Avram Hershko

Avram Hershko (Template:Langx, Template:Langx;<ref>Template:Cite web</ref> born December 31, 1937) is a Hungarian-born Israeli biochemist who received the Nobel Prize in Chemistry in 2004.

Biography

He was born Herskó Ferenc in Karcag, Hungary, into a Jewish family,<ref>Template:Cite web</ref> the son of Shoshana/Margit 'Manci' (née Wulc) and Moshe Hershko, both teachers.<ref name="Nobel">Template:Nobelprize including the Nobel Lecture The Ubiquitin System for Protein Degradation and some of its Roles in the Control of the Cell Division Cycle</ref> During the Second World War, his father was forced into labor service in the Hungarian army and then taken as a prisoner by the Soviet Army. For years, Avram's family didn't known anything about what had happened to his father. Avram, his mother and older brother Chaim/Laszlo 'Laci' were put in a ghetto in Szolnok. During the final days of the ghetto, most Jews were sent to be murdered in Auschwitz, but Avram and his family managed to board trains that took them to a concentration camp in Austria, where they were forced into labor until the end of the war. Avram and his mother and brother survived the war and returned to their home. His father returned as well, 4 years after they had last seen him.<ref>Template:Cite web</ref>

Hershko and his family emigrated to Israel in 1950 and settled in Jerusalem. He received his MD in 1965 and his PhD in 1969 from the Hebrew University of Jerusalem-Hadassah Medical Center. He was a postdoctoral scholar at the University of California, San Francisco. He is currently a Distinguished Professor at the Rappaport Faculty of Medicine at the Technion in Haifa and a Distinguished Adjunct Professor at the New York University Grossman School of Medicine.

Along with Aaron Ciechanover and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. The ubiquitin-proteasome system has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as cancer, muscular and neurological diseases, and immune and inflammatory responses.

His contributions to science directly helped cure one of his long-time friends of cancer.<ref>Template:Cite web</ref>

Honours and awards

• 1987 – Weizmann Prize for SciencesTemplate:Citation needed
• 1994 – Israel Prize in Biochemistry<ref name=prize>Template:Cite web</ref>
• 1999 – Canada Gairdner International Award (with Alexander Varshavsky)
• 2000 – Albert Lasker Award for Basic Medical Research (with Aaron Ciechanover and Varshavsky)
• 2000 – Alfred P. Sloan Jr. Prize (with Varshavsky)
• 2000 – Member, Israel Academy of Sciences and Humanities
• 2001 – Louisa Gross Horwitz Prize from Columbia University (with Varshavsky)
• 2001 – Massry Prize from the Keck School of Medicine of USC, University of Southern California (with Varshavsky)
• 2001 – Wolf Prize in Medicine (with Varshavsky) for "the discovery of the ubiquitin system of intracellular protein degradation and the crucial functions of this system in cellular regulation."<ref>Template:Cite web</ref>
• 2002 – The EMET Prize for Art, Science and Culture in the category of Life Sciences (with Ciechanover and Leo Sachs)
• 2002 – E.B. Wilson Medal (with Varshavsky)
• 2003 – Foreign Associate, National Academy of Sciences, USA
• 2004 – Nobel Prize in Chemistry for his discovery with Ciechanover and Irwin Rose, of ubiquitin-mediated protein degradation<ref>Template:Cite web</ref>
• 2005 – Elected to the American Philosophical Society<ref>Template:Cite web</ref>

Publications

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Involvement with biotechnology

Hershko serves on the Scientific Advisory Board of Oramed Pharmaceuticals.<ref name="Oramed Pharmaceuticals 2020 b459">Template:Cite web</ref>

See also

• List of Israel Prize recipients
• List of Israeli Nobel laureates
• List of Jewish Nobel laureates
• Science and technology in Israel
• Raz Hershko (born 1998), Israeli European champion and Olympic judoka

External links

• Template:Nobelprize including the Nobel Lecture The Ubiquitin System for Protein Degradation and some of its Roles in the Control of the Cell Division Cycle
• Website at the Technion
• Avram Hershko's Short Talk: "Lessons from My Life in Science"
• "Hungarian" Nobel Prize winners Crooked Timber
• Avram Hershko Jewish Virtual Library
• Ubiquitin-Mediated Protein Degradation: From the lab to the bedside Dan Hersko
• The Official Site of Louisa Gross Horwitz Prize