1-Aminocyclopropane-1-carboxylic acid

1-Aminocyclopropane-1-carboxylic acid (ACC) is a disubstituted cyclic α-amino acid in which a cyclopropane ring is fused to the CTemplate:Sub atom of the amino acid. It is a white solid. Many cyclopropane-substituted amino acids are known, but this one occurs naturally.<ref>Template:Cite journal</ref>Template:Check Like glycine, but unlike most α-amino acids, ACC is not chiral.

Biochemistry

ACC is the precursor to the plant hormone ethylene.<ref name="Yang_1984">Template:Cite journal</ref><ref name="Kende_1993">Template:Cite journal</ref> It is synthesized by the enzyme ACC synthase (Template:EC number) from methionine and converted to ethylene by ACC oxidase (Template:EC number).<ref name="Kende_1989">Template:Cite journal</ref>

ACC also exhibits ethylene-independent signaling that plays a critical role in pollination and seed production by activating proteins similar to those involved in nervous system responses in humans and animals. More specifically, ACC signaling promotes secretion of the pollen tube chemoattractant LURE1.2 in ovular sporophytic tissue thus enhancing pollen tube attraction. Additionally, ACC activates Ca²⁺-containing ion currents via glutamate receptor-like (GLR) channels in root protoplasts.<ref>Template:Cite journal</ref>

ACC can be used by soil microorganisms (both bacteria and fungi) as a source of nitrogen and carbon.<ref name = "Liu_2019">Template:Cite journal</ref> As such, using ACC to incubate soils has been proven to induce the gene abundance encoding ACC-deaminases, which may have positive consequences on plant growth and stress tolerance.<ref name = "Liu_2019" /><ref>Template:Cite journal</ref>

ACC has also been extracted from kelp.<ref>Template:Cite journal</ref>

ACC is also an exogenous partial agonist of the mammalian NMDA receptor.<ref name="pmid15996549">Template:Cite journal</ref>

In 2019, the United States Environmental Protection Agency issued notice of an application for an experimental use permit to be issued for use of ACC as a pesticide.<ref>Template:Cite journal</ref>