M104

M104 or M-104 may refer to:

• Sombrero Galaxy, called M104 by Messier number
• M104 group of galaxies
• HMS Walney (M104), a British warship
• M104 Wolverine, a military armored bridge
• M104 155mm Cartridge, a U.S. Army chemical artillery shell
• M104 (New York City bus), a New York City Bus route in Manhattan
• Mercedes-Benz M104 engine
• M-104 highway (Michigan), a road in the United States
• a Y-chromosome mutation, also called P22