Timeline of human vaccines

Template:Short description Template:Use dmy dates This is a timeline of the development of prophylactic human vaccines. Early vaccines may be listed by the first year of development or testing, but later entries usually show the year the vaccine finished trials and became available on the market. Although vaccines exist for the diseases listed below, only smallpox has been eliminated worldwide. The other vaccine-preventable illnesses continue to cause millions of deaths each year.<ref>Template:Cite journal</ref> CurrentlyTemplate:When, polio and measles are the targets of active worldwide eradication campaigns. Template:TOCright

18th century

• 1796 – Edward Jenner develops and documents first vaccine for smallpox.<ref name=HoVSmallpox>Template:Cite web</ref>

19th century

• 1881 - First vaccine for anthrax by Louis Pasteur<ref>Template:Cite book</ref>
• 1884-1885 – First vaccine for cholera by Jaime Ferran y Clua<ref>Template:Cite journal</ref><ref name=HoVCholera>Template:Cite web</ref>
• 1885 – First vaccine for rabies by Louis Pasteur and Émile Roux<ref>Template:Cite web</ref><ref name=HoVRabies>Template:Cite web</ref>
• 1890 – First vaccine for tetanus (serum antitoxin) by Emil von Behring<ref name=HoVTetanus>Template:Cite web</ref>
• 1896 – First vaccine for typhoid fever by Almroth Edward Wright, Richard Pfeiffer, and Wilhelm Kolle<ref name=HoVTyphoid>Template:Cite web</ref>
• 1897 – First vaccine for bubonic plague by Waldemar Haffkine

20th century

• 1921 – First vaccine for tuberculosis by Albert Calmette<ref name=Calmette1922>Template:Cite book</ref><ref name=HoVTB>Template:Cite web</ref>
• 1923 – First vaccine for diphtheria by Gaston Ramon, Emil von Behring and Kitasato Shibasaburō
• 1924 – First vaccine for scarlet fever by George F. Dick and Gladys Dick
• 1924 – First inactive vaccine for tetanus (tetanus toxoid, TT) by Gaston Ramon, C. Zoeller and P. Descombey
• 1926 – First vaccine for pertussis (whooping cough) by Leila Denmark
• 1932 – First vaccine for yellow fever by Max Theiler and Jean Laigret
• 1937 – First vaccine for typhus by Rudolf Weigl, Ludwik Fleck and Hans Zinsser
• 1937 – First vaccine for influenza by Anatol Smorodintsev<ref>Plotkin, S.L. and Plotkin, S.A. "A short history of vaccination." In: Vaccines, Stanley A. Plotkin, Walter A. Orenstein, Paul A. Offit, eds. Elsevier Health Sciences, 2008, pp. 8.</ref>
• 1941 – First vaccine for tick-borne encephalitis
• 1952 – First vaccine for polio by a Jonas Salk
• 1954 – First vaccine for Japanese encephalitis
• 1957 – First vaccine for adenovirus-4 and 7
• 1962 – First oral vaccine for polio by Albert Sabin
• 1963 – First vaccine for measles by John Franklin Enders
• 1967 – First vaccine for mumps
• 1970 – First vaccine for rubella
• 1977 – First vaccine for pneumonia (Streptococcus pneumoniae)
• 1978 – First vaccine for meningitis (Neisseria meningitidis)
• 1980 – Smallpox declared eradicated worldwide due to vaccination efforts
• 1981 – First vaccine for hepatitis B (first vaccine to target a cause of cancer)
• 1984 – First vaccine for chicken pox
• 1985 – First vaccine for Haemophilus influenzae type b (HiB)
• 1989 – First vaccine for Q fever<ref>Template:Cite web</ref>
• 1990 – First vaccine for hantavirus hemorrhagic fever with renal syndrome
• 1991 – First vaccine for hepatitis A<ref>Template:Cite book</ref>
• 1998 – First vaccine for Lyme disease
• 1998 – First vaccine for rotavirus<ref>Template:Cite journal</ref>

21st century

• 2000 – First pneumococcal conjugate vaccine approved in the U.S. (PCV7 or Prevnar)<ref>Template:Cite web</ref>
• 2003 – First nasal influenza vaccine approved in U.S. (FluMist)
• 2003 – First vaccine for Argentine hemorrhagic fever.<ref>Template:Cite journal</ref>
• 2006 – First vaccine for human papillomavirus (which is a cause of cervical cancer)
• 2006 – First herpes zoster vaccine for shingles
• 2011 – First vaccine for non-small-cell lung carcinoma (comprises 85% of lung cancer cases)
• 2012 – First vaccine for hepatitis E<ref>Template:Cite journal</ref>
• 2012 – First quadrivalent (4-strain) influenza vaccine
• 2013 – First vaccine for enterovirus 71, one cause of hand, foot, and mouth disease<ref>Template:Cite journal</ref>
• 2015 – First vaccine for malaria<ref>Template:Cite journal</ref>
• 2015 – First vaccine for dengue fever<ref>Template:Cite web</ref>
• 2019 – First vaccine for Ebola approved<ref>Template:Cite press release</ref>
• 2020 – First vaccine for COVID-19
• 2023 – First respiratory syncytial virus vaccine
• 2023 – First vaccine for Chikungunya