Tunica|location2=[[Memphis, TN|Memphis]]<!--signed at the other end of the overlap-->|city3=Sledge|city4=Sardis|road|[[Great River Road]]<!--unsigned here-->}}
|notes=North end of US 61 overlap; south end of Great River Road overlap
}}
{{MSint
|location=none
|mile=37.9
|road={{jct|state=MS|MS|1|dir1=south|city1=Friars Point|location2=[[North Delta Museum]]}}
}}
{{jctbridge
|mile=40.9
|line=yes
|mile2=0.00
|bridge=[[Helena Bridge]]
|river=[[Mississippi River]]
|river_wide=yes
|notes=[[Mississippi]]–[[Arkansas]] state line
}}
{{ARint|exit
|sspan=61
|county=Phillips|cspan=12
|location=Helena-West Helena
|lspan=5
|mile=0.99
|exit=
|road={{jct|state=AR|US|49B|dab1=Helena-West Helena|dir1=north|name1=Biscoe Drive|location1=Business District}}
}}
{{ARint|exit
|mile=1.35
|exit=
|road={{jct|state=AR|AR|20|to2=to|AR|44|city1=Lakeview|city2=Elaine|location3=[[Helena Harbor|Harbor and Industrial Park]]}}
|notes=Former AR 49
}}
{{ARint|exit
|mile=3.98
|exit=
|espan=37
|road={{jct|state=AR|AR|242|to2=to|AR|185}}
}}
{{ARint
|mile=6.28
|road={{jct|state=AR|US|49B|dab1=Helena-West Helena|dir1=south|name1=North Sebastian Street|location1=Business District}}
}}
{{ARint
|mile=6.88
|road={{jct|state=AR|AR|185|dir1=north|location1=[[Thompson-Robbins Airport|Municipal Airport]]}}
}}
{{ARint
|location=Walnut Corner|ctdab=Phillips
|mile=12.48
|road={{jct|state=AR|AR|1|dir1=north|AR|85|dir2=south|city1=Barton|city2=Lake View}}
}}<!--no overlap signed-->
{{ARint
|location=Kindall
|mile=15.45
|road={{jct|state=AR|AR|316|dir1=north|city1=Rondo}}
}}<!--no overlap signed-->
{{ARint
|location=Poplar Grove
|mile=17.58
|road={{jct|state=AR|AR|316|dir1=south|city1=Trenton}}
}}
{{ARint
|location=Marvell
|lspan=2
|mile=20.62
|road={{jct|state=AR|AR|243|dir1=north}}
}}
{{ARint
|mile=21.52
|road={{jct|state=AR|AR|1|dir1=south|city1=DeWitt}}
}}
{{ARint
|location=none
|mile=27.56
|road={{jct|state=AR|AR|39|dir1=south|city1=Postelle|location2=[[Turner, Phillips County, Arkansas|Turner]]}}
}}
{{ARint
|location=none
|mile=29.67
|road={{jct|state=AR|AR|86|dir1=west|city1=Holly Grove}}
}}
{{ARint
|county=Monroe
|cspan=12
|location=none
|mile=33.56
|road={{jct|state=AR|AR|362|dir1=east<!--is the direction signed?-->|location1=[[Louisiana Purchase Historic State Park]]}}
}}
{{ARint
|location=none
|mile=35.60
|road={{jct|state=AR|AR|39|dir1=north|city1=Blackton}}
}}
{{ARint
|location=none
|mile=36.70
|road={{jct|state=AR|AR|366<!--is a direction signed?-->}}
}}
{{ARint
|location=none
|mile=38.67
|road={{jct|state=AR|US|79|city1=Clarendon|city2=Marianna|city3=Stuttgart|city4=Holly Grove}}
}}
{{ARint
|location=none
|mile=41.30
|road={{jct|state=AR|AR|39S|dab1=Monroe County|city1=Monroe|dir1=east}}
}}
{{ARint
|location=none
|mile=43.55
|road={{jct|state=AR|AR|39|dir1=south|AR|241|dir2=north|city1=Rich}}
}}
{{ARint
|location=none
|mile=50.67
|road={{jct|state=AR|AR|238S|dab1=Brinkley|dir1=west}}
}}
{{ARint
|type=concur
|location=Brinkley|lspan=5
|mile=51.80
|road={{jct|state=AR|US|70|dir1=west|city1=DeValls Bluff}}
|notes=South end of US 70 overlap
}}
{{ARint
|mile=52.55
|road={{jct|state=AR|AR|238|dir1=east|name1=West Sycamore Street}}
}}
{{ARint
|type=concur
|mile=53.39
|road={{jct|state=AR|US|70|dir1=east|name1=West Cypress Street}}
|notes=Northern end of US 70 concurrency
}}
{{ARint
|type=concur
|mile=54.97
|road={{jct|state=AR|I|40|US|63|dir2=south|city1=Little Rock|location2=[[Memphis, TN|Memphis]]}}
|notes=Southern end of US 63 concurrency; exit 216 on I-40
}}
{{ARint
|mile=56.13
|road={{jct|state=AR|AR|17|dir1=north|city1=Cotton Plant}}<!--is the overlap still signed at all?-->
}}
{{ARint
|county=Woodruff
|cspan=4
|location=none
|mile=62.47
|road={{jct|state=AR|AR|38|dir1=west|city1=Cotton Plant}}
}}
{{ARint
|location=Hunter
|mile=66.28
|road={{jct|state=AR|AR|306|dir1=east|to2=to|AR|78}}
}}
{{ARint
|location=none
|mile=71.61
|road={{jct|state=AR|AR|269|dir1=north|to2=to|AR|145}}
}}
{{ARint
|location=Penrose
|mile=76.23
|road={{jct|state=AR|AR|284|dir1=east|to2=to|AR|193}}
}}
{{ARint
|type=concur
|county=Cross|cspan=4
|location=Fair Oaks<!--maybe-->|lspan=2
|mile=80.26
|road={{jct|state=AR|US|64|dir1=west|city1=Bald Knob}}
|notes=Southern end of US 64 concurrency
}}
{{ARint
|type=concur
|mile=80.28
|road={{jct|state=AR|US|64|dir1=east|city1=Wynne}}
|notes=Northern end of US 64 concurrency
}}
{{ARint
|location=Tilton
|mile=84.88
|road={{jct|state=AR|AR|364|dir1=east|city1=Vanndale}}
}}
{{ARint
|location=Hickory Ridge
|mile=90.44
|road={{jct|state=AR|AR|42|to2=to|AR|37|city1=Cherry Valley}}
}}
{{ARint
|county=Poinsett
|cspan=4
|location=Fisher
|mile=96.67
|road={{jct|state=AR|AR|214|dir1=east|city1=White Hall}}
}}
{{ARint
|location=Waldenburg
|mile=102.74
|road={{jct|state=AR|AR|14|city1=Newport|city2=Harrisburg}}
}}
{{ARint
|location=none
|mile=104.9
|road={{jct|state=AR|AR<!--"marine fuel tax" shield-->|956-1|location1=[[Lake Hogue]] Public Fishing}}
}}
{{ARint
|location=none
|mile=109.34
|road={{jct|state=AR|AR|214|dir1=west|city1=Grubbs}}
}}
{{ARint
|county1=Poinsett
|county2=Craighead
|location=none
|mile=113.42
|road={{jct|state=AR|AR|158}}
}}
{{ARint
|type=concur
|county=Craighead|cspan=11
|location=Jonesboro|lspan=9
|mile=120.50
|road={{jct|state=AR|AR|226|dir1=west|US|78|dir2=west|to3=to|US|67}}
|notes=Southern end of US 78/AR 226 concurrency
}}
{{ARint
|type=concur
|mile=122.4
|road={{jct|state=AR|AR|226|dir1=east|name1=Woodsprings Road}}
|notes=Northern end of AR 226 concurrency
}}
{{ARint|exit
|type=concur
|mile=125.53
|exit=45
|road={{jct|state=AR|I|555|dir1=north|US|63|dir2=north|AR|18|dir3=west|name3=Southwest Drive|city1=Walnut Ridge|city2=Hoxie}}
|notes=Northern end of US 63 concurrency; southern end of I-555 concurrency
}}
{{ARint|exit
|mile=43.4
|exit=44
|road={{jct|state=AR|AR|1B|dab1=Jonesboro|name1=Harrisburg Road}}
|notes=
}}
{{ARint|exit
|type=concur
|mile=128.40
|exit=42
|road={{jct|state=AR|I|555|dir1=south|AR|1|dir2=south|US|78|dir3=east|name2=Stadium Boulevard|road|Caraway Road|location1=[[Memphis, TN|Memphis]]|city2=Harrisburg|city3=Blytheville}}
|notes=Northern end of I-555/US 78 concurrency; southern end of AR 1 concurrency
}}
{{ARint|exit
|mile=129.53
|exit=
|espan=19
|road={{jct|state=AR|AR|18|name1=East Highland Drive}}
}}
{{ARint
|mile=131.74
|road={{jct|state=AR|AR|91|dir1=north|name1=East Johnson Avenue|to2=to|AR|141|location1=[[Jonesboro, Arkansas|Jonesboro Business District]]}}
|notes=Southern terminus of AR 91
}}
{{ARint
|mile=132.31
|road={{jct|state=AR|AR|351|dir1=north|name1=Old Greensboro Road}}
|notes=Southern end of AR 351 concurrency
}}
{{ARint
|mile=132.75
|road={{jct|state=AR|AR|351|extra=airport|location1=[[Jonesboro Municipal Airport|Airport]]}}
|notes=Northern end of AR 351 concurrency
}}
{{ARint
|location=none
|mile=136.7
|road={{jct|state=AR|US|49B|dab1=Brookland|dir1=north|location1=[[Brookland, Arkansas|Brookland Business District]]}}
|notes=
}}
{{ARint
|location=none
|mile=140.60
|road={{jct|state=AR|US|49B|dab1=Brookland|dir1=south|location1=[[Brookland, Arkansas|Brookland Business District]]}}
|notes=
}}
{{ARint
|county=Greene|cspan=9
|location=Paragould|lspan=8
|mile=144.65
|road={{jct|state=AR|AR|69|dir1=north}}
}}
{{ARint
|mile=146.85
|road={{jct|state=AR|US|412}}<!--signed how?-->
}}
{{ARint
|mile=147.34
|road={{jct|state=AR|AR|358|dir1=east}}
}}<!--no overlap signed-->
{{ARint
|mile=147.87
|road={{jct|state=AR|AR|358|dir1=west}}
}}
{{ARint
|mile=149.71
|road={{jct|state=AR|US|412B|US|49B|dab2=Paragould|dir2=north|city1=Walnut Ridge|location2=[[Cardwell, Missouri|Cardwell MO]]|location3=[[Paragould, Arkansas|Paragould Business District]]|extra=airport|location4=[[Kirk Field|Airport]]}}
}}
{{ARint
|mile=149.97
|road={{jct|state=AR|US|49Y|dab1=Paragould|to2=yes|US|412B|dir2=west|city1=Walnut Ridge}}
}}
{{ARint
|mile=151.13
|road={{jct|state=AR|AR|135|city1=Corning|location2=Business District}}
}}
{{ARint
|mile=151.88
|road={{jct|state=AR|US|49B|dab1=Paragould|dir1=south}}
}}
{{ARint
|location=Marmaduke
|mile=161.44
|road={{jct|state=AR|AR|34|location1=Business District}}
}}
{{ARint
|type=concur
|county=Clay
|cspan=4
|location=Rector
|lspan=2
|mile=168.86
|road={{jct|state=AR|AR|90|dir1=west|location1=[[Rector, Arkansas|Rector Business District]]}}
|notes=Southern end of AR 90 concurrency
}}
{{ARint
|mile=169.37
|road={{jct|state=AR|AR|119|dir1=south}}
}}
{{ARint
|location=Hargrave Corner
|mile=172.33
|road={{jct|state=AR|AR|90|dir1=east|location1=[[Kennett, Missouri|Kennett, MO]]}}
|notes=Northern end of AR 90 concurrency
}}
{{ARint
|type=concur
|location=Piggott
|mile=182.33
|road={{jct|state=AR|US|62|AR|1|dir2=north|ity1=Corning|city2=St. Francis|location3=[[Piggott, Arkansas|Piggott Business District]]}}
|notes=Northern terminus; northern end of AR 1 concurrency
}}
{{jctbtm|exit|col=8|keys=concur,incomplete,trans}}
==Related routes==
===U.S. Route 49E===
{{main|U.S. Route 49E}}
{{Infobox road small
|state=MS
|type=US
|route=49E
|length_mi=85.862
|length_ref=<ref name="MDOT">{{cite web|url=http://sp.mdot.ms.gov/Office%20of%20Highways/Planning/Programs/MDOT%20Public%20Roads%20Statistics%20Extent,%20Travel,%20and%20Designation.pdf|title=Mississippi Public Roads - Selected Statistics - Extent, Travel, and Designation|archive-date=February 20, 2014|archive-url=https://web.archive.org/web/20140220195558/http://sp.mdot.ms.gov/Office%20of%20Highways/Planning/Programs/MDOT%20Public%20Roads%20Statistics%20Extent,%20Travel,%20and%20Designation.pdf|url-status=dead |access-date=February 12, 2022}}</ref>
|location=[[Yazoo City, Mississippi|Yazoo City]]-[[Tutwiler, Mississippi|Tutwiler]]
|formed=
}}

'''U.S. Route 49E''' ('''US 49E''') is an {{convert|85.86|mi|km|adj=mid|-long}} [[United States Numbered Highways|U.S. Highway]] in the Delta region of [[Mississippi]]. It travels through [[Yazoo County, Mississippi|Yazoo]], [[Holmes County, Mississippi|Holmes]], [[Leflore County, Mississippi|Leflore]], and [[Tallahatchie County, Mississippi|Tallahatchie]] counties.
{{-}}
===U.S. Route 49W===
{{main|U.S. Route 49W}}
{{Infobox road small
|state=MS
|type=US
|route=49W
|location=[[Yazoo City, Mississippi|Yazoo City]]-[[Tutwiler, Mississippi|Tutwiler]]
|length_mi=81.894
|length_ref=<ref name="MDOT" />
|formed=
}}

'''U.S. Route 49W''' ('''US 49W''') is an {{convert|81.89|mi|km|adj=mid|-long}} [[United States Numbered Highways|U.S. Highway]] in the Delta Region of [[Mississippi]], passing through [[Yazoo County, Mississippi|Yazoo]], [[Humphreys County, Mississippi|Humphreys]], [[Sunflower County, Mississippi|Sunflower]], and [[Tallahatchie County, Mississippi|Tallahatchie]] counties.
{{-}}
===Mississippi Highway 149===
{{main|Mississippi Highway 149}}
{{Infobox road small
|state=MS
|type=MS
|route=149
|location=[[Stone County, Mississippi|Stone]], [[Covington County, Mississippi|Covington]], [[Simpson County, Mississippi|Simpson]], [[Rankin County, Mississippi|Rankin]], [[Yazoo County, Mississippi|Yazoo]], [[Humphreys County, Mississippi|Humphreys]], [[Sunflower County, Mississippi|Sunflower]], and [[Coahoma County, Mississippi|Coahoma]] counties
|length_mi=58.073
|length_ref=
|formed=2006
}}
'''Mississippi Highway 149''' ('''MS 149''') is a [[state highway]] in [[Mississippi]]. The route designation is given to six former segments of [[U.S. Route 49 in Mississippi|U.S. Route 49]] (US 49), and two former sections of [[U.S. Route 49W|US 49W]], within the state that have been bypassed. The sections run through [[Wiggins, Mississippi|Wiggins]], [[Mount Olive, Mississippi|Mount Olive]], between [[Magee, Mississippi|Magee]] and [[Sanatorium, Mississippi|Sanatorium]], between [[Mendenhall, Mississippi|Mendenhall]] and [[Braxton, Mississippi|Braxton]], in [[Richland, Mississippi]], between [[Yazoo City, Mississippi|Yazoo City]] and [[Silver City, Mississippi|Silver City]], [[Inverness, Mississippi|Inverness]], and [[Clarksdale, Mississippi|Clarksdale]]. The total length of the eight sections of MS 149 is {{convert|58.073|mi|km}}.
{{-}}
===Arkansas Highway 349===
{{main|Arkansas Highway 349}}
{{Infobox road small
|state=AR
|type=AR
|route=349
|location=[[Craighead County, Arkansas|Craighead]] and [[Lawrence County, Arkansas|Lawrence]] counties
|length_mi=6.89
|length_ref=
|formed=November 23, 1966
}}
'''Arkansas Highway 349''' is a designation for two [[List of Arkansas state highways|state highway]]s in [[Northeast Arkansas]]. One route of {{convert|4.45|mi|km}} begins at [[Arkansas Highway 226|Highway&nbsp;226]] and runs north to [[Arkansas Highway 18|Highway&nbsp;18]]/[[Arkansas Highway 91|Highway&nbsp;91]]. A second route of {{convert|2.44|mi|km}} begins at [[Arkansas Highway 230|Highway 230]] and runs north to [[Arkansas Highway 228|Highway&nbsp;228]]. Both routes are maintained by the [[Arkansas Department of Transportation]] (ArDOT).
{{-}}

===Special routes===
{{Main|Special routes of U.S. Route 49}}

==See also==
*{{portal-inline|Arkansas}}
*{{portal-inline|Mississippi}}
*{{portal-inline|U.S. Roads}}

==References==
{{Reflist}}

==External links==
{{Attached KML|display=title,inline}}
* [http://usends.com/49.html Endpoints of U.S. Highway 49]

{{US Highways}}

[[Category:U.S. Route 49| ]]
[[Category:United States Numbered Highway System|49]]
[[Category:U.S. Highways in Arkansas|49]]
[[Category:U.S. Highways in Mississippi|49]]
[[Category:Transportation in Harrison County, Mississippi]]
[[Category:Transportation in Stone County, Mississippi]]
[[Category:Transportation in Forrest County, Mississippi]]
[[Category:Transportation in Covington County, Mississippi]]
[[Category:Transportation in Simpson County, Mississippi]]
[[Category:Transportation in Rankin County, Mississippi]]
[[Category:Transportation in Madison County, Mississippi]]
[[Category:Transportation in Yazoo County, Mississippi]]
[[Category:Transportation in Tallahatchie County, Mississippi]]
[[Category:Transportation in Coahoma County, Mississippi]]
[[Category:Transportation in Phillips County, Arkansas]]
[[Category:Transportation in Monroe County, Arkansas]]
[[Category:Transportation in Woodruff County, Arkansas]]
[[Category:Transportation in Cross County, Arkansas]]
[[Category:Transportation in Poinsett County, Arkansas]]
[[Category:Transportation in Craighead County, Arkansas]]
[[Category:Transportation in Greene County, Arkansas]]
[[Category:Transportation in Clay County, Arkansas]]