https://wiki.sarg.dev/index.php?action=history&feed=atom&title=Coding_strandCoding strand - Revision history2026-04-20T15:43:31ZRevision history for this page on the wikiMediaWiki 1.44.2https://wiki.sarg.dev/index.php?title=Coding_strand&diff=313501&oldid=previmported>Apokrif: /* top */2024-06-08T08:36:32Z<p><span class="autocomment">top</span></p>
<p><b>New page</b></p><div>{{short description|DNA strand with the same base sequence as an mRNA transcript}}<br />
[[File:Process of DNA transcription.png|alt=Two linear DNA strands are separated by a blue oval, which is creating RNA by running along the template strand. The coding strand is above, not attached to RNA polymerase.|thumb|400x400px|Position of the template and coding strands during [[Transcription (biology)|transcription]].]]<br />
When referring to [[Transcription (genetics)|DNA transcription]], the '''coding strand''' (or '''informational strand'''<ref>{{Cite web|date=2015-08-26|title=28.4: Transcription of DNA|url=https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Map%3A_Organic_Chemistry_(McMurry)/28%3A_Biomolecules_-_Nucleic_Acids/28.04%3A_Transcription_of_DNA|access-date=2021-09-06|website=Chemistry LibreTexts|language=en}}</ref><ref>{{Cite book|last=STOKER|first=H. STEPHEN|title=General, Organic, and Biological Chemistry|publisher=Cengage Learning|year=2013|pages=816}}</ref>) is the [[DNA]] strand whose [[Nucleobase|base]] sequence is identical to the base sequence of the [[RNA]] transcript produced (although with [[thymine]] replaced by [[uracil]]). It is this strand which contains [[codons]], while the non-coding strand contains [[anticodon]]s. During transcription, [[RNA_polymerase_II|RNA Pol II]] binds to the non-coding '''template strand''', reads the anti-codons, and transcribes their sequence to synthesize an RNA transcript with complementary bases.<br />
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By convention, the coding strand is the strand used when displaying a DNA sequence. It is presented in the [[Directionality (molecular biology)|5' to 3' direction]].<br />
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Wherever a [[gene]] exists on a DNA [[molecule]], one strand is the coding strand (or '''sense strand'''), and the other is the '''noncoding strand''' (also called the [[sense (molecular biology)|antisense]] strand,<ref name="Lewin08">{{cite book|url=https://books.google.com/books?id=BrNpbPkzoxAC&pg=PA129|title=Genes IX|last=Lewin|first=Benjamin|publisher=Oxford University Press|year=2008|isbn=978-0-7637-4063-4|page=129, 235}}</ref> anticoding strand, '''template strand''' or''' transcribed strand''').<br />
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==Strands in transcription bubble==<br />
During [[Transcription (genetics)|transcription]], [[RNA polymerase]] unwinds a short section of the DNA [[double helix]] near the start of the gene (the transcription start site). This unwound section is known as the [[transcription bubble]]. The RNA polymerase, and with it the transcription bubble, travels along the noncoding strand in the opposite, 3' to 5', direction, as well as polymerizing a newly synthesized strand in 5' to 3' or [[Upstream and downstream (DNA)|downstream]] direction. The DNA double helix is rewound by RNA polymerase at the rear of the transcription bubble.<ref name=Lewin08/> Like how two adjacent zippers work, when pulled together, they unzip and rezip as they proceed in a particular direction. Various factors can cause double-stranded DNA to break; thus, reorder genes or cause cell death.<ref name="pmid28868264">{{cite journal |vauthors = Dianatpour A, Ghafouri-Fard S |title = The Role of Long Non Coding RNAs in the Repair of DNA Double Strand Breaks|journal = International Journal of Molecular and Cellular Medicine|volume = 6 |issue = 1 |pages = 1–12 |year = 2017 |pmid = 28868264 |pmc = 5568187}}</ref><br />
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==RNA-DNA hybrid==<br />
Where the helix is unwound, the coding strand consists of unpaired bases, while the template strand consists of an RNA:DNA composite, followed by a number of unpaired bases at the rear. This hybrid consists of the most recently added [[nucleotides]] of the RNA transcript, complementary base-paired to the template strand. The number of base-pairs in the hybrid is under investigation, but it has been suggested that the hybrid is formed from the last 10 nucleotides added.<ref>{{harvnb|Griffiths|2005|pp=259–265}}</ref> <br />
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== See also ==<br />
* [[Sense strand]]<br />
* [[Sense (molecular biology)]]<br />
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==References==<br />
{{reflist}}<br />
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==Works cited==<br />
*{{cite book |last1=Griffiths |first1=A.J.F. |title=Introduction to Genetic Analysis |publisher=W.H. Freeman |year=2005 |isbn=0-7167-4939-4 |edition=8th |display-authors=etal}}<br />
*{{cite book |author=Lewin, B. |title=Genes VII |url=https://archive.org/details/genesvii00lewi |url-access=registration |publisher=Oxford University Press |location=New York |year=2000 |isbn=0-19-879277-8 }}<br />
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[[Category:Molecular biology]]<br />
[[Category:DNA]]</div>imported>Apokrif