Adrenochrome
Template:Short description Template:Cs1 config Template:About Template:Use dmy dates Template:Chembox
Adrenochrome is a chemical compound produced by the oxidation of adrenaline (epinephrine). It was the subject of limited research from the 1950s through to the 1970s as a potential cause of schizophrenia. While adrenochrome has no currently proven medical application, the semicarbazide derivative, carbazochrome, is a hemostatic medication. Adrenochrome is mass produced and commercially available to the public, and is not a controlled substance.<ref>Tamou Thahouly et al., Bovine Chromaffin Cells: Culture and Fluorescence Assay for Secretion, Methods Mol Biol 2021;2233:169-179. doi: 10.1007/978-1-0716-1044-2_11.</ref><ref>"Adrenochrome Supplies for Sale." Aobious: a New Experience, Aibous. Aobious Products Catalog, aobious.com/aobious/products/13456-adrenochrome.html. Accessed 30 June 2025. Archived at Internet Archive.</ref>
Despite this compound's name, it is unrelated to the element chromium; instead, the "chrome" suffix indicates a relationship to color, as pure adrenochrome has a deep violet color.<ref name=Aminochrome/>
Chemistry
The oxidation reaction that converts adrenaline into adrenochrome occurs both in vivo and in vitro. Silver oxide (Ag2O) was among the first reagents employed for this,<ref>Template:Cite journal</ref> but a variety of other oxidizing agents have been used successfully.<ref>Template:Cite journal</ref> In solution, adrenochrome is pink and further oxidation of the compound causes it to polymerize into brown or black melanin compounds.<ref name="HofferOsmond1967" />
Synthesis
Adrenochrome is readily synthesized from commercially available reagents: chloroacetic acid and catechol react in the presence of phosphoryl chloride to yield chloroacetylcatechol. After purification, chloroacetylcatechol is reacted with aqueous methylamine and treated with hydrochloric acid, yielding adrenalone hydrochloride. This is then hydrogenated to racemic adrenaline. Finally, adrenaline is oxidized to adrenochrome by an appropriate oxidizing agent such as silver oxide.<ref name="schayer">Template:Cite journal</ref>
History
Several small-scale studies involving 15 or fewer test subjects conducted in the 1950s and 1960s reported that adrenochrome triggered psychotic reactions such as thought disorder and derealization.<ref name=Smythies>Template:Cite journal</ref>
In 1954, researchers Abram Hoffer and Humphry Osmond claimed that adrenochrome is a neurotoxic, psychotomimetic substance and may play a role in schizophrenia and other mental illnesses.<ref name="pmid13152519">Template:Cite journal</ref> In what Hoffer called the "adrenochrome hypothesis",<ref name="Hoffer2">Template:Cite journal</ref> he and Osmond in 1967 speculated that megadoses of vitamin C and niacin could cure schizophrenia by reducing brain adrenochrome.<ref name="HofferOsmond1967">Template:Cite book</ref><ref name=hoffer94>Template:Cite journal</ref>
The treatment of schizophrenia with such potent anti-oxidants is controversial. In 1973, the American Psychiatric Association reported methodological flaws in Hoffer's work on niacin as a schizophrenia treatment and referred to follow-up studies that did not confirm any benefits of the treatment.<ref name="APA">Template:Cite web</ref> Multiple additional studies in the United States,<ref name="ArchGenPsy">Template:Cite journal</ref> Canada,<ref name="SZ Bull">Template:Cite journal</ref> and Australia<ref name="ANZJP">Template:Cite journal</ref> similarly failed to find benefits of megavitamin therapy to treat schizophrenia.
The adrenochrome theory of schizophrenia waned, despite some evidence that it may be psychotomimetic, as adrenochrome was not detectable in people with schizophrenia.Template:Citation needed
In the early 2000s, interest was renewed by the discovery that adrenochrome may be produced normally as an intermediate in the formation of neuromelanin.<ref name=Smythies /> This finding may be significant because adrenochrome is detoxified at least partially by glutathione-S-transferase. Some studies have found genetic defects in the gene for this enzyme.<ref>Template:Cite book</ref>
Adrenochrome is also believed to have cardiotoxic properties.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref>
In popular culture
- In his 1954 book The Doors of Perception, Aldous Huxley mentioned the discovery and the alleged effects of adrenochrome, which he likened to the symptoms of mescaline intoxication, although he had never consumed it.<ref name=adams />
- Anthony Burgess mentions adrenochrome as "drencrom" at the beginning of his 1962 novel A Clockwork Orange. The protagonist and his friends are drinking drug-laced milk: "They had no license for selling liquor, but there was no law yet against prodding some of the new veshches which they used to put into the old moloko, so you could peet it with vellocet or synthemesc or drencrom or one or two other veshches [...]"<ref name=adams />
- Hunter S. Thompson mentioned adrenochrome in his 1971 book Fear and Loathing in Las Vegas.<ref name="friedberg">Template:Cite magazine</ref> This is the likely origin of current myths surrounding this compound, because a character states that "There's only one source for this stuffTemplate:Nbsp... the adrenaline glands from a living human body. It's no good if you get it out of a corpse." The adrenochrome scene also appears in the novel's film adaptation.<ref name=adams>Template:Cite news</ref> In the DVD commentary, director Terry Gilliam admits that his and Thompson's portrayal is a fictional exaggeration. Gilliam insists that the drug is entirely fictional and seems unaware of the existence of a substance with the same name. Hunter S. Thompson also mentions adrenochrome in his book Fear and Loathing on the Campaign Trail '72. In the footnotes in chapter April, page 140, he says: "It was sometime after midnight in a ratty hotel room and my memory of the conversation is hazy, due to massive ingestion of booze, fatback, and forty cc's of adrenochrome."
- Adrenochrome is the subject of several conspiracy theories, including QAnon and Pizzagate,<ref>Template:Cite web</ref><ref>Template:Cite web</ref><ref>Template:Skeptoid</ref> in which the chemical plays a similar role to Satanic ritual abuse stories.<ref name="kantrowitz1">Template:Cite magazine</ref> The theories commonly state that a cabal of theistic Satanists rape and murder children, and harvest adrenochrome from their victims' blood as a recreational drug<ref>Template:Cite magazine</ref><ref>Template:Cite news</ref> or as an elixir of youth, similar to children's blood infusions.<ref>Children's blood infusions</ref><ref>Template:Cite news</ref> In reality, adrenochrome has been produced by organic synthesis since at least 1952,<ref name="schayer" /><ref>Template:Cite web</ref> is synthesized for research purposes by biotechnology companies, who will then sell it to anyone; as it is not a controlled substance, any medical or recreational use of the chemical is effortless to access.<ref>Template:Cite web</ref>
See also
References
External links
- Adrenochrome Commentary at erowid.org
- Adrenochrome deposits resulting from the use of epinephrine-containing eye drops used to treat glaucoma from the Iowa Eye Atlas (searched for diagnosis = adrenochrome)
- QAnon’s Adrenochrome Quackery, Joe Schwarcz, 10 Feb 2022, Office for Science and Society, McGill University