Cyclopia

Template:Short description Template:Use dmy dates Template:About Template:Infobox medical condition (new) Cyclopia (named after the Greek mythology characters cyclopes), also known as alobar holoprosencephaly, is the most extreme form of holoprosencephaly and is a congenital disorder (birth defect) characterized by the failure of the embryonic prosencephalon to properly divide the orbits of the eye into two cavities. Its incidence is 1 in 16,000 in born animals and 1 in 200 in miscarried fetuses.<ref>Taber's Cyclopedic Medical Dictionary, Template:ISBN</ref><ref>Leroi, Armand Marie Mutants: On Genetic Variety and the Human Body, p.73. Template:ISBN</ref>

Signs and symptoms

Typically, the nose is either missing or not functional. This deformity (called proboscis) forms above the center eye and is characteristic of a form of cyclopia called rhinencephaly or rhinocephaly.<ref>Dark, Graham (2007). Rhinocephaly. In Online Medical Dictionary. Retrieved July 23, 2008.</ref> Most such embryos are either naturally miscarried or are stillborn upon delivery.

Although cyclopia is rare, several cyclopic human babies are preserved in medical museums (e.g. The Vrolik Museum, Amsterdam, Trivandrum Medical College).<ref>Template:Cite web</ref>

Some extreme cases of cyclopia have been documented in farm animals (horses, sheep, pigs, goats, and sometimes chickens). In such cases, the nose and mouth fail to form, or the nose grows from the roof of the mouth, obstructing airflow and resulting in suffocation shortly after birth.<ref name="freakyface">Template:Cite web</ref>

Causes

Genetic defects or toxins can misdirect the embryonic forebrain-dividing process.<ref name="medterms">Template:Cite web</ref> One highly teratogenic alkaloid toxin that can cause cyclopia is cyclopamine or 2-deoxyjervine, found in the plant Veratrum californicum (also known as corn lily or false hellebore). Grazing animals are most likely to ingest this plant and induce cyclopia in offspring. People sometimes accidentally ingest false hellebore while pregnant thinking it is hellebore, which has been suggested as a "natural" treatment for vomiting, cramps, and poor circulation – three conditions which may be present in the early stages of pregnancy.<ref>Template:Cite web</ref> Cyclopia occurs when certain proteins are inappropriately expressed,<ref>Template:Cite journal</ref> causing the brain to stay whole, rather than developing two distinct hemispheres. This leads to the fetus having one optic lobe and one olfactory lobe, resulting in the eye and nose malformations of cyclopia.<ref>Template:Cite journal</ref>

The Sonic hedgehog protein (SHH) is the gene regulator involved in the separation of the single eye field into two bilateral fields.<ref>Template:Cite book</ref> Although not proven, it is thought that SHH emitted from the prechordal plate suppresses Pax6, which causes the eye field to divide into two. If the SHH gene is mutated, the result is cyclopia, a single eye in the center of the face (Gilbert, 2000).

Notable cases

A British description from 1665 of a colt that appeared to have cyclopia reads:Template:Blockquote
In October 1766, an infant in France was born with cyclopia, living for only a few hours. Reports of the case were made in the Mercure de France and an illustration of the infant was made by Marie Bihéron. The case was also mentioned in Volume IV of Buffon's L'Histoire Naturelle.

A Swedish description from 1793 of a newborn with cyclopia

On 1 March 1793, a 46-year-old woman in Boalts Torp, Glimåkra, Sweden gave birth to a child with cyclopia that died after two hours. The child was 35 cm long, its face without nose and nostrils, and its lidless eye with no eyebrow sat raised on the middle of its forehead like a large blueberry. The wrists were somewhat crooked as well as the right foot which was completely crooked and bent inwards. It was not clear whether it was a boy or a girl, but it was believed to be the former.<ref>Template:Cite book</ref>
In November 1889, reports emerged from Umatilla County, Oregon, of a Nez Perce child with one eye in the center of the forehead. The child was reportedly healthy and "able to see with ease, and ran about with as much freedom as any of his companions."<ref>Template:Cite news</ref><ref>Template:Cite news</ref><ref>Template:Cite news</ref> Several individuals tried to locate the child to be put on display, but the tribe had left to hunt in the mountains by the time they arrived.<ref>Template:Cite news</ref> It is unknown what became of the child.
On December 28, 2005, a kitten with cyclopia, "Cy", was born in Redmond, Oregon, United States and died about one day after birth.<ref name=cy>Template:Cite web</ref>
In 2006, a baby girl in India with cyclopia was born. Her only eye was in the center of her forehead. She did not have a nose and her brain did not separate into two separate hemispheres (holoprosencephaly).<ref name="Cyclops Baby">Template:Cite web</ref> The child died one day after her birth.<ref name="Cyclops Baby Born in India Only Survives 1 Day">Template:Cite web</ref>
In 2011, an albino cyclops shark fetus was discovered in the body of a caught shark in Mexico, with no discernible nose and one giant eye. The unborn fetus was turned over for medical studies.<ref>Template:Cite web</ref>
On October 10, 2012, a small kitten was born. Its eye was in the center of the forehead and there was no developed nose to be found. The small cat died shortly after it was born. It was nicknamed Cleyed the Cyclops.<ref name=cleyed>Template:Cite web</ref>
On May 10, 2017, in Assam, India, a black goat was born with one eye and other cyclopia-related facial abnormalities. It was reported to still be alive over a week later, which is unusual for this condition.<ref>Template:Cite web</ref>
On September 13, 2018, in Mandailing Natal, North Sumatra, Indonesia, a baby with cyclopia was born without a nose and one eye with the weight of 2.4kg (5.3lb) and heart rate under 100 bpm. The child died seven hours after birth.<ref>Template:Cite web</ref>
On March 16, 2022, a boy was born in Al Bayda, Yemen, with cyclopia. He died 7 hours after birth. He was seen in photos taken by Yemeni journalist Karim Zarai.<ref>Template:Cite web</ref>
In March 2024, a pig was born in Ilocos Sur, Philippines, with cyclopia.<ref>Template:Cite web</ref>
In December 2024, the Korean Society of Perinatology documented a female infant with cyclopia who survived for 8 months on palliative care, which is the longest known to date. The baby girl was born as part of a twin birth, with the other twin being reportedly normal. <ref>Template:Cite journal</ref>

Cultural significance

The Islamic State used photos of babies born with cyclopia in its recruitment campaign. ISIS claimed the photos depicted Masih ad-Dajjal, who according to the Hadith, would have only one eye. Mainstream Islamic scholars consider the prophecy as referring to a one-eyed man, not a cyclops.<ref name="isil">Template:Cite web</ref> One infant whose image was circulated in 2014 was claimed to be Israeli, but was actually Bolivian and from 2008. The baby girl from India born in 2006 (see notable cases above) also had her image used.<ref>Template:Cite web</ref>