Deoxycytidine
Template:Use dmy dates Template:Cs1 config Template:Chembox Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. It is similar to the ribonucleoside cytidine, but with one hydroxyl group removed from the C2' position. Deoxycytidine can be phosphorylated at C5' of the deoxyribose by deoxycytidine kinase, converting it to deoxycytidine monophosphate (dCMP), a DNA precursor.<ref>Template:Cite book</ref> dCMP can be converted to dUMP and dTMP.Template:Fact
Doxecitine is the international nonproprietary name.<ref>Template:Cite journal</ref>
Clinical significance
Deoxycytidine can be used as a precursor for 5-aza-2′-deoxycytidine, a treatment for people with myelodysplastic syndrome. This compound slows the cell cycle by interfering with the methylation of the P15/INK4B gene, increasing the expression of P15/INK4B protein which subdues the transformation of MDS to leukemia.<ref>Template:Cite book</ref>
Deoxycytidine can serve as a biomarker for tumor diagnosis. Deoxycytidine can be used as a biomarker for breast cancer patients and healthy individuals. 5-(Hydroxymethyl)-2′-deoxycytidine (5-hmdC), 5-(formyl)-2′-deoxycytidine (5-fodC), and 5-(carboxyl)-2′-deoxycytidine (5-cadC) are intermediates in the DNA demethylation pathway and can act as biomarkers. 5-hmdC levels were significantly reduced in urine samples of breast cancer patients, while 5-fodC and 5-cadC levels were elevated.<ref>Template:Cite journal</ref>
Doxecitine is a component of the medication doxecitine/doxribtimine used for the treatment of thymidine kinase 2 deficiency.<ref name="FDA 20251103">Template:Cite web Template:PD-notice</ref>
References
External links
Template:Nucleobases, nucleosides, and nucleotides Template:Portal bar Template:Authority control