3,3'-Diindolylmethane

3,3′-Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables, such as broccoli, Brussels sprouts, cabbage and kale.<ref name="lpi">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> It and its parent compound Template:Ndash indole-3-carbinol Template:Ndash are under laboratory research to determine their possible biological properties, particularly in anti-cancer mechanisms.<ref name=lpi/><ref name="pubchem">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> DIM is sold as a dietary supplement.<ref name=lpi/>

Properties

In vitro, DIM has action as a histone deacetylase inhibitor,<ref name=lpi/> specifically against HDAC1, HDAC2, and HDAC3.<ref name="dietaryncbi">Template:Cite journal</ref> DIM is a metabolite of indole-3-carbinol. <ref>Template:Cite news</ref>

DIM was found to be a mild cannabinoid agonist with low binding affinity for both CB1 and CB2.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref>

A study conducted in 2023 by researchers from Ben-Gurion University of the Negev, in collaboration with teams from Sichuan University and the National University of Singapore, found that DIM can reduce biofilms responsible for dental plaque and cavities by 90%.<ref>Template:Cite journal</ref> Template:Asof, no clinical trials have been conducted that confirm the effectiveness of DIM in reducing plaque.

See also

• Glucobrassicin, precursor to indole-3-carbinol
• Phytochemicals

External links

• Diindolylmethane Information Resource Center, University of California-Berkeley