N-Ethyltryptamine
N-Ethyltryptamine (NET), also abbreviated as NETP, is a tryptamine that is structurally related to N-methyltryptamine (NMT) and the psychedelic drugs N,N-dimethyltryptamine (DMT) and N,N-diethyltryptamine (DET).<ref name="TiHKAL">NET Entry in TIHKAL</ref>
Use and effects
Alexander Shulgin included NET as an entry in his book TiHKAL (Tryptamines I Have Known and Loved).<ref name="TiHKAL" /> However, he stated that it had been subjected only to modest human trials and that no active dose level had been identified.<ref name="TiHKAL" />
Pharmacology
Pharmacodynamics
| Target | Affinity (Ki, nM) |
|---|---|
| 5-HT1A | Template:Abbr |
| 5-HT2A | 38 (Template:Abbrlink) 99% (Template:Abbrlink) |
| SERT | 19a (Template:Abbr) |
| Template:Abbrlink | 3,862a (Template:Abbr) |
| Template:Abbrlink | 6,660a (Template:Abbr) |
| Notes: The smaller the value, the more avidly the drug interacts with the site. Footnotes: a = Neurotransmitter release. Sources: <ref name="BloughLandavazoDecker2014" /> | |
NET has been found to act as a potent serotonin 5-HT2A receptor full agonist and a selective serotonin releasing agent.<ref name="BloughLandavazoDecker2014">Template:Cite journal</ref> It is inactive at the 5-HT1A receptor.<ref name="BloughLandavazoDecker2014" />
Chemistry
Synthesis
The chemical synthesis of NET has been described.<ref name="TiHKAL" />
Analogues
Analogues of NET include N-methyltryptamine (NMT), dimethyltryptamine (DMT), methylethyltryptamine (MET), and diethyltryptamine (DET), among others.<ref name="TiHKAL" />
See also
References
External links
Template:Serotonin receptor modulators Template:Monoamine releasing agents {{#invoke:Navbox|navbox}}