WME
WME may refer to:
- Windows Millennium Edition
- Windows Media Encoder
- Wireless Multimedia Extensions
- Wintermute Engine, a graphical adventure game engine by Dead:Code software
- William Morris Endeavor, a talent agency conglomerate
- Web-based Mathematics Education
- Working Memory Element in the Rete algorithm
- The IATA code for Mount Keith Airport in Western Australia
- Waze Map Editor
- National Rail station code for Woodmansterne railway station in London