Tolnaftate
Template:Short description Template:Drugbox Tolnaftate (INN),<ref name="INN" /> sold under the brand name TAGRID, among others, is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, liquid, and liquid aerosol.<ref name=":1" /> Tolnaftate is used to treat fungal conditions such as jock itch, athlete's foot and ringworm.<ref name=":1">Template:Cite web</ref> Tolnaftate was discovered by Teruhisa Noguchi in 1962 while he was working for the Nippon Soda Company.<ref>Template:Cite journal</ref>
Mechanism
Although the exact mechanism of action is not entirely known, it is believed to inhibit squalene epoxidase,<ref name="pmid3524433">Template:Cite journal</ref> an important enzyme in the biosynthetic pathway of ergosterol (a key component of the fungal cell membrane) in a similar way to terbinafine.<ref name="urlantifung">Template:Cite web</ref>
Uses
Tolnaftate has been found to be generally slightly less effective than azoles when used to treat tinea pedis (athlete's foot). It is, however, useful when dealing with ringworm, especially when passed from pets to humans.<ref>Crawford F, Hart R, Bell-Syer S, Torgerson D, Young P, Russell I. Topical treatments for fungal infections of the skin and nails of the foot (Cochrane Review). In: The Cochrane Library, Issue 1, 2003. Oxford: Update Software.</ref>
Side effects
Side effects that may occur include:<ref name=":0">Template:Cite web</ref>
- allergic reactions like:
- inflammation, redness, or pain at the affected area
Less severe side effects include:<ref name=":0" />
- dry skin
- mild skin irritation, burning, or itching at the affected area
See also
- Liranaftate, a similar thiocarbamate antifungal
References
External links
Template:Antifungals Template:Xenobiotic-sensing receptor modulators